工作经历

代表论文

Xu C#, Li C#, Chen J#, Xiong Y#, Qiao Z, Fan P, Li C, Ma S, Liu J, Song A, Tao B, Xu T, Xu W, Chi Y, Xue J, Wang P, Ye D, Gu H, Zhang P, Wang Q, Xiao R, Cheng J, Zheng H, Yu X, Zhang Z, Wu J, Liang K, Liu YJ, Lu H*, Chen FX*. R-loop dependent promoter-proximal termination maintains genome stability. Nature. (Accept in principle). (*: corresponding)

Hu S#, Song A#, Peng L#, Tang N, Qiao Z, Wang Z, Lan F, Chen FX*. H3K4me2/3 modulate the stability of RNA polymerase II pausing. Cell Research. 2023 May;33(5):403-406. (*: corresponding)

Hu S#, Peng L#, Song A#, Ji YX#, Cheng J, Wang M, Chen FX*. INTAC endonuclease and phosphatase modules differentially regulate transcription by RNA polymerase II. Molecular Cell. 2023 Apr 11:S1097-2765(23)00212-5. (*: corresponding)

Wang Z#, Song A#, Xu H#, Hu S, Tao B, Peng L, Wang J, Li J, Yu J, Wang L, Li Z, Chen X, Wang M, Chi Y, Wu J, Xu Y, Zheng H, Chen FX*. Coordinated regulation of RNA polymerase II pausing and elongation progression by PAF1. Science Advances. 2022 Apr;8(13):eabm5504. (*: corresponding)

Wang X, Qi Y, Wang Z, Wang L, Song A, Tao B, Li J, Zhao D, Zhang H, Jin Q, Jiang YZ, Chen FX*, Xu Y*, Chen X*. RPAP2 regulates a transcription initiation checkpoint by inhibiting assembly of pre-initiation complex. Cell Reports. 2022 Apr 26;39(4):110732.  (*: corresponding)

Hu S#, Peng L#, Xu C#, Wang Z, Song A, and Chen FX*. SPT5 stabilizes RNA polymerase II, orchestrates transcription cycles, and maintains the enhancer landscape. Molecular Cell. 2021 Nov 4;81(21):4425-4439.e6. (*: corresponding)

Zheng H#, Qi Y#, Hu S#, Cao X#, Xu C#, Yin Z, Chen X, Li Y, Liu W, Li J, Wang J, Wei G, Liang K, Chen FX*, Xu Y*. (2020) Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase. Science. 2020 Nov 27;370(6520):eabb5872. (*: corresponding)

Chen FX, Smith ER, Shilatifard A. Born to run: Control of RNA polymerase II transcription elongation. Nature Reviews Molecular Cell Biology. 2018 May 8. doi:10.1038/s41580-018-0010-5.

Chen FX, Xie P, Collings CK, Cao K, Marshall SA, Rendleman EJ, Ugarenko M, Zhang A, Shiekhattar R, Smith ER, Shiekhattar R, Zhang MQ, Shilatifard A. PAF1 regulation of promoter-proximal pause release via enhancer activation. Science. 2017 Sep 22;357(6357):1294-1298.

Chen FX, Woodfin AR, Gardini A, Rickels RA, Marshall SA, Smith ER, Shiekhattar R, Shilatifard A. PAF1, a molecular regulator of promoter-proximal pausing by RNA polymerase II. Cell. 2015 Aug;162(5):1003-1015.

Chen F, Gao X, Shilatifard A. Stably paused genes revealed through inhibition of transcription initiation by the TFIIH inhibitor triptolide. Genes & Development. 2015 Jan 1;29(1):39-47.

Chen F*, Yang H*, Dong Z*, Fang J, Wang P, Zhu T, Gong W, Fang R, Shi YG, Li Z#, Xu Y#. Structural insight into substrate recognition by histone demethylase LSD2/KDM1b. Cell Research. 2013 Feb;23(2):306.

Fang R*, Chen F*, Dong Z, Hu D, Barbera AJ, Clark EA, Fang J, Yang Y, Mei P, Rutenberg M, Li Z, Zhang Y, Xu Y, Yang H, Wang P, Simon MD, Zhou Q, Li J, Marynick MP, Li X, Lu H, Kaiser UB, Kingston RE, Xu Y#, Shi YG#. LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation. Molecular Cell. 2013 Feb 7;49(3):558-70.

Chen FX, Marshall SA, Deng Y, Tianjiao S. Measuring Nascent Transcripts by Nascent-seq. Methods in Molecular Biology. 2018;1712:19-26.

Huang YH, Hu J, Chen F, Lecomte N, Basnet H, David CJ, Witkin MD, Allen PJ, Leach SD, Hollmann TJ, Iacobuzio-Donahue CA, Massague J. ID1 mediates escape from TGF-β tumor suppression in pancreatic cancer.Cancer Discovery. 2019 Oct 3. pii: CD-19-0529.