双聘课题组长
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  • 舒易来

    博士,研究员,博士生导师

    地址:上海市医学院路138号生物医学研究院,上海200032

    电话:(021)64377134

    邮箱:yilai_shu@fudan.edu.cn

工作经历
研究员,复旦大学附属眼耳鼻喉科医院(2018.12-至今)
副主任医师,复旦大学附属眼耳鼻喉科医院(2017.11-至今)
主治医师,复旦大学附属眼耳鼻喉科医院(2014.08-2017.11)
博士后,哈佛大学医学院(2012.07-2014.07)
教育经历
联合培养博士 哈佛大学医学院 麻省眼耳鼻喉科医院(2010.10-2012.06)
硕博连读 复旦大学 附属眼耳鼻喉科医院(2007.09-2012.06)
学士 南华大学 临床医学系(1999.09-2004.06)
所获人才项目
国家优秀青年科学基金(2018)
上海市浦江人才A类 (2015)
复旦大学“卓越2025”卓识人才(2019)
所获奖项
上海市银蛇奖二等奖(2019)
复旦大学附属眼耳鼻喉科医院“汾阳杰青奖” (2018)
美国耳鼻咽喉头颈外科研究年会优秀医师(2015、2017)
研究方向
据WHO估计,超过全世界人口的5%,也就是4.66亿人,患有残疾性听力损失(4.32亿成人和3400万儿童),课题组的工作围绕如下开展:1)基于CRISPR/Cas9基因编辑的遗传性耳聋基因治疗;2)内耳毛细胞再生和听觉保护。发表SCI文章36篇,其中第一/通讯作者27篇,建立和发现了遗传性耳聋基因治疗内耳导入新路径和新载体,得到广泛应用;首次以 CRISPR/Cas9 蛋白系统对活体内耳感觉细胞进行基因编辑;发现成年哺乳动物内耳支持细胞和毛细胞增殖转分化再生;发现自噬在耳毒性药物耳聋听觉保护过程中起到重要调控作用。主持包括国自然优青、面上、青年、上海市科委政府间合作(芬兰)、上海浦江人才、市科委自然科学探索类、复旦大学“卓越2025”卓识人才项目等9项纵向课题。
代表论文

1.Yilai Shu#, Wenyan Li#, Mingqian Huang#, Yi-Zhou Quan#, Yong Tao, Xuezhong Liu, Konrad Hochedlinger, Zhengmin Wang, Huawei Li and Zheng-Yi Chen*Renewed proliferation in adult mouse cochlea and regeneration of hair cells, Nature communication. 2019 Dec 4;10(1):5530. doi: 10.1038/s41467-019-13157-7.

2.Yilai Shu#, Lijun Wang#, Xiaoting Cheng, Chayada Tangshewinsirikul, Weili Shi, Yasheng Yuan, Zhiqiang Yang, Huawei Li, Jun Shen*, Bing Chen*, Weiguo Zou* The p.Pro170Leu Variant in NOG Impairs Noggin Secretion and Causes Autosomal Dominant Congenital Conductive Hearing Loss Due to Stapes Ankylosis, Journal of Genetics and Genomics, 2019 Sep 20;46(9):445-449.

3. Jinghan Wang#, Jun Shen#, Luo Guo, Cheng Cheng, Renjie Chai, Yilai Shu* Huawei Li*. A humanized mouse model demonstrated that apparently autosomal dominant deafness caused by MYO6 p.C442Y is inherited in a semi-dominant pattern. Hearing research, 2019 Aug;379:79-88. doi: 10.1016/j.heares.2019.04.014. Epub 2019 Apr 26.

4.Zuris JA, Thompson DB, Shu Y, Guilinger JP, Bessen JL, Hu JH, Maeder ML, Joung JK, Chen ZY, Liu DR*. Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo. Nature Biotechnology. 2015 Jan;33(1):73-80.

5.Xi Gu#, Renjie Chai, Luo Guo, Biao Dong, Wenyan Li, Yilai Shu*,Xinsheng Huang1* Huawei Li*.Transduction of Adeno-Associated Virus Vectors Targeting Hair Cells and Supporting Cells in the Neonatal Mouse Cochlea. Frontiers in Cellular Neuroscience. 2019. doi: 10.3389/fncel.2019.00008. 

6.Xiaoting Cheng#, Yanqing Fang, Yilai Shu*, Duo-Duo Tao, Yangwenyi Liu, Bing Wang, Yasheng Yuan, John J. Galvin, Qian-Jie Fu, Bing Chen* Music training can improve music and speech perception in pediatric Mandarin-speaking cochlear implant users. Trends in Hearing2018 9:2331216518759214, doi: 10.1177/2331216518759214.

7.Yilin Shen, Bin Ye, Penghui Chen, Quan Wang, Cui Fan, Yilai Shu*, Mingliang Xiang*. Cognitive Decline, Dementia, Alzheimer’s disease and Presbycusis: Examination of the Possible Molecular Mechanism, Frontiers in Neuroscience, 2018 Jun 8;12:394. doi: 10.3389/fnins.2018.00394.

8.Gao X, Tao Y, Lamas V, Huang M, Yeh WH, Pan B, Hu YJ, Hu JH, Thompson DB, Shu Y, Li Y, Wang H, Yang S, Xu Q, Polley DB, Liberman MC, Kong WJ, Holt JR, Chen ZY*, Liu DR*. Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents. Nature. 2018 Jan 11;553(7687):217-221.

9.He Z#, Guo L#, Shu Y#, Fang Q, Zhou H, Liu Y, Liu D, Lu L, Zhang X, Ding X, Liu D, Tang M, Kong W, Sha S, Li H, Gao X, Chai R. Autophagy protects auditory hair cells against neomycin-induced damage. Autophagy. 2017 Oct 2:1-21. 13(11):1884-1904. 

10. Shu Y#, Tao Y, Wang Z, Tang Y, Li H, Dai P, Gao G, Chen ZY*. Identification of Adeno-associated viral vectors (AAV) that target neonatal and adult mammalian inner ear cell subtypes. Human Gene Therapy. 27(9):687-99.2016 Jun 24.(Cover story

11.Shu Y#, Tao Y, Li W, Shen J, Wang Z, Chen ZY. Adenovirus Vectors Target Several Cell Subtypes of Mammalian Inner Ear In Vivo. Neural Plast. 2016;2016:9409846. doi: 10.1155/2016/9409846

12.Li M, Tao Y, Shu Y, LaRochelle JR, Steinauer A, Thompson D, Schepartz A, Chen ZY, Liu DR*. Discovery and characterization of a peptide that enhances endosomal escape of delivered proteins in vitro and in vivo. J Am Chem Soc. 2015 Nov 11;137(44).


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