全聘课题组长
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  • 顾宏周

    博士,研究员,博士生导师
    地址: 东安路130号,西13楼421室,上海 200032
    电话: 021-54237322
    邮件: hongzhou.gu@fudan.edu.cn

工作经历
2015.6~今:复旦大学生物医学研究院,研究员
2009.11~2015.5:耶鲁大学分子生物系,博士后
教育经历
2004.8~2009.9:纽约大学,化学系,博士
1999.9~2004.7:中国科学技术大学,应用化学系,学士
研究方向
课题组致力于DNA纳米技术和核酸类分子探针的研究。我们过去以合成DNA为单元构建并组装精密可控的“纳米装配线”,将宏观法则移植应用于微观,提升纳米制备的手段;围绕适配体构建变构型分子传感器,实现了对目标分子的快速精确检测,并证明了其在高通量筛选新型抗生素药物方面的潜力;开发高效的试管内进化策略,筛选并发现具极强水解活性的DNA序列,揭示了DNA鲜为人知的一面。我们目前一方面在探索DNA纳米结构设计的新方法,另一方面在组装筛选可检测重大疾病信号分子的核酸探针,希望通过这些研究为DNA纳米生物工程学与转化医学间搭起一座桥梁。
代表论文
  1. Yang, Y., Wu, Z., Wang, L., Zhou, K., Xia, K., Xiong, Q., Liu, L., Zhang, Z., Chapman, E. R., Xiong, Y., Melia, T. J., Karatekin, E., Gu, H.*, and Lin, C.* (2021) Sorting sub-150-nm liposomes of distinct sizes by DNA-brick-assisted centrifugation. Nature Chemistry    https://www.nature.com/articles/s41557-021-00667-5 (*为通讯作者

  2. Jia Y, Chen L, Liu J, Li W, Gu H.* (2021) DNA-catalyzed efficient production of single-stranded DNA nanostructures. Chem https://www.cell.com/chem/fulltext/S2451-9294(20)30633-1*为通讯作者

  3. Zhang, C., Li, Q., Xu, T., Li, W., He, Y., and Gu H.* (2021) New DNA-hydrolyzing DNAs isolated from an ssDNA library carrying a terminal hybridization stem. Nucleic Acids Research *为通讯作者

  4. Du, X., Cheng, X., Li, W., Ge, Z., Zhong, C., Fan, C., and Gu, H.* (2021) Engineering Allosteric Ribozymes to Detect Thiamine Pyrophosphate in Whole Blood. Analytical Chemistry  https://pubs.acs.org/doi/10.1021/acs.analchem.0c05276(*为通讯作者)

  5. Li, H.-Y., Yin, F.-F., Li, X.-Y., Jia, W.-N., Ding, J., Zhang, L., Wang, Z.-H., Hu, Q.-Q., Zuo, J.-L., Jia, H.-L., Wang, L.-H., Fan, C.-H.*, Gu, H.*, and Wu, J.* (2021) Novel aptasensor-based assay of sonic hedgehog ligand for detection of portal vein invasion of hepatocellular carcinoma. Biosensors & Bioelectronics 174 https://doi.org/10.1016/j.bios.2020.112738*为通讯作者)

  6. Tang, D.-J., Du, X., Shi, Q., Zhang, J.-L., He, Y.-P., Chen, Y.-M., Ming, Z., Wang, D., Zhong, W.-Y., Liang, Y.-W., Liu, J.-Y., Huang, J.-M., Zhong, Y.-S., An, S.-Q., Gu, H.*, and Tang, J.-L.* (2020) A SAM-I riboswitch with the ability to sense and respond to uncharged initiator tRNA. Nature Communications 11, 2794*为通讯作者)

  7. Li, Q., Zhang, S., Li, W., Ge, Z., Fan, C., & Gu, H.* (2020). Programming CircLigase Catalysis for DNA Rings and Topologies. Analytical Chemistry.*为通讯作者)

  8. Xia K, Shen J, Li Q, Fan C*, Gu H*. Near-Atomic Fabrication with Nucleic Acids. ACS Nano. 2020 Feb 25;14(2):1319-1337.*为通讯作者)

  9. Qinqin Hu; Hua Li; Lihua Wang; Hongzhou Gu*; Chunhai Fan*. “DNA Nanotechnology Enabled Drug Delivery systems.” Chemical Reviews 2018, doi: 10.1021/acs.chemrev.7b00663*为通讯作者)

  10. Qinqin Hu; Sheng Wang; Lihua Wang; Hongzhou Gu*; Chunhai Fan*. “DNA Nanostructure-Based Systems for Intelligent Delivery of Therapeutic Oligonucleotides.” Advanced Healthcare Materials 2018, doi: 10.1002/adhm.201701153.*为通讯作者)

  11. Hongzhou Gu*. “Single-molecule Genotyping with Nanoscale DNA Shape IDs.” Science China Chemistry 2017, 60, doi: 10.1007/s11426-017-9073-6.*为通讯作者)

  12. Hongzhou Gu; Kazuhiro Furukawa; Zasha Weinberg; Daniel F. Berenson; Ronald R. Breaker. “Small, Highly-active DNAs that Hydrolyze DNA.” Journal of the American Chemical Society 2013, 135, 9121-9129.

  13. Hongzhou Gu; Ronald R. Breaker. “Production of Single-stranded DNAs by Self-cleavage of Rolling-circle Amplification Products.” BioTechniques 2013, 54, 337-343.
    Highlighted as the cover story of
    BioTechniques June issue, 2013.

  14. Hongzhou Gu; Kazuhiro Furukawa; Ronald R. Breaker. “Engineered Allosteric Ribozymes that Sense the Bacterial Second Messenger c-di-GMP.” Analytical Chemistry 2012, 84, 4935-4941.

  15. Hongzhou Gu; Jie Chao; Shou-Jun Xiao; Nadrian C. Seeman. “A Proximity-Based Programmable DNA Nanoscale Assembly Line.” Nature 2010, 465, 202-205.
    Academic commentaries in
    Nature by Lloyd M. Smith: “Molecular robots on the move”.
    Highlighted in
    Nature Nanotechnology: “DNA nanomachines: On the right track”.
    Highlighted by the Editorial in
    Nature Nanotechnology: “Help from above”.
    Highlighted in
    Nature Methods: “Robotics on the nanoscale”.

  16. Hongzhou Gu; Wei Yang; Nadrian C. Seeman. “DNA Scissors Device Used to Measure MutS Binding to DNA Mis-Pairs.” Journal of the American Chemical Society 2010, 132, 4352-4357.

  17. Hongzhou Gu; Jie Chao; Shou-Jun Xiao; Nadrian C. Seeman. “Dynamic Patterning Programmed by DNA Tiles Captured on a DNA Origami Substrate.” Nature Nanotechnology 2009, 4, 245-248.
    Highlighted by the 2011 Focus in
    Nature Nanotechnology: “DNA nanotechnology”.

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