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  • 李大强

    博士,研究员,博士生导师
    地址:东安路131号,上海 200032
    电话:021-38197025
    邮箱:daqiangli1974@fudan.edu.cn

工作经历
1998年7月及2003年7月在重庆医科大学分别获得医学学士学位及医学博士学位。2003年8月至2009年10月先后在复旦大学附属肿瘤医院、美国凯斯西储大学(Case Western Reserve University)、德州大学安德森肿瘤中心(University of Texas M.D. Anderson Cancer Center)及乔治华盛顿大学(George Washington University)从事博士后研究工作。
教育经历
2009年11月起任乔治华盛顿大学生物化学及分子生物学系Faculty 及Assistant Research Professor,并于2013年7月升职为Associate Research Professor。2013年8月底回国任复旦大学生物医学研究院及肿瘤研究所PI,入选2013年上海高校特聘教授 。
研究方向
一直致力于肿瘤侵袭转移及治疗耐药的分子机制研究,为寻找干预肿瘤转移和治疗耐药的候选药物靶标提供线索,在Cancer Cell、Mol Cell、Cell Rep、Hepatology、J Cell Biol、Nat Commun、PNAS、Autophagy、Nucleic Acids Res、Cancer Res以及Cell Death Differ等国际期刊上发表SCI论文50余篇。目前担任Cancer Research等杂志编委以及Cancer Research等多个杂志的审稿人。
代表论文

1.Liu HY, Liu YY, Yang F, Zhang L, Zhang FL, Hu X*, Shao ZM*, Li DQ* (2020). Acetylation of MORC2 by NAT10 regulates cell-cycle checkpoint control and resistance to DNA-damaging chemotherapy and radiotherapy in breast cancer. Nucleic Acids Res [PMID: 32112098]

2.Zhang L, Li DQ* (2019). MORC2 regulates DNA damage response through a PARP1-dependent pathway. Nucleic Acids Res, 47(16): 8502-8520

3.Zhang FL, Cao JL, Xie HY, Sun R, Yang LF, Shao ZM*, Li DQ* (2018). Cancer-associated MORC2-mutant M276I regulates an hnRNPM-mediated CD44 splicing switch to promote invasion and metastasis in triple-negative breast cancer. Cancer Res, 78(20):5780-5792

4.Sun R, Xie HY, Qian JX, Huang YN, Yang F, Zhang FL*, Shao ZM*, Li DQ* (2018). FBXO22 possesses both protumorigenic and antimetastatic roles in breast cancer Progression. Cancer Res, 78(18):5274-5286

5.Yang LF, Yang F, Zhang FL, Xie YF, Hu ZX, Huang SL*, Shao ZM*, Li DQ* (2020). Discrete functional and mechanistic roles of CDYL2 transcript variants in breast cancer growth and metastasis. Theranostics (accepted)

6.Yang F, Xie HY, Yang LF, Zhang L, Zhang FL, Liu HY, Li DQ*, Shao ZM* (2020). Stabilization of MORC2 by estrogen and antiestrogens through GPER1-KAPCA-CMA pathway contributes to estrogen-induced proliferation and endocrine resistance of breast cancer cells. Autophagy (Published Online: 06 Sep 2019)

7.Yang YL, Zhang Y, Li DD, Zhang FL, Liu HY, Liao XH, Xie HY, Lu Q, Zhang L, Hong Q, Dong WJ, Li DQ*, Shao ZM* (2020). RNF144A functions as a tumor suppressor in breast cancer through ubiquitin ligase activity-dependent regulation of stability and oncogenic functions of HSPA2. Cell Death Differ, 27(3):1105-1118

8.Li DQ*, Pakala SB*, Reddy SD, Peng S, Balasenthil1 S, Lee CC, Rea MA, Kumar R. Metastasis-associated protein 1 is an integral component of the circadian molecular machinery. Nat Commun, 2013; 4: 2545 (*Contributed equally)

9.Li DQ*, Nair SS, Ohshiro K, Kumar A, Nair VS, Pakala SB, Reddy SD, Gajula RP, Eswaran J, Aravind L, Kumar R*. MORC2 signaling integrates phosphorylation-dependent, ATPase-coupled chromatin remodeling during the DNA damage response. Cell Rep, 2012; 2: 1657–1669 (*Co-corresponding authors)

10.Li DQ, Pakala SB, Reddy SD, Ohshiro K, Zhang JX, Wang L, Zhang Y, de Alborán IM, Pillai MR, Eswaran J, Kumar R. Bidirectional autoregulatory mechanism of metastasis associated protein 1-alternative reading frame pathway in oncogenesis. Proc Natl Acad Sci U S A, 2011; 108: 8791-8796

11.Li DQ, Ohshiro K, Reddy SD, Pakala SB, Lee MH, Zhang Y, Rayala SK, Kumar R. E3 ubiquitin ligase COP1 regulates the stability and functions of MTA1. Proc Natl Acad Sci U S A, 2009; 106: 17493-17498

12.Zhang JX*, Li DQ*, He AR, Motwani M, Vasiliou V, Eswaran J, Mishra L, Kumar R. Synergistic inhibition of hepatocellular carcinoma growth by cotargeting chromatin modifying enzymes and poly (ADP-ribose) polymerases. Hepatology, 2012; 55: 1840-1851 (*Contributed equally)

13。Molli PR*, Li DQ*, Bagheri-Yarmand R, Pakala SB, Katayama H, Sen S, Iyer J, Chernoff J, Tsai MY, Nair SS, Kumar R. Arpc1b, a centrosomal protein, is both an activator and substrate of Aurora A. J Cell Biol, 2010; 190: 101-114 (Comment in Nat Rev Mol Cell Biol, 2010; 11: 542) (*Contributed equally)

14.Miao H, Li DQ, Mukherjee A, Guo H, Petty A, Cutter J, Basilion JP, Sedor J, Wu J, Danielpour D, Sloan AE, Cohen ML, Wang B. EphA2 mediates ligand-dependent inhibition and ligand-independent promotion of cell migration and invasion via a reciprocal regulatory loop with Akt. Cancer Cell, 2009; 16: 9-20 (Featured in Nature, 2009; 461:149 under Research Highlights)

15.Nair SS, Li DQ, Kumar R. A core chromatin remodeling factor instructs global chromatin signaling through multivalent reading of nucleosome codes. Mol Cell, 2013; 49: 704–718

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