医学遗传学和基因组学研究
博士，青年研究员，博士生导师，复旦大学附属儿科医院特聘教授
地址：万源路399号，上海，201102
邮箱：mxqian@fudan.edu.cn
主要专注于医学遗传学、表观遗传学和功能基因组学研究，通过灵活地运用各种组学手段，深入的生物信息分析和数据挖掘，并有机结合下游基因功能研究，探索遗传性疾病的发病机制和预后风险因素。其研究成果主要包括多个儿童白血病遗传易感及致病基因的鉴定（TP53，IKZF1，et al.），儿童白血病亚型的界定（ZNF384-rearranged），儿童肿瘤基因多种调控模式的研究，单碱基分辨率的DNA损伤变异检测方法开发等。迄今已在JCO, Cancer Cell, Nature Genetics, Lancet Oncology, Blood, Nat Commun, Genome Research, JNCI, NAR, JACS等国际高水平学术期刊发表SCI论文40余篇，其中（共同）第一作者或通讯作者20余篇。 受聘上海高校特聘教授，被授予“上海特聘专家”称号，入选国家级人才项目，曾获美国癌症研究会年度青年学者奖等，受国家自然科学基金、国家重点研发计划及多项国家和地方人才计划等项目支持。
本课题组长期招收博士后及科研助理，待遇30W+，有意者随时联系。
代表论文（#第一作者；*通讯作者）
1.Liu S*, Xiang Y, Wang B, Gao C, Chen Z, Xie S, Wu J, Liu Y, Zhao X, Yang C, Yue Z, Wang L, Wen X, Zhang R, Zhang F, Xu H, Zhai X, Zheng H, Zhang H, Qian M*. USP1 promotes the aerobic glycolysis and progression of T-cell acute lymphoblastic leukemia via PLK1/LDHA axis. Blood Adv. 2023 Mar 13:bloodadvances.2022008284. PMID: 36912760
2.Zhu Y#, Tan Y#, Li L#, Xiang Y, Huang Y, Zhang X, Yin J, Li J, Lan F, Qian M*, Hu J*. Genome-wide mapping of protein-DNA damage interaction by PADD-seq. Nucleic Acids Res. 2023 Jan 30:gkad008. PMID: 36715337
3.Su N#, Li Z#, Yang J, Fu Y, Zhu X, Miao H, Yu Y, Jiang W, Le J, Qian X, Wang H, Qian M*, Zhai X*. Revealing the intratumoral heterogeneity of non-DS acute megakaryoblastic leukemia in single-cell resolution. Front Oncol. 2022 Aug 8;12:915833. PMID: 36003795.
4.Zhao X#, Qian M#, Goodings C, Zhang Y, Yang W, Wang P, Xu B, Tian C, Pui CH, Hunger SP, Raetz EA, Devidas M, Relling MV, Loh ML, Savic D, Li C, Yang JJ. Molecular Mechanisms of ARID5B-Mediated Genetic Susceptibility to Acute Lymphoblastic Leukemia. J Natl Cancer Inst. 2022 Sep 9;114(9):1287-1295. PMID: 35575404.
5.He H#, Li Z#, Lu J, Qiang W, Jiang S, Xu Y, Fu W, Zhai X, Zhou L, Qian M*, Du J*. Single-cell RNA-seq reveals clonal diversity and prognostic genes of relapsed multiple myeloma. Clin Transl Med. 2022 Mar;12(3):e757. PMID: 35297204.
6.Qian J#, Li Z#, Pei K, Li Z, Li C, Yan M, Qian M*, Song Y*, Zhang H*, He Y*. Effects of NRAS Mutations on Leukemogenesis and Targeting of Children With Acute Lymphoblastic Leukemia. Front Cell Dev Biol. 2022 Feb 8;10:712484. PMID: 35211470.
7.Jiang L#, Yin J#, Qian M#, Rong S, Zhang S, Chen K, Zhao C, Tan Y, Guo J, Chen H, Gao S, Liu T, Liu Y, Shen B, Yang J, Zhang Y, Meng FL, Hu J*, Ma H*, Chen YH*. UdgX-Mediated Uracil Sequencing at Single-Nucleotide Resolution. J Am Chem Soc. 2022 Jan 16. PMID: 35037455.
8.An J#, Yin M#, Yin J#, Wu S, Selby CP, Yang Y, Sancar A, Xu GL, Qian M*, Hu J*. Genome-wide analysis of 8-oxo-7,8-dihydro-2'-deoxyguanosine at single-nucleotide resolution unveils reduced occurrence of oxidative damage at G-quadruplex sites. Nucleic Acids Res. 2021 Dec 2;49(21):12252-12267. PMID: 34788860.
9.Li C, Liang W, He Y, Zhao X, Qian J, Li Z, Jiang C, Zheng Q, Fu X, Zhang W, Liu H, Sun X*, Qian M*, Zhang H*. Inherited GATA3 variant associated with positive minimal residual disease in childhood B-cell acute lymphoblastic leukemia via asparaginase resistance. Clin Transl Med. 2021 Aug;11(8):e507. PMID: 34459144.
10.Liu H#, Li Z#, Qiu F#, Li C, Lin X, He Y, Qian M*, Song Y*, Zhang H*. Association Between NR3C1 Mutations and Glucocorticoid Resistance in Children With Acute Lymphoblastic Leukemia. Front Pharmacol. 2021 Mar 29;12:634956.PMID: 33854435.
11.Li Z#, Wang H#, Dong R, Man J, Sun L, Qian X, Zhu X, Cao P, Yu Y, Le J, Fu Y, Wang P, Jiang W, Shen C, Ma Y, Chen L, Xu Y, Shi J, Zhang H, Qian M*, Zhai X*. Single-Cell RNA-seq Reveals Characteristics of Malignant Cells and Immune Microenvironment in Subcutaneous Panniculitis-Like T-Cell Lymphoma. Front Oncol. 2021 Mar 18;11:611580. PMID: 33816243.
12.Lee SHR#, Qian M#*, Yang W, Diedrich JD, Raetz E, Yang W, Dong Q, Devidas M, Pei D, Yeoh A, Cheng C, Pui CH, Evans WE, Mullighan CG, Hunger SP, Savic D, Relling MV, Loh ML, Yang JJ*. Genome-wide association study of susceptibility loci for TCF3-PBX1 acute lymphoblastic leukemia in children. J Natl Cancer Inst. 2021 Jul 1;113(7):933-937. PMID: 32882024.
13.Zheng Q#, Jiang C#, Liu H, Hao W, Wang P, Huang H, Li Z, Qian J, Qian M*, Zhang H*. Down-Regulated FOXO1 in Refractory/Relapse Childhood B-Cell Acute Lymphoblastic Leukemia. Front Oncol. 2020 Nov 11;10:579673. PMID: 33262946.
14.Vijayakrishnan J#, Qian M#, Studd JB, Yang W, Kinnersley B, Law PJ, Broderick P, Raetz EA, Allan J, Pui CH, Vora A, Evans WE, Moorman A, Yeoh A, Yang W, Li C, Bartram CR, Mullighan CG, Zimmerman M, Hunger SP, Schrappe M, Relling MV, Stanulla M, Loh ML, Houlston RS*, Yang JJ*. Identification of four novel associations for B-cell acute lymphoblastic leukaemia risk. Nat Commun. 2019 Nov 25;10(1):5348. PMID: 31767839.
15.Qian M, Zhao X, Devidas M, Yang W, Gocho Y, Smith C, Gastier-Foster JM, Li Y, Xu H, Zhang S, Jeha S, Zhai X, Sanda T, Winter SS, Dunsmore KP, Raetz EA, Carroll WL, Winick NJ, Rabin KR, Zweidler-Mckay PA, Wood B, Pui CH, Evans WE, Hunger SP, Mullighan CG, Relling MV, Loh ML, Yang JJ*. Genome-Wide Association Study of Susceptibility Loci for T-Cell Acute Lymphoblastic Leukemia in Children. J Natl Cancer Inst. 2019 Dec 1;111(12):1350-1357. PMID: 30938820.
16.Qian M#, Xu H#, Perez-Andreu V, Roberts KG, Zhang H, Yang W, Zhang S, Zhao X, Smith C, Devidas M, Gastier-Foster JM, Raetz E, Larsen E, Burchard EG, Winick N, Bowman WP, Martin PL, Borowitz M, Wood B, Antillon-Klussmann F, Pui CH, Mullighan CG, Evans WE, Hunger SP, Relling MV, Loh ML, and Yang JJ*. Novel susceptibility variants at the ERG locus for childhood acute lymphoblastic leukemia in Hispanics. Blood.2019 Feb 14;133(7):724-729. PMID: 30510082.
17.Churchman ML#, Qian M#, Te Kronnie G#, Zhang R, Yang W, Zhang H, Lana T, Tedrick P, Baskin R, Verbist K, Peters JL, Devidas M, Larsen E, Moore IM, Gu Z, Qu C, Yoshihara H, Porter SN, Pruett-Miller SM, Wu G, Raetz E, Martin PL, Bowman WP, Winick N, Mardis E, Fulton R, Stanulla M, Evans WE, Relling MV, Pui CH, Hunger SP, Loh ML, Handgretinger R, Nichols KE, Yang JJ*, Mullighan CG*. Germline Genetic IKZF1 Variation and Predisposition to Childhood Acute Lymphoblastic Leukemia. Cancer Cell. 2018 May 14;33(5):937-948.e8. PMID: 29681510.
18.Qian M, Cao X, Devidas M, Yang W, Cheng C, Dai Y, Carroll A, Heerema NA, Zhang H, Moriyama T, Gastier-Foster JM, Xu H, Raetz E, Larsen E, Winick N, Bowman WP, Martin PL, Mardis ER, Fulton R, Zambetti G, Borowitz M, Wood B, Nichols KE, Carroll WL, Pui CH, Mullighan CG, Evans WE, Hunger SP, Relling MV, Loh ML, Yang JJ*. TP53 Germline Variations Influence the Predisposition and Prognosis of B-Cell Acute Lymphoblastic Leukemia in Children. J Clin Oncol. 2018 Jan 4; JCO2017755215. PMID: 29300620.
19.Li L#, Qian M#, Chen IH, Finkelstein D, Onar-Thomas A, Johnson M, Calabrese C, Bahrami A, López-Terrada DH, Yang JJ, Tao WA, Zhu L*. Acquisition of Cholangiocarcinoma Traits during Advanced Hepatocellular Carcinoma Development in Mice. Am J Pathol. 2017 Dec 14; PMID: 29248454.
20.Hu S#*, Qian M#, Zhang H#, Guo Y#, Yang J, Zhao X, He H, Lu J, Pan J, Chang M, Du G, Lin TN, Kham SK, Quah TC, Ariffin H, Tan AM, Cheng Y, Li C, Yeoh AE, Pui CH, Skanderup AJ, Yang JJ*. Whole-genome noncoding sequence analysis in T-cell acute lymphoblastic leukemia identifies oncogene enhancer mutations. Blood. 2017 Jun 15;129(24):3264-3268. PMID: 28408461.
21.Qian M#, Zhang H#, Kham SK, Liu S, Jiang C, Zhao X, Lu Y, Goodings C, Lin TN, Zhang R, Moriyama T, Yin Z, Li Z, Quah TC, Ariffin H, Tan AM, Shen S, Bhojwani D, Hu S, Chen S, Zheng H, Pui CH, Yeoh AE*, Yang JJ*. Whole-transcriptome sequencing identifies a distinct subtype of acute lymphoblastic leukemia with predominant genomic abnormalities of EP300 and CREBBP. Genome Res. 2017 Feb;27(2):185-195. PMID: 27903646.
22.Qian M, Jin W, Zhu X, Jia X, Yang X, Du Y, Wang K*, Zhang J*. Structurally differentiated cis-elements that interact with PU.1 are functionally distinguishable in acute promyelocytic leukemia. J Hematol Oncol. 2013 Apr 2;6:25. PMID: 23547873.
