全聘课题组长
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  • 钱茂祥

    儿童肿瘤的遗传学和基因组学研究
    博士,青年研究员,复旦大学附属儿科医院兼职教授
    地址:万源路399号,上海,201102
    邮箱:mxqian@fudan.edu.cn


工作经历
青年研究员,复旦大学, 生物医学研究院/儿科医院 (2018.9-今)
博士后,美国圣裘德儿童研究医院(2014.6-2018.8)
高级研究员/生信组长,上海药明康德基因组学中心(现药明明码)(2011.9-2014.5)

教育经历
遗传学博士,中国科学院上海生命科学研究院 / 中国科学院大学 (2004.9-2011.5)
理学学士,浙江大学,生命科学院(2000.9-2004.7)
研究方向
课题组主要专注于儿童肿瘤的遗传学、表观遗传学和功能基因组学研究,通过灵活地运用各种组学手段,深入的生物信息分析和数据挖掘,并有机结合下游基因功能研究,探索儿童肿瘤的发病机制和预后风险因素。其研究成果主要包括多个儿童白血病遗传易感及致病基因的鉴定(ETV6,TP53,IKZF1,et al.),儿童白血病亚型的界定(ZNF384-rearranged),儿童肿瘤基因多种调控模式的研究等。迄今已在Cancer Cell, Lancet Oncology, Journal of Clinical Oncology, Genome Research, Blood等国际高水平学术期刊发表SCI论文14篇,其中第一作者(包括共同第一作者)7篇。 曾获美国癌症研究会年度青年学者奖(Scholar-in-Training Award)和美国血液学学会年度突出摘要奖(Abstract Achievement Award)等。
代表论文

1.Qian M#, Xu H#, Perez-Andreu V, Roberts KG, Zhang H, Yang W, Zhang S, Zhao X, Smith C, Devidas M, Gastier-Foster JM, Raetz E, Larsen E, Burchard EG, Winick N, Bowman WP, Martin PL, Borowitz M, Wood B, Antillon-Klussmann F, Pui CH, Mullighan CG, Evans WE, Hunger SP, Relling MV, Loh ML, and Yang JJ. Novel susceptibility variants at the ERG locus for childhood acute lymphoblastic leukemia in Hispanics. Blood. 2018. (Accepted).

2.Churchman ML#, Qian M#, Te Kronnie G#, Zhang R, Yang W, Zhang H, Lana T, Tedrick P, Baskin R, Verbist K, Peters JL, Devidas M, Larsen E, Moore IM, Gu Z, Qu C, Yoshihara H, Porter SN, Pruett-Miller SM, Wu G, Raetz E, Martin PL, Bowman WP, Winick N, Mardis E, Fulton R, Stanulla M, Evans WE, Relling MV, Pui CH, Hunger SP, Loh ML, Handgretinger R, Nichols KE, Yang JJ*, Mullighan CG*. Germline Genetic IKZF1 Variation and Predisposition to Childhood Acute Lymphoblastic Leukemia. Cancer Cell. 2018 May 14;33(5):937-948.e8. doi: 10.1016/j.ccell.2018.03.021. Epub 2018 Apr 19. PMID: 29681510.

3.Qian M, Cao X, Devidas M, Yang W, Cheng C, Dai Y, Carroll A, Heerema NA, Zhang H, Moriyama T, Gastier-Foster JM, Xu H, Raetz E, Larsen E, Winick N, Bowman WP, Martin PL, Mardis ER, Fulton R, Zambetti G, Borowitz M, Wood B, Nichols KE, Carroll WL, Pui CH, Mullighan CG, Evans WE, Hunger SP, Relling MV, Loh ML, Yang JJ. TP53 Germline Variations Influence the Predisposition and Prognosis of B-Cell Acute Lymphoblastic Leukemia in Children. J Clin Oncol. 2018 Jan 4; JCO2017755215. PMID: 29300620.

4.Li L#, Qian M#, Chen IH, Finkelstein D, Onar-Thomas A, Johnson M, Calabrese C, Bahrami A, López-Terrada DH, Yang JJ, Tao WA, Zhu L. Acquisition of Cholangiocarcinoma Traits during Advanced Hepatocellular Carcinoma Development in Mice. Am J Pathol. 2017 Dec 14; PMID: 29248454.

5.Hu S#, Qian M#, Zhang H#, Guo Y#, Yang J, Zhao X, He H, Lu J, Pan J, Chang M, Du G, Lin TN, Kham SK, Quah TC, Ariffin H, Tan AM, Cheng Y, Li C, Yeoh AE, Pui CH, Skanderup AJ, Yang JJ. Whole-genome noncoding sequence analysis in T-cell acute lymphoblastic leukemia identifies oncogene enhancer mutations. Blood. 2017 Jun 15;129(24):3264-3268. PMID: 28408461.

6.Qian M#, Zhang H#, Kham SK, Liu S, Jiang C, Zhao X, Lu Y, Goodings C, Lin TN, Zhang R, Moriyama T, Yin Z, Li Z, Quah TC, Ariffin H, Tan AM, Shen S, Bhojwani D, Hu S, Chen S, Zheng H, Pui CH, Yeoh AE*, Yang JJ*. Whole-transcriptome sequencing identifies a distinct subtype of acute lymphoblastic leukemia with predominant genomic abnormalities of EP300 and CREBBP. Genome Res. 2017 Feb;27(2):185-195. PMID: 27903646.

7.Zhang Y#, Gao Y#, Zhang H#, Zhang J, He F, Hnízda A, Qian M, Liu X, Gocho Y, Pui CH, Cheng T, Wang Q, Yang JJ*, Zhu X*, Liu X*. PDGFRB mutation and tyrosine kinase inhibitor resistance in Ph-like acute lymphoblastic leukemia. Blood, 2018 May 17;131(20):2256-2261. PMID: 29434033.

8.Moriyama T#, Metzger ML#, Wu G#, Nishii R, Qian M, Devidas M, Yang W, Cheng C, Cao X, Quinn E, Raimondi S, Gastier-Foster JM, Raetz E, Larsen E, Martin PL, Bowman WP, Winick N, Komada Y, Wang S, Edmonson M, Xu H, Mardis E, Fulton R, Pui CH, Mullighan C, Evans WE, Zhang J, Hunger SP, Relling MV, Nichols KE, Loh ML, Yang JJ. Germline genetic variation in ETV6 and risk of childhood acute lymphoblastic leukaemia: a systematic genetic study. Lancet Oncol. 2015 Dec;16(16):1659-66. doi: 10.1016/S1470-2045(15)00369-1. PMID: 26522332.

9.Xu H#, Zhang H#, Yang W, Yadav R, Morrison AC, Qian M, Devidas M, Liu Y, Perez-Andreu V, Zhao X, Gastier-Foster JM, Lupo PJ, Neale G, Raetz E, Larsen E, Bowman WP, Carroll WL, Winick N, Williams R, Hansen T, Holm JC, Mardis E, Fulton R, Pui CH, Zhang J, Mullighan CG, Evans WE, Hunger SP, Gupta R, Schmiegelow K, Loh ML, Relling MV, Yang JJ. Inherited coding variants at the CDKN2A locus influence susceptibility to acute lymphoblastic leukaemia in children. Nat Commun. 2015 Jun 24;6:7553. doi: 10.1038/ncomms8553. PMID: 26104880.

10.Fang DD#, Zhang B#, Gu Q, Lira M, Xu Q, Sun H, Qian M, Sheng W, Ozeck M, Wang Z, Zhang C, Chen X, Chen KX, Li J, Chen SH, Christensen J, Mao M, Chan CC. HIP1-ALK, a novel ALK fusion variant that responds to crizotinib. J Thorac Oncol. 2014 Mar;9(3):285-94. doi: 10.1097/JTO.0000000000000087. PMID: 24496003.

11.Qian M, Jin W, Zhu X, Jia X, Yang X, Du Y, Wang K, Zhang J. Structurally differentiated cis-elements that interact with PU.1 are functionally distinguishable in acute promyelocytic leukemia. J Hematol Oncol. 2013 Apr 2;6:25. doi: 10.1186/1756-8722-6-25. PMID: 23547873.

12.Zhu X#, Zhang H#, Qian M, Zhao X, Yang W, Wang P, Zhang J, Wang K. The significance of low PU.1 expression in patients with acute promyelocytic leukemia. J Hematol Oncol. 2012 May 8;5:22. doi: 10.1186/1756-8722-5-22. PMID: 22569057.

13.Wang K#, Wang P#, Shi J#, Zhu X#, He M, Jia X, Yang X, Qiu F, Jin W, Qian M, Fang H, Mi J, Yang X, Xiao H, Minden M, Du Y, Chen Z, Zhang J. PML/RARalpha targets promoter regions containing PU.1 consensus and RARE half sites in acute promyelocytic leukemia. Cancer Cell. 2010 Feb 17;17(2):186-97. doi: 10.1016/j.ccr.2009.12.045. PMID: 20159610.


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