全聘课题组长
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  • 桑庆

    博士,研究员,博士生导师
    地址:上海市徐汇区东安路131号,上海200032
    电话:021-54237283
    邮箱:sangqing@fudan.edu.cn
    实验室主页:https://reprod-genet.fudan.edu.cn

工作经历
研究员,复旦大学,生物医学研究院(2022.12-至今)
副研究员,复旦大学,生物医学研究院(2020.5-2022.12)
副研究员,复旦大学,生命科学学院(2018.1-2020.4)
青年副研究员 复旦大学,生命科学学院(2015.12-2017.12)
博士后 复旦大学,生物医学研究院(2013.7-2015.11)
教育经历
博士 复旦大学 生物医学研究院(2010.9-2013.6)
硕士 中山大学 生命科学学院(2007.9-2010.7)
学士 烟台大学 海洋学院 (2003.9-2007.7)
所获人才项目
国家杰出青年科学基金(2023)
国家优秀青年科学基金(2018)
上海市优秀学术带头人(2021)
所获奖项
上海市科学技术奖自然科学一等奖(第二完成人,2020)
全国妇幼健康科技奖自然科学一等奖 (第二完成人,2017)
中国动物学会生殖生物学分会第二届青年科技奖(2017)
全国妇幼健康科技奖自然科学二等奖 (第二完成人,2015)
研究方向
聚焦女性生殖疾病的遗传学。重点围绕人类卵子受精异常及早期胚胎停滞的遗传机制展开研究。自2013年以来,以第一作者或通讯作者 (含并列) 在N Engl J Med, Science, J Clin Invest, Sci Transl Med, Genom Biol, Am J Hum Genet等期刊发表SCI论文40余篇。发现启动人类卵母细胞纺锤体组装关键结构huoMTOC;阐明人类合子分裂失败的首个致病基因BTG4及机制;揭示新发突变在人卵母细胞成熟和早期胚胎发育中的关键作用;发现核转运蛋白缺陷导致人类早期胚胎停滞的新机制。相关分子指标已被广泛应用于临床不孕患者检测中。
代表论文

1.Wang W, Miyamoto Y, Chen B, Shi J, Diao F, Zheng W, Li Q, Yu L, Li L, Xu Y, Wu L, Mao X, Fu J, Li B, Yan Z, Shi R, Xue X, Mu J, Zhang Z, Wu T, Zhao L, Wang W, Zhou Z, Dong J, Li Q, Jin L, He L, Sun X, Lin G, Kuang Y*, Wang L* and Sang Q*.Karyopherin α deficiency contributes to human preimplantation embryo arrest. J Clin Invest. 2023 Jan 17;133(2):e159951.

2.Li Q, Zhao L, Zeng Y, Kuang Y, Guan Y, Chen B, Xu S, Tang B, Wu L, Mao X, ; Sun X, Shi J, Xu P, Diao F, Xue S, Bao S, Meng  Q, Yuan P, Wang W, Ma N, Song D, Xu B, Dong J, Mu J, Zhang Z, Fan H, Gu H, Li Q, He L, Jin L, Wang L*, Sang Q*, Large-scale analysis of de novo mutations identifies risk genes for female infertility characterized by oocyte and early embryo defects. Genome Biol. 2023 Apr 06;24(68).

3.Wu T, Dong J, Fu J, Kuang Y, Chen B, Gu H, Luo Y, Gu R, Zhang M, Li W, Dong X, Sun X*, Sang Q*, Wang L*. The mechanism of acentrosomal spindle assembly in human oocytes. Science. 2022 Nov 18; 378(6621): eabq7361.

4.Sang Q, Ray PF, Wang L*. Understanding the genetics of human infertility. Science. 2023 Apr 14;380(6641):158-163.

5.Wang L*, Sang Q*. MOS is a novel genetic marker for human early embryonic arrest and fragmentation. EMBO Mol Med. 2021 Dec 7;13(12):e15323.

6.Wang W, Wang W, Xu Y, Shi J, Fu J, Chen B, Mu J, Zhang Z, Zhao L, Lin J, Du J, Li Q, He L, Jin L, Sun X*, Wang L*, Sang Q*. FBXO43 variants in patients with female infertility characterized by early embryonic arrest. Hum Reprod. 2021 Jul 19;36(8):2392-2402.  

7.Dong J, Zhang H, Mao X, Zhu J, Li D, Fu J, Hu J, Wu L, Chen B, Sun Y, Mu J, Zhang Z, Sun X, Zhao L, Wang W, Wang W, Zhou Z, Zeng Y, Du J, Li Q, He L, Jin L, Kuang Y, Wang L*, Sang Q*. Novel biallelic mutations in MEI1: expanding the phenotypic spectrum to human embryonic arrest and recurrent implantation failure. Hum Reprod. 2021 Jul 19;36(8):2371-2381.  

8.Zheng W, Zhou Z, Sha Q, Niu X, Sun X, Shi J, Zhao L, Zhang S, Dai J, Cai S, Meng F, Hu L, Gong F, Li X, Fu J, Shi R, Lu G, Chen B, Fan H, Wang L, Lin G*, Sang Q*. Homozygous mutations in BTG4 cause zygotic cleavage failure and female infertility. Am J Hum Genet. 2020 Jul 2;107(1):24-33.

9.Zhao L, Xue S, Yao Z, Shi J, Chen B, Wu L, Sun L, Xu Y, Yan Z, Li B, Mao X, Fu J, Zhang Z, Mu J, Wang W, Du J, Liu S, Dong J, Wang W, Li Q, He L, Jin L, Liang X, Kuang Y, Sun X, Wang L*, Sang Q*. Biallelic mutations in CDC20 cause female infertility characterized by abnormalities in oocyte maturation and early embryonic development. Protein Cell. 2020 Dec;11(12):921-927.

10.Zhang Z, Li B, Fu J, Li R, Diao F, Li C, Chen B, Du J, Zhou Z, Mu J, Yan Z, Wu L, Liu S, Wang W, Zhao L, Dong J, He L, Liang X, Kuang Y, Sun X, Sang Q*, Wang L*. Bi-allelic missense pathogenic variants in TRIP13 cause female infertility characterized by oocyte maturation arrest. Am J Hum Genet. 2020 Jul 2;107(1):15-23.

11.Wang W, Dong J, Chen B, Du J, Kuang Y, Sun X, Fu J, Li B, Mu J, Zhang Z, Zhou Z, Lin Z, Wu L, Yan Z, Mao X, Li Q, He L, Wang L*, Sang Q*. Homozygous mutations in REC114 cause female infertility characterised by multiple pronuclei formation and early embryonic arrest. J Med Genet. 2020 Mar;57(3):187-194.

12.Sang Q*, Zhang Z, Shi J, Sun X, Li B, Yan Z, Xue S, Ai A, Lyu Q, Li W, Zhang J, Wu L, Mao X, Chen B, Mu J, Li Q, Du J, Sun Q, Jin L, He L, Zhu S, Kuang Y*, Wang L*. A pannexin 1 channelopathy causes human oocyte death. Sci Transl Med. 2019 Mar 27;11(485): eaav8731.

13.Mu J, Wang W, Chen B, Wu L, Li B, Mao X, Zhang Z, Fu J, Kuang Y, Sun X, Li Q, Jin L, He L, Sang Q*, Wang L*. Mutations in NLRP2 and NLRP5 cause female infertility characterised by early embryonic arrest. J Med Genet. 2019 Jul;56(7):471-480.

14.Sang Q*, Li B, Kuang Y, Wang X, Zhang Z, Chen B, Wu L, Lyu Q, Fu Y, Yan Z, Mao X, Xu Y, Mu J, Li Q, Jin L, He L, Wang L*. Homozygous mutations in WEE2 cause fertilization failure and female infertility. Am J Hum Genet. 2018 Apr 5;102(4):649-657.

15.Chen B, Zhang Z, Sun X, Kuang Y, Mao X, Wang X, Yan Z, Li B, Xu Y, Yu M, Fu J, Mu J, Zhou Z, Li Q, Jin L, He L, Sang Q*, Wang L*. Biallelic mutations in PATL2 cause female infertility characterized by oocyte maturation arrest. Am J Hum Genet. 2017 Oct 5;101(4):609-615.

16.Chen B, Li B, Li D, Yan Z, Mao X, Xu Y, Mu J, Li Q, Jin L, He L, Kuang Y, Sang Q*, Wang L*. Novel mutations and structural deletions in TUBB8: expanding mutational and phenotypic spectrum of patients with arrest in oocyte maturation, fertilization or early embryonic development. Hum Reprod. 2017 Feb;32(2):457-464.

17.Feng R#Sang Q#, Kuang Y#, Sun X#, Yan Z#, Zhang S#, Shi J, Tian G, Luchniak A, Fukuda Y, Li B, Yu M, Chen J, Xu Y, Guo L, Qu R, Wang X, Sun Z, Liu M, Shi H, Wang H, Feng Y, Shao R, Chai R, Li Q, Xing Q, Zhang R, Nogales E, Jin L, He L, Gupta ML Jr, Cowan NJ*, Wang L*. Mutations in TUBB8 and human oocyte meiotic arrest. N Engl J Med. 2016 Jan 21;374(3):223-32.

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