全聘课题组长
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  • 桑庆

    博士,副研究员,博士生导师
    地址:上海市徐汇区东安路131号科研2号楼A3-029室,上海200032
    电话:021-54237283
    邮箱:sangqing@fudan.edu.cn
    实验室主页:https://reprod-genet.fudan.edu.cn

工作经历
副研究员,复旦大学,生物医学研究院(2020.5-至今)
副研究员,复旦大学,生命科学学院(2018.1-2020.4)
青年副研究员 复旦大学,生命科学学院(2015.12-2017.12)
博士后 复旦大学,生物医学研究院(2013.7-2015.11)
教育经历
博士 复旦大学 生物医学研究院(2010.9-2013.6)
硕士 中山大学 生命科学学院(2007.9-2010.7)
学士 烟台大学 海洋学院 (2003.9-2007.7)
所获人才项目
国家自然科学基金优秀青年基金(2018)
上海市优秀学术带头人(2021)
所获奖项
上海市科学技术奖自然科学一等奖(第二完成人,2020)
全国妇幼健康科技奖自然科学一等奖 (第二完成人,2017)
中国动物学会生殖生物学分会第二届青年科技奖(2017)
全国妇幼健康科技奖自然科学二等奖 (第二完成人,2015)
研究方向
女性生殖疾病的遗传学研究。重点围绕人类卵子受精异常、早期胚胎停育及多囊卵巢综合征的遗传学基础展开研究。 主要通过遗传学手段寻找受精和胚胎发育异常相关致病基因,并进行分子机制研究和干预策略探索。自2013年以来,以第一作者或通讯作者 (含并列) 在N Engl J Med,Sci Transl Med,Am J Hum Genet,Hum Mol Genet,J Clin Endocrinol Metab,J Med Genet等国际期刊上发表SCI论文35篇。发现并命名了新的孟德尔遗传病“卵子死亡”,鉴定出致病基因PANX1并进行了分子机制研究,为患者干预奠定基础。分别发现受精失败和合子不分裂的突变基因WEE2及BTG4,研究了致病机制并进行了干预探索。
代表论文

1.Wang L*, Sang Q*. MOS is a novel genetic marker for human early embryonic arrest and fragmentation. EMBO Mol Med. 2021 Dec 7;13(12):e15323.

2.Wang W, Wang W, Xu Y, Shi J, Fu J, Chen B, Mu J, Zhang Z, Zhao L, Lin J, Du J, Li Q, He L, Jin L, Sun X*, Wang L*, Sang Q*. FBXO43 variants in patients with female infertility characterized by early embryonic arrest. Hum Reprod. 2021 Jul 19;36(8):2392-2402.  

3.Dong J, Zhang H, Mao X, Zhu J, Li D, Fu J, Hu J, Wu L, Chen B, Sun Y, Mu J, Zhang Z, Sun X, Zhao L, Wang W, Wang W, Zhou Z, Zeng Y, Du J, Li Q, He L, Jin L, Kuang Y, Wang L*, Sang Q*. Novel biallelic mutations in MEI1: expanding the phenotypic spectrum to human embryonic arrest and recurrent implantation failure. Hum Reprod. 2021 Jul 19;36(8):2371-2381.  

4.Zheng W, Zhou Z, Sha Q, Niu X, Sun X, Shi J, Zhao L, Zhang S, Dai J, Cai S, Meng F, Hu L, Gong F, Li X, Fu J, Shi R, Lu G, Chen B, Fan H, Wang L, Lin G*, Sang Q*. Homozygous mutations in BTG4 cause zygotic cleavage failure and female infertility. Am J Hum Genet. 2020 Jul 2;107(1):24-33.

5.Zhao L, Xue S, Yao Z, Shi J, Chen B, Wu L, Sun L, Xu Y, Yan Z, Li B, Mao X, Fu J, Zhang Z, Mu J, Wang W, Du J, Liu S, Dong J, Wang W, Li Q, He L, Jin L, Liang X, Kuang Y, Sun X, Wang L*, Sang Q*. Biallelic mutations in CDC20 cause female infertility characterized by abnormalities in oocyte maturation and early embryonic development. Protein Cell. 2020 Dec;11(12):921-927.

6.Zhang Z, Li B, Fu J, Li R, Diao F, Li C, Chen B, Du J, Zhou Z, Mu J, Yan Z, Wu L, Liu S, Wang W, Zhao L, Dong J, He L, Liang X, Kuang Y, Sun X, Sang Q*, Wang L*. Bi-allelic missense pathogenic variants in TRIP13 cause female infertility characterized by oocyte maturation arrest. Am J Hum Genet. 2020 Jul 2;107(1):15-23.

7.Wang W, Dong J, Chen B, Du J, Kuang Y, Sun X, Fu J, Li B, Mu J, Zhang Z, Zhou Z, Lin Z, Wu L, Yan Z, Mao X, Li Q, He L, Wang L*, Sang Q*. Homozygous mutations in REC114 cause female infertility characterised by multiple pronuclei formation and early embryonic arrest. J Med Genet. 2020 Mar;57(3):187-194.

8.Sang Q*, Zhang Z, Shi J, Sun X, Li B, Yan Z, Xue S, Ai A, Lyu Q, Li W, Zhang J, Wu L, Mao X, Chen B, Mu J, Li Q, Du J, Sun Q, Jin L, He L, Zhu S, Kuang Y*, Wang L*. A pannexin 1 channelopathy causes human oocyte death. Sci Transl Med. 2019 Mar 27;11(485): eaav8731.

9.Mu J, Wang W, Chen B, Wu L, Li B, Mao X, Zhang Z, Fu J, Kuang Y, Sun X, Li Q, Jin L, He L, Sang Q*, Wang L*. Mutations in NLRP2 and NLRP5 cause female infertility characterised by early embryonic arrest. J Med Genet. 2019 Jul;56(7):471-480.

10.Sang Q*, Li B, Kuang Y, Wang X, Zhang Z, Chen B, Wu L, Lyu Q, Fu Y, Yan Z, Mao X, Xu Y, Mu J, Li Q, Jin L, He L, Wang L*. Homozygous mutations in WEE2 cause fertilization failure and female infertility. Am J Hum Genet. 2018 Apr 5;102(4):649-657.

11.Chen B, Zhang Z, Sun X, Kuang Y, Mao X, Wang X, Yan Z, Li B, Xu Y, Yu M, Fu J, Mu J, Zhou Z, Li Q, Jin L, He L, Sang Q*, Wang L*. Biallelic mutations in PATL2 cause female infertility characterized by oocyte maturation arrest. Am J Hum Genet. 2017 Oct 5;101(4):609-615.

12.Chen B, Li B, Li D, Yan Z, Mao X, Xu Y, Mu J, Li Q, Jin L, He L, Kuang Y, Sang Q*, Wang L*. Novel mutations and structural deletions in TUBB8: expanding mutational and phenotypic spectrum of patients with arrest in oocyte maturation, fertilization or early embryonic development. Hum Reprod. 2017 Feb;32(2):457-464.

13.Feng R#, Sang Q#, Kuang Y#, Sun X#, Yan Z#, Zhang S#, Shi J, Tian G, Luchniak A, Fukuda Y, Li B, Yu M, Chen J, Xu Y, Guo L, Qu R, Wang X, Sun Z, Liu M, Shi H, Wang H, Feng Y, Shao R, Chai R, Li Q, Xing Q, Zhang R, Nogales E, Jin L, He L, Gupta ML Jr, Cowan NJ*, Wang L*. Mutations in TUBB8 and human oocyte meiotic arrest. N Engl J Med. 2016 Jan 21;374(3):223-32.

  

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