全聘课题组长
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  • 张端午

    博士,青年研究员,博士生导师
    地址:徐汇区东安路131号,上海200032
    电话:021-64932808(办公室)
    邮箱:duanwu@fudan.edu.cn

工作经历
青年研究员,复旦大学,生物医学研究院/附属儿科医院(2019.9-今)
Instructor,美国德克萨斯大学西南医学中心(2015.11-2019.8)
博士后,美国德克萨斯大学西南医学中心(2012.9-2015.10)
博士后,厦门大学(2009.10-2012.8)
教育经历
博士,厦门大学/美国Scripps Research Institute联合培养(2005.9-2009.9)
学士,厦门大学,生命科学学院(2001.9-2005.7)
所获奖项

ELSEVIER出版社期刊杰出审稿人奖(2016)
美国德克萨斯大学西南医学中心博士后研究奖(2014)
国家自然科学奖二等奖(第2完成人)(2013)
教育部自然科学奖一等奖(第2完成人)(2010)
全国百篇优秀博士论文奖(2012)
全国卢嘉锡优秀研究生奖(2009)

研究方向
课题组致力于研究免疫信号转导调控及其与疾病发生发展的关系。主要结合免疫学、生物化学、细胞生物学、遗传学、转录组学、代谢组学等方法研究:(1)免疫细胞分化与激活;(2)肿瘤免疫;(3)抗病毒天然免疫;(4)与免疫相关如病原体感染导致的程序性细胞死亡。研究成果将为临床上防治相关疾病(如炎症反应、感染性疾病、癌症等)提供新的参考。
课题组长张端午在其博士和博士后研究阶段,先后师从韩家淮教授(中国科学院院士)和Bruce Beutler教授(诺贝尔奖获得者,美国科学院院士)。迄今发表SCI论文18篇(总影响因子335.8,平均18.7),包括在ScienceNature ImmunologyCell ResearchPNASProtein & CellCellular & Molecular ImmunologyCancer Letters等杂志以第一作者或通讯作者发表系列论文(影响因子之和148.5,平均18.6),论文被引用超过2800次。主持国家自然科学基金委及上海市科委等科研项目。担任Front ImmunolFront Pharmacol等杂志编委,上海市免疫学会感染免疫专业委员会委员。
代表论文

1. Zhang D, Shao J, Lin J, Zhang N, Lu BJ, Lin SC, Dong MQ, Han J (2009). RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science, 325(5938):332-336. (Recommended by F1000Prime)

2. Zhang D, Lin J, Han J (2010). Receptor-interacting protein (RIP) kinase family. Cellular & Molecular Immunology, 7(4):243-249.

3. Han J, Zhong CQ, Zhang D (2011). Programmed necrosis, backup to and competitor with apoptosis in the immune system. Nature Immunology, 12(12):1143-1149.

4. Zhang D#, Zheng M#, Zhao J, Li YY, Huang Z, Li Z, Han J (2011). Multiple death pathways in TNF-treated fibroblasts: RIP3- and RIP1-dependent and independent routes.Cell Research, 21(2):368-371. (# co-first)

5. Lin J, Li H, Yang M, Ren J, Huang Z, Han F, Huang J, Ma J, Zhang D, Zhang Z, Wu J, Huang D, Qiao M, Jin G, Wu Q, Huang Y, Du J, Han J (2013). A role of RIP3-mediated macrophage necrosis in atherosclerosis development. Cell Reports, 3(1):200-210.

6. Wu T, Li Y, Huang D, Han F, Zhang YY, Zhang D*, Han J* (2014). Regulator of G-protein signaling 19 (RGS19) and its partner Gα-inhibiting activity polypeptide 3 (GNAI3) are required for zVAD- induced autophagy and cell death in L929 cells. PLOS One, 9(4):e94634. (*correspondence)

7. Wang T, Zhan X, Bu CH, Lyon S, Pratt D, Hildebrand S, Choi JH, Zhang Z, Zeng M, Wang KW, Turer E, Chen Z, Zhang D, Yue T,..Beutler B (2015). Real-time resolution of point mutations that cause phenovariance in mice. Proc Natl Acad Sci USA, 112(5):E440-E449.

8. Zhang D, Tomisato W, Su L, Sun L, Choi JH, Zhang Z, Wang KW, Zhan X, Choi M, Li X, Tang M, Castro-Perez JM, Hildebrand S, Murray AR, Moresco EMY, Beutler B (2017). Skin-specific regulation of SREBP processing and lipid biosynthesis by glycerol kinase 5. Proc Natl Acad Sci USA, 114(26):E5197-E5206.

9. Choi JH, Wang KW, Zhang D, Zhan X, Wang T, Bu CH, Behrendt CL, Zeng M, Wang Y, Misawa T, Li X, Tang M, Zhan X, Scott L, Hildebrand S, Murray AR, Moresco EM, Hooper LV, Beutler B (2017). IgD class switching is initiated by microbiota and limited to mucosa-associated lymphoid tissue in mice. Proc Natl Acad Sci USA, 114(7):E1196-E1204.

10. Zhang D, Yue T, Choi JH, Nair-Gill E, Zhong X, Wang KW, Zhan X, Li X, Choi M, Tang M, Quan J, Hildebrand S, Moresco EMY, Beutler B (2019). Syndromic immune disorder caused by a viable hypomorphic allele of spliceosome component Snrnp40. Nature Immunology, 20(10):1322-1334.

11. Wang KW, Zhan X, McAlpine W, Zhang Z, Choi JH, Shi H, Misawa T, Yue T, Zhang D, Wang Y, Ludwig S, Russell J, Tang M, Li X, Murray AR, Moresco EMY, Turer EE, Beutler B (2019). Enhanced susceptibility to chemically induced colitis caused by excessive endosomal TLR signaling in LRBA-deficient mice. Proc Natl Acad Sci USA, 116(23):11380-11389.

12. Choi JH, Zhong X, McAlpine W, Liao TC, Zhang D, Fang B, Russell J, Ludwig S, Nair-Gill E, Zhang Z, Wang KW, Misawa T, Zhan X, Choi M, Wang T, Li X, Tang M, Sun Q, Yu L, Murray AR, Moresco EMY, Beutler B (2019). LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling. Science, 364(6440): eaau0812.

13. Yue T, Zhan X, Zhang D, Jain R, Wang KW, Choi JH, Misawa T, Su L, Quan J, Hildebrand S, Xu D, Li X, Turer E, Sun L, Moresco EMY, Beutler B (2021). SLFN2 protection of tRNAs from stress-induced cleavage is essential for T cell-mediated immunity. Science, 372(6543):eaba4220.

14. Wei G, Zhang H, Zhao H, Wang J, Wu N, Li L, Wu J, Zhang D* (2021). Emerging immune checkpoints in the tumor microenvironment: Implications for cancer immunotherapy. Cancer Letters, 511:68-76. (*correspondence)

15. Yang H, Beutler B*, Zhang D* (2021). Emerging roles of spliceosome in cancer and immunity. Protein & Cell, Jul 1. doi: 10.1007/s13238-021-00856-5. (*correspondence)


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