全聘课题组长
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  • 张炜佳

    青年研究员,博士生导师;中山医院合作导师;上海市心血管病研究所及聚合物分子工程国家重点实验室PI

    地址:东安路130号科研二号楼,上海 200032 
    邮箱:weijiazhang@fudan.edu.cn; zhangweijia@fudan.edu.cn

工作经历
教育经历
博士后    哈佛医学院,Harvard—MIT Division of Health Science and Technology,(2014-2016)
博士后    康奈尔医学院,Methodist医院,(2009-2013)
博士      复旦大学,2009
学士      浙江大学,2003
所获人才项目
上海高校特聘教授上海市2015
浦江人才计划 上海市 2015
研究方向

课题组开发及运用新型生物医学技术,探讨大血管病变等疾病的病理生理特征、发生发展机制与干预策略。主持国家级青年人才项目、国家自然科学基金面上基金、上海市基础研究重大项目、科技部重点研发计划课题,参与国家自然科学基金重点项目等项目。
1. 器官芯片微生理系统与组织工程动物模型,应用于动脉疾病等病因研究及药物筛选。
2. 生命分析化学技术与器件,开展针对临床疾病相关小分子、蛋白质等分析。

代表论文

1. Wenrui Ma, Jingjing Zhang, Shaowen Liu, Shiqiang Yan, Kehua Xu, Yu Shrike Zhang, Mieradilijiang Abudupataer, Yang Ming, Shichao Zhu, Bitao Xiang, Xiaonan Zhou, Shaman Luo, Hui Huang, Yuyi Tang, Shan Zhang, Zhuxin Xie, Nan Chen, Xiaoning Sun, Jun Li, Hao Lai, Chunsheng Wang*, Kai Zhu*, Weijia Zhang*, Patient-Derived Microphysiological Model Identifies the Therapeutic Potential of Metformin for Thoracic Aortic Aneurysm. eBiomedicine, 2022, In press.

2. Hui Huang, Youpei Lin, Wenrui Ma, Jiannan Liu, Jing Han, Xiaoyi Hu, Meilin Tang, Shiqiang Yan, Chenping Zhang, Qiang Gao, Weijia Zhang*, A Pre-Screening Strategy to Assess Resected Tumor Margins by Imaging Mitochondrial Viscosity and Hypoxia. eLife, 2021, 10, 70471.

3. Mieradilijiang, A., Zhu, S., Yan, S., Xu, K., Zhang, J., Luo, S., Ma, W., Alam, M. F., Tang, Y., Huang, H., Chen, N., Wang, L., Yan, G., Li, J., Lai, H., Wang, C.*, Zhu, K.*, and Zhang, W.* Aorta smooth muscle-on-a-chip reveals impaired mitochondrial dynamics as a therapeutic target for aortic aneurysm in bicuspid aortic valve disease. eLife, 2021, 10, 69310.

4. Shiqiang Yan, Shuting Wang, Zhujing Hao, Meimei Liu, Chunyue Miao, Md Fazle Alam, Ruihan Bai, Linmei Li, Yong Luo, Tingjiao Liu, Bingcheng Lin, Weijia Zhang*, Yao Lu*. Rapid prototyping of PDMS microdevices via mu PLAT on nonplanar surfaces with flexible hollow-out mask. Biofabrication, 2021, 13, 035001.  

5. Nan Chen, Kai Zhu*, Yu Shrike Zhang, Shiqiang Yan, Tianyi Pan, Mieradilijiang Abudupataer, Guodong Yu, Md Fazle Alam, Li Wang, Xiaoning Sun, Yanlei Yu, Chunsheng Wang*, Weijia Zhang*. Hydrogel Bioink with Multilayered Interfaces Improves Dispersibility of Encapsulated Cells in Extrusion Bioprinting ACS applied materials & interfaces 2019, 11, 30585.

6. Yangyang Zhou#, Weina Fang#, Keqiang Lai, Yongheng Zhu, Xiaojun Bian, Jianlei Shen, Qian Li, Lihua Wang, Weijia Zhang*, Juan Yan*, Terminal deoxynucleotidyl transferase (TdT)-catalyzed homo-nucleotides- constituted ssDNA: Inducing tunable-size nanogap for core-shell plasmonic metal nanostructure and acting as Raman reporters for detection of Escherichia coli O157: H7. Biosensors and Bioelectronics 2019, 141, 111419.

7. Zhang, Q.;  Huang, Y.;  Jiang, B.;  Hu, Y.;  Xie, J.;  Gao, X.;  Jia, B.;  Shen, H.;  Zhang, W.*; Yang, P.* In situ Synthesis of Magnetic Mesoporous PhenolicResin for the Selective Enrichment of Glycopeptides. Analytical Chemistry, 2018, 90, 7357.

8. Zhang Y.S.*, Zhang Y., and Zhang, W.* Cancer-on-a-chip systems at the frontier of nanomedicine. Drug discovery today 2017, 22, 1392-1399.

9. Zhang, W.#, Zhang, Y.S.#, Bakht, S.M.#, Aleman, J., Shin, S.R., Yue, K., Sica, M., Ribas, J., Duchamp, M., Ju, J., Sadeghian, R.B, Kim.,D, Dokmeci, M.R., Atala, A., Khademhosseini, A.*,Elastomeric Free-Form Blood Vessels for Interconnecting Organs on Chip Systems, Lab on a Chip 2016, 16, 1579-1586.  (Cover, Lab on Chip Hot Articles)

10.Zhang, W., Kai, K., Choi, D.S., Iwamoto, T., Nguyen, Y.H., Wong, H., Landis, M.D., Ueno, N.T.*, Chang, J.*, and Qin, L.* Microfluidics Separation Reveals the Stem-Cell–Like Deformability of Tumor-Initiating Cells, Proceedings of the National Academy of Sciences 2012, 109, 18707-18712. (Highlighted by Nature Methods 2013, 10, 14; Lab on Chip, 2013, 13, 599.)

11. Zhang, W., Liu, Y., Cao, R., Li, Z., Zhang, Y., Tang, Y.,* Fan, K. Journal of the American Chemical Society 2008, 130, 15581-15588.

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