课题组致力于利用新技术解析时空多维度钙信号调控系统及钙通道病靶向性药物开发与基因治疗的研究。我们在新型钙探针开发、多维度钙成像、癌症转移调控、心脏兴奋-收缩偶联调控及心肌病（心律失常和心力衰竭等）基因治疗等领域已发表高水平SCI论文二十余篇，包括Nature Biomedical Engineering，Circulation, Nature Communications, Circulation Research等, 撰写英文专著一章，受邀撰写review文章四篇；研究成果共申请专利六项（美国专利二项，一项被美国生物医疗公司Sarepta投资进行临床转化），其中一项专利已获授权。
1.Lu F, Liou C, Ma Q, Wu Z, Xue B, Xia Y, Xia S, Trembley MA, Ponek A, Xie W, Shani K, Bortolin RH, Prondzynski M, Berkson P, Zhang X, Naya FJ, Bedi KC, Margulies KB, Zhang D, Parker KK, Pu WT. Virally delivered CMYA5 enhances the assembly of cardiac dyads. NatureBiomedical Engineering. 2024 Sep 05. (共同通讯)
2.Lu F, Yang P, Zhang D, Wang X, Cheng H. Thirty years of Ca2+ spark research: digital principle of cell signaling unveiled. Biophysics Reports. DOI: 10.52601/bpr.2024.240031. 3.Lu F, Ma Q, Xie W, Liou C, Zhang D, Sweat M, Jardin B, Naya, F, Guo Y, Cheng H, Pu WT. CMYA5 establishes cardiac dyad architecture, positioning, and function.Nature Communications. 2022;13:2185.
4.Lu F,Li Y, Lin S, Cheng H, Yang S. Spatiotemporal regulation of store-operated calcium entry in cancer metastasis. Biochemical Society Transactions. 2021; 49:2581-2589. (共同通讯)
5.Lu F*, Zhao Y*, Xie W, Guo Q, Wang S-Q, Wang X, Cheng H. Imaging sarcoplasmic reticulum Ca2+ signaling in intact cardiac myocytes. Circulation. 2020; 142:1503-1505. (共同通讯，共同一作)
6.Lu F, Pu WT. The architecture and function of cardiac dyads. Biophysical Reviews. 2020; 12:1007-1017.
7.Lu F*, Sun J*, Zheng Q, Li J, Hu Y, Yu P, He H, Zhao Y, Wang X, Yang S. Cheng H. Imaging elemental events of store-operated Ca2+ entry in invading cancer cells with plasmalemmal targeted sensors. Journal of Cell Science. 2019; 132:jcs224923. (共同一作)
8.Lu F, Sun J, Sun T, Cheng H, Yang S. Fluorescence-based measurements of store-operated Ca2+ entry in cancer cells using fluo-4 and confocal live-cell imaging. The CRAC Channel. Springer. 2018; 63-68.
9.Shang W*, Lu F*, Sun T, Xu J, Li LL, Wang Y, Wang G, Chen L, Wang X, Cannell MB, Wang SQ, Cheng H. Imaging Ca2+ nanosparks in heart with a new targeted biosensor. Circulation Research. 2014; 114:412-420. (共同一作)
