杰出青年
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  • 雷群英

    博士,教授,博士生导师
    地址:东安路 131号,明道楼 701室,上海 200032 
    电话:021-54237935 (办公室),021-54237902 (实验室)
    邮箱:qlei@fudan.edu.cn,fudanlqy2014@163.com
    传真:021-54237902
    实验室主页:http://www.cancermetabolism.fudan.edu.cn/

工作经历
教授,复旦大学,肿瘤医院/生物医学研究院,(2017.01~至今)
教授,复旦大学,基础医学院/生物医学研究院,(2009.11~2016.12)
副教授,复旦大学,基础医学院/生物医学研究院,(2006.03~2009.10)
博士后,加州大学洛杉矶分校,分子药理学系,(2002.09~2006.01)
预防医师,江西进贤疾控中心,(1993.07-1996.08)
教育经历
博士,复旦大学上海医学院,生物化学与分子生物学系,(1999.09~2002.07)
硕士,苏州大学苏州医学院,生物化学与分子生物学系,(1996.09~1999.07)
学士,南昌大学江西医学院,预防医学,(1988.09-1993.07)
所获人才项目
万人计划,科技部,2016
长江学者特聘教授,教育部,2015
中青年科技创新领军人才,科技部,2014
上海市优秀学术带头人,上海市科委,2013
国家杰出青年科学基金,国家自然科学基金,2012
曙光学者,上海市教委,2011
上海市卫生系统优秀学术带头人,上海市卫计委,2011
新世纪优秀人才,教育部,2009
浦江人才计划 ,上海市科委,2007
所获奖项
上海市自然科学一等奖,上海市科委,2019
全国三八红旗手,全国妇联,2017
上海市三八红旗手标兵,上海市妇联,2016
上海市自然科学牡丹奖,上海市科协,2015
五洲女子科技奖,中国女医师协会,2015
自然科学二等奖,教育部,2014
中国青年女科学家奖,联合教科文组织,2013
自然科学一等奖,教育部,2012
上海市三八红旗手,上海市妇联,2012
明治生命科学奖(杰出奖),国家人类基因组南方研究中心,2011
研究方向
代谢异常是癌症的一个重要标志。癌细胞即使在不缺氧的状态下也优先利用葡萄糖产生乳酸,这就是著名的瓦伯格效应(Warburg效应)。最近的癌症基因组学研究发现癌症的发生和发展与代谢异常有直接关系。目前一个涵盖癌症细胞内外的异常代谢特征网络正在形成, 而这些代谢特征是如何在肿瘤发生过程中形成且如何改变代谢进而导致癌症发生发展的机制还有很多尚未研究清楚。
课题组通过探索癌细胞对不同营养物质的感受利用, 确定导致肿瘤细胞代谢改变的关键酶,并研究其在肿瘤微环境中的新陈代谢功能等等,希望能够阐明癌症发生和发展过程中潜在的代谢机制变化。
课题组长雷群英主持多项国家和省部级项目,包括国家重点研发计划(项目首席)、国家自然科学基金重大项目、重点项目和上海市教委重点项目等。迄今为止,已在国内外学术刊物上发表论文近60余篇,包括Cancer cell,Cell Metabolism, Molecular Cell,Nature Cell Biology, Nature Communications 和 J.Clin. Invest.等。
代表论文

1.Li JT#, Yin M#, Wang D#, Wang J, Lei MZ, Zhang Y, Liu Y, Zhang L, Zou SW, Hu LP, Zhang ZG, Wang YP, Wen WY, Lu HJ, Chen ZJ, Su D, Lei QY*.  BCAT2-mediated BCAA catabolism is critical for development of pancreatic ductal adenocarcinoma. Nature Cell Biology.202022: 161-174. doi.org/10.1038/ s41556-019-0455-6

Highlights Preview in Nature Cell Biology

2.Liu Y#, Guo JZ#, Liu Y#, Wang K, Ding WC, Wang H, Liu X, Zhou ST, Lu XC, Yang HB, Xu CY, Gao W, Zhou L, Wang YP, Hu WG, Wei YQ,  Huang CH*, Lei QY*Nuclear Lactate Dehydrogenase A Senses ROS to Produce a-Hydroxybutyrate for HPV-Induced Cervical Tumor GrowthNature Commun. 2018; 9: 4429.  doi: 10.1038/s41467-018-06841-724

3. Zhong XY, Yuan XM, Xu YY, Yin M, Yan WW, Zou SW, Wei LM, Lu HJ, Wang YP*, Lei QY*.CARM1 Methylates GAPDH to Regulate Glucose Metabolism and Is Suppressed in Liver Cancer. Cell Rep. 2018; 24(12):3207-3223. doi: 10.1016/j.celrep.2018.08.066.

4.Xia S, Lin R, Jin L, Zhao L, Kang HB, Pan Y, Liu S, Qian G, Qian Z, Konstantakou E, Zhang B, Dong JT, Chung YR, Abdel-Wahab O, Merghoub T, Zhou L, Kudchadkar RR, Lawson DH, Khoury HJ, Khuri FR, Boise LH, Lonial S, Lee BH, Pollack BP, Arbiser JL, Fan J* Lei QY*, Chen J*. Prevention of Dietary-Fat-Fueled Ketogenesis Attenuates BRAF V600E Tumor Growth. Cell Metabolism. 2017, 25(2):358-373

Highlights Nature

5.Zhang Y#, Xu YY#, Zhao XN, Li JT, Yang HB, Zhang M, Li, Yao CB, Yin M*, Chen J*, Lei QY*. (2016). Acetylation targets HSD17B4 for degradation via CMA pathway in response to E1. Autophagy. 2017, 13(3):538-553.

6.Wang YP*Wang JGao X, Xu YY, Cheng JK*, Lei QY*. Arginine Methylation of MDH1 by CARM1 Inhibits Non-canonical Glutamine Metabolism and Suppresses Pancreatic Cancer. Molecular Cell. 201664, 673–687

Highlights Cancer discovery

7.Gao X#, Lin SH#Ren F, Li1 JT, Chen JJ, Yao CB,Yang HB,Jiang SX, Yan GQ, Wang D Wang Y, Liu Y, Cai Z, Xu YY, Chen J, Yu W, Yang YP*, Lei QY*. Acetate Functions as an Epigenetic Metabolite to Promote Lipid Synthesis under Hypoxia. Nature Commun. 2016 Jun 30;7:11960. doi: 10.1038/ncomms11960

8.Yang, HB#., Xu, YY#*., Zhao, XN, Zou SW*., Zhang Y., Zhang M., Li JT, Ren F., Wang LY., Lei QY*. Acetylation of MAT IIα represses tumour cell growth and is decreased in human hepatocellularcancer. Nature Commun. 2015Apr 30;6:6973. doi: 10.1038/ncomms7973.

9.Zha, ZY., Han, XR., Matthew D. Smith, Liu, Y., Patrick M. Giguère, DraganaKopanja, PradipRaychaudhuri, David P. Siderovski, Guan, KL*., Lei, QY. *, and Xiong, Y*. A non- canonical function of Gβ as a subunit of E3 ligase in targeting GRK2 ubiquitylation. Molecular Cell. 201558(5):794-803

10.Zhou, X#., Wang, SY#., Wang, Z., Feng, X., Liu, P., Lv, X-B., Li, F-L., Yu, F-x., Sun,YP., Yuan, HX., Zhu, HG., Xiong,Y*., Lei, QY*., Guan, KL*. Estrogen Activates TAZ via GPER in Invasive Ductal Breast Carcinoma. J Clin Invest. 2015125(5):2123-35

11.Zhao, D., Mo, Y., Li, MT., Zou,SW., Cheng, ZL., Sun, Y-P., Xiong, Y*., Guan, KL*., Lei, QY*.NOTCH-induced aldehyde dehydrogenase 1A1 deacetylation promotes breast cancer stem cells. J Clin Invest. 2014124(12):5453-65

12.Li T, Liu F, Feng X, Wang Z, Das I, Xu Y, Zhou X, Sun Y, Guan KL, Xiong Y, Lei QY*. Glyceraldehyde-3-phosphate Dehydrogenase Is Activated by Lysine 254 Acetylation in Response to Glucose Signal. J. Biol. Chem. 2014289(6):3775-85

13.Lv L#, Xu Y#, Zhao D, Li F, Wang W, Sasaki N, Jiang Y, Zhou X, Li T, Guan KL*, Lei QY* and Xiong Y*. Mitogenic and oncogenic stimulation of K433 acetylation promote PKM2 protein kinase activity and nuclear localization. Molecular Cell. 201352, 340–352

HighlightsCover story in Molecular cell, Highlight by Nature Review in Cancer and Cancer discovery

14.Lin R#, Ren T#, Gao X, Zhou X, Li T, Xiong Y, Guan KL, Lei QY*. Acetylation Stabilizes ATP- citrate Lyase to Promote Lipid Biosynthesis and Tumor Growth. Molecular Cell. 201351, 506–518

15.Zhao D#, Zou S#, Liu Y, Zhou X, Mo Y, Wang P, Xu Y, Dong B, Xiong Y*, Lei QY* and Guan KL*., Lysine-5 Acetylation Negatively Regulates Lactate Dehydrogenase A and Is Decreased in Pancreatic Cancer. Cancer Cell. 201323, 464-476

16.Lv L, Li D, Zhao D, Lin R, Chu YZhang H, Zha Z, Ying Liu, Li Z, Xu Y, Huang Y, Gang W, Xiong Y, Guan KL, and Lei QY*. Acetylation Targets the M2 Isoform of Pyruvate Kinase for Degradation through Chaperone-Mediated Autophagy and Promotes Tumor Growth. Molecular Cell. 201142, 719-730

HighlightsFeature article Preview in Molecular Cell, highlighs in Science Signaling, Faculty of 1000

Invited Review

Li JT, Wang YP, Yin M*, Lei QY*. (2019). Metabolism remodeling in pancreatic ductal adenocarcinoma. Cell Stress; 3(12):361-368.

Wang YP*, Lei QY*. (2018). Metabolite sensing and signaling in cell metabolism. Signal Transduction and Targeted Therapy; 3:30.

Zhou X, Lei QY*. (2016). Regulation of TAZ in cancer. Protein Cell; 7(8):548-61.

Zhou X, Wang Z, Huang W, Lei QY*. (2015). G protein-coupled receptors: bridging the gap from the extracellular signals to the Hippo pathway. Acta Biochim Biophys Sin (Shanghai); (1):10-5.

Huang W, Wang Z, Lei QY*. (2014). Acetylation control of metabolic enzymes in cancer: an updated version. Acta Biochim Biophys Sin (Shanghai); 46(3):204-13.

Lin R, Zhou X, Huang W, Zhao D, Lv L, Xiong Y, Guan KL, Lei QY*. (2014). Acetylation control of cancer cell metabolism. Curr Pharm Des; (15):2627-33.

Zhao D, Li FL, Cheng ZL, Lei QY*. (2014). Impact of acetylation on tumor metabolism. Mol Cell Oncol. ; 1(3):e963452. 


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