双聘课题组长
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  • 舒易来

    博士,主任医师、研究员,博士生导师
    地址:上海市医学院路138号生物医学研究院,上海 200032 
    电话:021-64377134
    邮箱:yilai_shu@fudan.edu.cn

工作经历
主任医师,复旦大学附属眼耳鼻喉科医院(2022.12-至今)
研究员,复旦大学附属眼耳鼻喉科医院(2018.12-至今)
副主任医师,复旦大学附属眼耳鼻喉科医院(2017.11-2022.12)
主治医师,复旦大学附属眼耳鼻喉医院(2014.08-2017.11)
博士后,哈佛大学医学院(2012.07-2014.07)
教育经历
联合培养博士,哈佛大学医学院,麻省眼耳鼻喉科医院(2010.10-2012.06)
硕博连读,复旦大学,附属眼耳鼻喉科医院(2007.09-2012.06)
学士,南华大学,临床医学系(1999.09-2004.06)
所获人才项目
国家杰出青年科学基金,2022
上海市卫健委“医苑新星”杰出青年,2021
上海市曙光学者,2020
复旦大学“卓越2025”卓识人才,2019
国家优秀青年科学基金,2018
上海市浦江人才,2015
所获奖项
“一健康基金”优秀教师一等奖,2023
上海医学科技奖二等奖,2022
上海市青年五四奖章,2020
上海市银蛇奖,2019
复旦大学附属眼耳鼻喉科医院“汾阳杰青奖”,2018
美国耳鼻咽喉头颈外科研究年会优秀医师,2015、2017
研究方向
据世界卫生组织和柳叶刀杂志报道,超过全世界人口的20%,也就是15.7亿人有听力损失,听力残疾占我国残疾总人口的24%。课题组围绕听觉医学开展如下工作:1)基于CRISPR/Cas9基因编辑或基因补偿的遗传性耳聋基因治疗及临床转化;2)内耳毛细胞再生和听觉保护。发表SCI文章82篇,其中第一/通讯作者58篇(影响因子10以上的文章20篇,单篇最高影响因子96),包括BMJ、Science Translational Medicine、Neuron、Cell Research、Molecular Therapy、Nature Communications、Genome Biology、Signal Transduction and Targeted Therapy、Autophagy、Cell Discovery、Human Gene Therapy(封面导读)等著名期刊。取得了一系列创新性的结果,包括:与国际著名基因编辑专家David Liu、著名听觉领域专家Zheng-Yi Chen教授合作,首次以CRISPR/Cas9对活体听觉细胞进行基因编辑,发表在Nature Biotechnology;阐释了GJB2、SLC26A4、KCNQ4、MYO6 致聋基因的发病机制;开发了基因治疗药物导入内耳的新路径和新载体;以 MYO6、KCNQ4、TMC1、OTOF、Klhl18 等遗传性耳聋基因为靶点,研发了DNA敲除、同源重组、RNA编辑、基因置换等遗传性耳聋治疗新策略;开辟防治后天感音神经性耳聋新方向;研发出我国首款OTOF突变耳聋的基因治疗候选药物,并完成全球首例遗传性耳聋患者的给药;发现了成年哺乳动物内耳支持细胞和毛细胞重编程增殖再生。主持包括科技部重点研发课题、国自然杰青、优青、面上、青年、上海市教委重大、上海市科委政府间合作(芬兰)、上海浦江人才、上海市科委自然科学探索类、上海市科委创新行动计划、上海市曙光学者、上海市申康临床研究项目、上海市卫健委杰青等15项纵向课题。近5年6次在权威国际大会发言。2015-2018年担任美国耳鼻咽喉头颈外科研究协会(ARO)国际委员会委员(中国代表),2018-2021年任美国ARO执行委员会委员(亚洲代表)。现任中华医学会耳鼻咽喉头颈外科分会委员、上海市医学会耳鼻咽喉头颈外科分会青委、中国生物物理学会听觉、言语和交流研究分会常委。
代表论文

1.Cheng X.; Peng K.; Chen B.; Shu Y*. A teenager with auricular infection secondary to piercing.BMJ. 2023 Mar 16;380:e071715.

2.Li Q.#*; Cui C.#; Liao R.; Yin X.; Wang D.; Cheng Y.; Huang B.; Wang L.; Yan M.; Zhou J.; Zhao J.; Tang W.; Wang Y.; Wang X.; Lv J.; Li J.; Li H.*; Shu Y.*. The pathogenesis of common Gjb2 mutations associated with human hereditary deafness in mice. Cell Mol Life Sci. 2023 May 13;80(6):148.

3.Liu Q#, Zhang X#, Huang H#, Chen Y#, Wang F, Hao A, Zhan W, Mao Q, Hu Y, Han L, Sun Y, Zhang M, Liu ZZhang WShu Y*, Sun L*, Chen Z*. Asymmetric Pendrin Homodimer Reveals its Molecular Mechanism as Anion Exchanger. Nat Commun. 2023. (Accepted)

4.Jiang L.#; Wang D.#; He Y.*; Shu Y.*. Advances in gene therapy hold promise for treating hereditary hearing loss. Mol Ther. 2023 Apr 5;31(4):934-950.

5.Tang H.#; Wang H.#; Wang S.#; Hu SW.#; Lv J.; Xun M.; Gao K.; Wang F.; Chen Y.; Wang D.; Wang W.*; Li H.*; Shu Y.*. Hearing of Otof-deficient mice restored by trans-splicing of N- and C-terminal otoferlin. Hum Genet. 2023 Feb;142(2):289-304.

6.Xiao, Q.#;Xu, Z.#;Xue, Y.#;Xu, C.#;Han, L.;Liu, Y.;Zhang, P.;Wang, F.;Zhang, R.; Han, S.;Wang, X.;Li, G. L.; Li, H*.; Yang, H*.; Shu, Y*., Rescue of autosomal dominant hearing loss by in vivo delivery of mini dCas13X-derived RNA base editor. Science Translational Medicine, 2022 Jul 20;14(654):eabn0449.

7.Gu, X.#;Hu, X.#;Wang, D.#;Xu, Z.;Wang, F.;Li, D.;Li, G. L.;Yang, H.;Li, H*.;Zuo, E*.; Shu, Y*., Treatment of autosomal recessive hearing loss via in vivo CRISPR/Cas9-mediated optimized homology-directed repair in mice. Cell Res,2022 Jul;32(7):699-702

8.Zheng, Y.#;Liu, H.#;Chen, Y.#;Dong, S.#;Wang, F.;Wang, S.;Li, G. L.;Shu, Y*.; Xu, F. *, Structural insights into the lipid and ligand regulation of a human neuronal KCNQ channel. Neuron2022,110 (2), 237-247.e4.

9.Zheng, Z.#;Li, G.#;Cui, C.#;Wang, F.;Wang, X.;Xu, Z.;Guo, H.; Chen, Y.;Tang, H.;Wang, D.;Huang, M.;Chen, Z. Y.;Huang, X.;Li, H.;Li, G. L.*;Hu, X.*; Shu, Y.*, Preventing autosomal-dominant hearing loss in Bth mice with CRISPR/CasRx-based RNA editing. Signal Transduct Target Ther2022,7 (1), 79.

10.Xue Y.#; Hu X.#; Wang D.#; Li D.#; Li Y.; Wang F.; Huang M.; Gu X.; Xu Z.; Zhou J.; Wang J.; Chai R.; Shen J.; Chen ZY.; Li GL.; Yang H.; Li H.*; Zuo E.*; Shu Y.*. Gene editing in a Myo6 semi-dominant mouse model rescues auditory function. Mol Ther. 2022 Jan 5;30(1):105-118.

11.Gu, X.#;Wang, D.#;Xu, Z.#;Wang, J.;Guo, L.;Chai, R.;Li, G.;Shu, Y.*; Li, H.*, Prevention of acquired sensorineural hearing loss in mice by in vivo Htra2 gene editing. Genome Biol2021,22 (1), 86.

12.Cui C.#; Wang D.#; Huang B.#; Wang F.#; Chen Y.; Lv J.; Zhang L.; Han L.; Liu D.; Chen ZY.; Li GL.; Li H.; Shu Y*. Precise detection of CRISPR-Cas9 editing in hair cells in the treatment of autosomal dominant hearing loss, Mol Ther Nucleic Acids, 2022 Jul 20;29:400-412.

13.Wang J.; Wang C.; Wang Q.; Zhang Z.; Wang H.; Wang S.; Chi Z.; Shang L.*; Wang W.*; Shu Y.* Microfluidic Preparation of Gelatin Methacryloyl Microgels as Local Drug Delivery Vehicles for Hearing Loss Therapy. ACS Appl Mater Interfaces. 2022 Oct 19;14(41):46212-46223.

14.Tang H.; Wang D.; Shu Y*.Structural insights into Cas9 mismatch: promising for development of high-fidelity Cas9 variants. Signal Transduct Target Ther. 2022 Aug 4;7(1):271.

15.Guo, Y.#;Han, L.#;Han, S.;Tang, H.;Wang, S.;Cui, C.;Chen, B.*;Li, H.*; Shu, Y.*, Specific knockdown of Htra2 by CRISPR-CasRx prevents acquired sensorineural hearing loss in mice. Mol Ther Nucleic Acids2022,28, 643-655.

16.Wang, J.;Zhao, L.;Gu, X.;Xue, Y.;Wang, S.;Xiao, R.;Vandenberghe, L.;Peng, K. A.;Shu, Y*.; Li, H*., Efficient delivery of adeno-associated virus (AAV) into inner ear in vivo via trans-stapes route in adult guinea pig. Human Gene Therapy,2022 Jul;33(13-14):719-728. (Cover story

17.Zhang K.#; Cheng X.#; Zhao L.#; Huang M.; Tao Y.; Zhang H.; Rosenholm JM.; Zhuang M.; Chen ZY.; Chen B.*; Shu Y*. Direct Functional Protein Delivery with a Peptide into Neonatal and Adult Mammalian Inner Ear In Vivo. Mol Ther Methods Clin Dev. 2020 Jun 30;18:511-519.

18.Bing Wang; Tianwen Xin, Lang Shen, Kun Zhang, Dan Zhang, Hui Zhang, Jisheng Liu, Bing Chen*,Wenguo Cui*, Yilai Shu*. Acoustic transmitted electrospun fibrous membranes for tympanic membrane regeneration. Chemical Engineering Journal,27 March 2021,129536.

19.Yilai Shu#, Wenyan Li#, Mingqian Huang#, Yi-Zhou Quan#, Yong Tao, Xuezhong Liu, Konrad Hochedlinger, Zhengmin Wang, Huawei Li and Zheng-Yi Chen. Renewed proliferation in adult mouse cochlea and regeneration of hair cells, Nature communications. 2019 Dec 4;10(1):5530.

20.Cheng, X.;Liu, J.;Li, N.;Nisenbaum, E.;Sun, Q.;Chen, B.;Casiano, R.;Weed, D.;Telischi, F.;Denneny, J. C., 3rd;Liu, X. *; Shu, Y*., Otolaryngology Providers Must Be Alert for Patients with Mild and Asymptomatic COVID-19. Otolaryngol Head Neck Surg 2020, 162 (6), 809-810.

21.Zhang, K.; Fang, Y.; Wang, B.; Cheng, X.; Chen, B. *; Shu, Y*, Frequency-specific hearing results after stapes surgery for Chinese population otosclerosis with different degrees of hearing loss. Acta Otolaryngol2020, 140 (5), 356-360.

22.Wenwei Luo, Jingfang Wu, Kevin A. Peng , Qingzhong Li, Qiang Du,Jianghong Xu, Chunfu Dai, Fanglu Chi*, Yilai Shu*Clinical characteristics of patients with papilloma in the external auditory canalLaryngoscope27-Aug-2020 2020 Oct 8. doi: 10.1002/lary.29113

23.Yilai Shu#, Lijun Wang#, Xiaoting Cheng, Chayada Tangshewinsirikul, Weili Shi, Yasheng Yuan, Zhiqiang Yang, Huawei Li, Jun Shen*, Bing Chen*, Weiguo Zou* The p.Pro170Leu Variant in NOG Impairs Noggin Secretion and Causes Autosomal Dominant Congenital Conductive Hearing Loss Due to Stapes Ankylosis, Journal of Genetics and Genomics, 2019 Sep 20;46(9):445-449.

24.Jinghan Wang#, Jun Shen#, Luo Guo, Cheng Cheng, Renjie Chai, Yilai Shu* Huawei Li*. A humanized mouse model demonstrated that apparently autosomal dominant deafness caused by MYO6 p.C442Y is inherited in a semi-dominant pattern. Hearing research, 2019 Aug;379:79-88.

25.Zuris JA, Thompson DB, Shu Y, Guilinger JP, Bessen JL, Hu JH, Maeder ML, Joung JK, Chen ZY, Liu DR*. Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo. Nature Biotechnology. 2015 Jan;33(1):73-80.

26.Xiaoting Cheng#, Yanqing Fang, Yilai Shu*, Duo-Duo Tao, Yangwenyi Liu, Bing Wang, Yasheng Yuan, John J. Galvin, Qian-Jie Fu, Bing Chen* Music training can improve music and speech perception in pediatric Mandarin-speaking cochlear implant users. Trends in Hearing2018 9:2331216518759214,

27.Gao X, Tao Y, Lamas V, Huang M, Yeh WH, Pan B, Hu YJ, Hu JH, Thompson DB, Shu Y, Li Y, Wang H, Yang S, Xu Q, Polley DB, Liberman MC, Kong WJ, Holt JR, Chen ZY*, Liu DR*. Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents. Nature. 2018 Jan 11;553(7687):217-221.

28.Shu Y#, Tao Y, Wang Z, Tang Y, Li H, Dai P, Gao G, Chen ZY*. Identification of Adeno-associated viral vectors (AAV) that target neonatal and adult mammalian inner ear cell subtypes. Human Gene Therapy. 27(9):687-99.2016 Jun 24. (Cover story)


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