博士,青年研究员
地址:上海市东安路131号,200032
邮箱:chen_haiwei@fudan.edu.cn
1.Chen H, Rosen CE, Gonzalez-Hernandez JA, Ring AM, Palm NW. Highly multiplexed bioactivity screening reveals human and microbiota metabolome-GPCRome interactions. Cell (under revision)
2.Yang Y, Nguyen M, Khetrapal V, Sonnert ND, Martin AL, Chen H, Martin AK, Palm NW. Within-host evolution of a gut pathobiont facilitates liver translocation. Nature 607, 563-570 (2022)
3.Kim CS, Gatsios A, Guesta S, Lam YC, Wei Z, Chen H, Russell RM, Shine EE, Wang R, Wyche TP, Piizzi G, Flavell RA, Palm NW, Sperandio V, Crawford JM. Characterization of autoinducer-3 structure and biosynthesis in E.Coli. ACS Cent. Sci. 2020, 6, 197-206
4.OhJ,KinNY,ChenH,PalmNW,CrawfordJM.AnUgi-likebiosynthetic pathway encodes bombesinreceptorsubtype-3agonists.J.Am.Chem.Soc. 2019,141,41, 16271-16278
5.ChenH,NwePK,YangY,RosenCE,BieleckaAA,KuchrooM,ClineGW, Kruse AC, RingAM,CrawfordJM,PalmNW.Aforwardchemicalgeneticscreen reveals gut microbiota metabolitesthatmodulatehostphysiology.Cell.2019May16; 177(5): 1217-1231. e18.
6.ZhuS,DingS, WangP,WeiZ,PanW,PalmNW,YangY,YuH,LiHB, Wang G, Lei X, deZoeteMR,ZhaoJ,ZhengY,ChenH,ZhaoY,JuradoKA,FengN,ShanL, Kluger Y, LuJ,AbrahamC,FikrigE,GreenbergHB,FlavellRA. Nlrp9b inflammasome restricts rotavirusinfectioninintestinalepithelialcells. Nature.2017Jun29; 546(7660):667-670
7.Li M, DiW,XuH,YangY,ChenH,ZhangF,ZhaiZ,ChenD.Negativeregulation of RIG-I-mediated innate antiviral signaling by SEC14L1. J Virol. 87(18): 10037-46. PMID: 23843640
8.YangZ,LiangH,ZhouQ,LiY,ChenH,YeW,ChenD,FlemingJ,ShuH,LiuY.CrystalstructureofISG54revealsanovelRNAbindingstructureandpotentialfunctionalmechanisms.CellRes.22:1328-38.PMID:22825553.
9.YangY,QuH,GaoD,DiW,ChenH,GuoX,ZhaiZ,ChenD.ARF-likeprotein16(ARL16)inhibitsRIG-IbybindingwithitsC-terminaldomaininaGTP-dependentmanner.JBiolChem;286(12):10568-80.PMID:21233210.
10.Chen H, Yang Y, Xu H, Yang W, Zhai Z, Chen DY. Ring finger protein 166 potentiates RNA virus-induced interferon- production via enhancing the ubiquitination of TRAF3 and TRAF6. Scientific Reports 5, 14770. PMID: 26456228.