全聘课题组长
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  • 王罡琦

    博士,青年研究员
    地址:东安路 131号,上海 200032
    邮箱:wanggangqi@fudan.edu.cn

工作经历
青年研究员,复旦大学,生物医学研究院(2024.05-至今)
博士后,荷兰莱顿大学医学中心 (2020.09-2024.05)
教育经历
博士,荷兰莱顿大学 (2014.10-2020.9)
硕士,吉林大学 (2011.09-2014.06)
本科,哈尔滨工业大学 (2007.09-2011.06)
所获人才项目
所获奖项
莱顿大学医学中心年度最佳论文 2022
研究方向
课题组致力于空间代谢组学及空间多组学技术开发,聚焦细胞代谢在肾脏发育和损伤修复中的调控机制,并开展遗传性肾脏疾病的基础研究。主要研究成果包括:首创空间定量代谢组学和单细胞水平空间动态代谢组学检测技术;揭示肾脏发育中细胞代谢变化轨迹,并应用于类器官培养以促进其分化成熟;构建肾脏体外灌注系统,首次实现人肾脏体外存活4-8天。已发表SCI论文20余篇,其中以第一/通讯作者在Cell Stem Cell、Nature Metabolism(2022, 2025)、Nature Communications、JASN等期刊发表论文10篇。受邀基于自身研究成果在Nature Reviews Nephrology(2017,2024a,2024b)参与撰写综述3篇。
代表论文

1.Wang, G., van den Berg, B. M., Kostidis, S., Pinkham, K., Jacobs, M. E., Liesz, A., ... & Rabelink, T. J. (2024). Spatial quantitative metabolomics enables identification of remote and sustained ipsilateral cortical metabolic reprogramming after stroke. Nature Metabolism, 2025. (已接收,第一兼共同通讯作者)

2.Rabelink, T. J., Wang, G., van der Vlag, J., & van den Berg, B. M. (2024). The roles of hyaluronan in kidney development, physiology and disease. Nature Reviews Nephrology, 20(12), 822-832.

3.Tasca, P., van den Berg, B. M., Rabelink, T. J., Wang, G., Heijs, B., van Kooten, C., ... & Kers, J. (2024). Application of spatial-omics to the classification of kidney biopsy samples in transplantation. Nature Reviews Nephrology, 20(11), 755-766.

4.de Haan, M. J., Jacobs, M. E., Witjas, F. M., de Graaf, A. M., Sánchez-López, E., Kostidis, S., ... Wang, G.*, Engelse, M. A.*, Rabelink, T. J*. (2024). A cell-free nutrient-supplemented perfusate allows four-day ex vivo metabolic preservation of human kidneys. Nature Communications, 15(1), 3818. (*共同通讯作者)

5.Wang, G., Heijs, B., Kostidis, S., Rietjens, R. G., Koning, M., Yuan, L., ... & Rabelink, T. J. (2022). Spatial dynamic metabolomics identifies metabolic cell fate trajectories in human kidney differentiation. Cell Stem Cell, 29(11), 1580-1593.

6.Wang, G., Heijs, B., Kostidis, S., Mahfouz, A., Rietjens, R. G., Bijkerk, R., ... & Rabelink, T. J. (2022). Analyzing cell-type-specific dynamics of metabolism in kidney repair. Nature Metabolism, 4(9), 1109-1118.

7.Wang, G., Kostidis, S., Tiemeier, G. L., Sol, W. M., de Vries, M. R., Giera, M., ... & Rabelink, T. J. (2020). Shear stress regulation of endothelial glycocalyx structure is determined by glucobiosynthesis. Arteriosclerosis, thrombosis, and vascular biology, 40(2), 350-364.

8.Wang, G., Tiemeier, G. L., van den Berg, B. M., & Rabelink, T. J. (2020). Endothelial glycocalyx hyaluronan: regulation and role in prevention of diabetic complications. The American journal of pathology, 190(4), 781-790.

9.Van Den Berg, B. M.*, Wang, G.*, Boels, M. G., Avramut, M. C., Jansen, E., Sol, W. M., ... & Rabelink, T. J. (2019). Glomerular function and structural integrity depend on hyaluronan synthesis by glomerular endothelium. Journal of the American Society of Nephrology, 30(10), 1886-1897.(共同第一作者)

10.Rabelink, T. J., Van Den Berg, B. M., Garsen, M., Wang, G., Elkin, M., & Van Der Vlag, J. (2017). Heparanase: roles in cell survival, extracellular matrix remodelling and the development of kidney disease. Nature Reviews Nephrology, 13(4), 201-212.


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