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  • 张琰青

    博士,青年研究员
    地址:上海市东安路131号科研二号楼
    邮箱:zyq_lab@fudan.edu.cn

工作经历
青年研究员,复旦大学,生物医学研究院/附属上海市第五人民医院双聘PI(2021-至今)
副研究员,西湖大学,生命科学学院(2019-2021)
访问学者,美国匹兹堡大学医学院(2017)
博士后,清华大学,生命科学学院(2015-2019)
教育经历
博士,清华大学,生命科学学院(2010-2015)
学士,山东大学,生命科学学院(2006-2010)
所获人才项目
上海市青年科技启明星计划项目(2021) 
所获奖项
北京市优秀毕业生(2016)
研究方向
1. 综合利用冷冻电镜技术、分子动力学模拟和功能实验,研究膜转运蛋白的结构和功能。2. 运用冷冻电子断层技术(cryo-ET),研究细胞或组织冷冻电镜原位生物大分子的结构与功能。
招生专业
生物化学与分子生物学
代表论文

2021-:

1. Feiwen Wei, Huihui Liu, Wei Zhang, Jufang Wang, Yanqing Zhang*. (2024). Drug inhibition and substrate alternating flipping mechanisms of human VMAT2. bioRxiv. doi: https://doi.org/10.1101/2024.02.28.582500

2. Ziyang Shan, Xuemei Yang, Huihui Liu, Yafei Yuan, Yuan Xiao, Jing Nan, Wei Zhang, Wenqi Song, Jufang Wang, Feiwen Wei, Yanqing Zhang*. (2023). Cryo-EM structures of human organic anion transporting polypeptide OATP1B1. Cell Research. 33(12): 940-951 (*: corresponding)

3. Jing Nan, Yafei Yuan, Xuemei Yang, Ziyang Shan, Huihui Liu, Feiwen Wei, Wei Zhang, Yanqing Zhang*. (2022). Cryo-EM structure of the human sodium-chloride cotransporter NCCScience Advances. 8, eadd7176. (*: corresponding)

4. Jinghua Xu, Jiuqing Wang, Aijun Liu, Yanqing Zhang*, Xiang Gao*. (2021). Structural and functional analysis of SsaV cytoplasmic domain and variable linker states in the context of the InvA-SsaV chimeric protein. Microbiology Spectrum. 9, e0125121. (*: corresponding)

2015-2020:

5. Yanqing Zhang#, Sai Li#, Chao Zeng#, Gaoxingyu Huang#, Xuechen Zhu#, Qifan Wang, Kunpeng Wang, Qiang Zhou, Chuangye Yan, Wusheng Zhang, Guangwen Yang, Minhao Liu, Qinghua Tao, Jianlin Lei, Yigong Shi*. (2020). Molecular architecture of the luminal ring of the Xenopus laevis nuclear pore complex. Cell Research. 30, 532-540. 

Featured on the COVER; F1000Prime Recommendation

6. Gaoxingyu Huang#Yanqing Zhang#, Xuechen Zhu#, Chao Zeng#, Qifan Wang, Qiang Zhou, Qinghua Tao, Minhao Liu, Jianlin Lei, Chuangye Yan, Yigong Shi*. (2020). Structure of the cytoplasmic ring of the Xenopus laevis nuclear pore complex by cryo-electron microscopy single particle analysis. Cell Research. 30, 520-531.

7. Qiang Su#, Feizhuo Hu#, Yuxia Liu#, Xiaofei Ge, Changlin Mei, Shengqiang Yu, Aiwen Shen, Qiang Zhou, Chuangye Yan, Jianlin Lei, Yanqing Zhang*, Xiaodong Liu* & Tingliang Wang*. (2018). Cryo-EM structure of the polycystic kidney disease-like channel PKD2L1. Nature Communications. 9, 1192. (*: corresponding)

8. Yanqing Zhang#, Zhengtao Xiao#, Qin Zou, Jianhuo Fang, Qifan Wang, Xuerui Yang*, Ning Gao*. (2017). Ribosome profiling reveals genome-wide cellular translational regulation upon heat stress in Escherichia coli. Genomics Proteomics & Bioinformatics. 15, 324-330.

9. Yanqing Zhang, Chandra Sekhar Mandava, Wei Cao, Xiaojing Li, Dejiu Zhang, Ningning Li, Yixiao Zhang, Xiaoxiao Zhang, Yan Qin, Kaixia Mi, Jianlin Lei*, Suparna Sanyal*, Ning Gao*. (2015). HflX is a ribosome-splitting factor rescuing stalled ribosomes under stress conditions. Nature Structural & Molecular Biology. 22, 906-913.

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