运用冷冻电子断层技术和冷冻电镜单颗粒技术，研究以核孔复合物为代表的细胞原位跨尺度生物大分子的结构与功能。主要研究成果包括，首次发现核孔复合物腔环精细结构；将核孔复合物胞质环结构从20埃首次提高至近原子分辨率，实现了分辨率的重大突破。

代表论文

1. Jing Nan^#, Yafei Yuan^#, Xuemei Yang^#, Ziyang Shan^#, Huihui Liu, Feiwen Wei, Wei Zhang, Yanqing Zhang*. (2022). Cryo-EM structure of the human sodium-chloride cotransporter NCC. Science Advances8, eadd7176. (*: corresponding)

2. Jinghua Xu, Jiuqing Wang, Aijun Liu, Yanqing Zhang*, Xiang Gao*. (2021). Structural and functional analysis of SsaV cytoplasmic domain and variable linker states in the context of the InvA-SsaV chimeric protein. Microbiology Spectrum9, e0125121. (*: corresponding)

3. Yanqing Zhang^#, Sai Li^#, Chao Zeng^#, Gaoxingyu Huang^#, Xuechen Zhu^#, Qifan Wang, Kunpeng Wang, Qiang Zhou, Chuangye Yan, Wusheng Zhang, Guangwen Yang, Minhao Liu, Qinghua Tao, Jianlin Lei, Yigong Shi*. (2020). Molecular architecture of the luminal ring of the Xenopus laevis nuclear pore complex. Cell Research30, 532-540. Featured on the COVER; F1000Prime Recommendation

4. Gaoxingyu Huang^#, Yanqing Zhang^#, Xuechen Zhu^#, Chao Zeng^#, Qifan Wang, Qiang Zhou, Qinghua Tao, Minhao Liu, Jianlin Lei, Chuangye Yan, Yigong Shi*. (2020). Structure of the cytoplasmic ring of the Xenopus laevis nuclear pore complex by cryo-electron microscopy single particle analysis. Cell Research30, 520-531.

5. Qiang Su^#, Feizhuo Hu^#, Yuxia Liu^#, Xiaofei Ge, Changlin Mei, Shengqiang Yu, Aiwen Shen, Qiang Zhou, Chuangye Yan, Jianlin Lei, Yanqing Zhang*, Xiaodong Liu* & Tingliang Wang*. (2018). Cryo-EM structure of the polycystic kidney disease-like channel PKD2L1. Nature Communications9, 1192. (*: corresponding)

6. Yanqing Zhang^#, Zhengtao Xiao^#, Qin Zou, Jianhuo Fang, Qifan Wang, Xuerui Yang*, Ning Gao*. (2017). Ribosome profiling reveals genome-wide cellular translational regulation upon heat stress in Escherichia coli. Genomics Proteomics & Bioinformatics15, 324-330.

7. Yanqing Zhang, Chandra Sekhar Mandava, Wei Cao, Xiaojing Li, Dejiu Zhang, Ningning Li, Yixiao Zhang, Xiaoxiao Zhang, Yan Qin, Kaixia Mi, Jianlin Lei*, Suparna Sanyal*, Ning Gao*. (2015). HflX is a ribosome-splitting factor rescuing stalled ribosomes under stress conditions. Nature Structural & Molecular Biology 22, 906-913.