代表性论文
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  • Guo X, Wang L, Li J ,Ding Z ,Xiao J ,Yin X ,He S ,Shi P ,Dong L, Li G ,Tian C ,Wang J ,Cong Y ,Xu Y. Structural insight into autoinhibition and histone H3-induced activation of DNMT3A. Nature. Jan 29 2015;517(7536):640-644.

  • Hu L, Lu J, Cheng J, Rao Q, Li Z, Hou H, Lou Z, Zhang L, Li W, Gong W, Liu M, Sun C, Yin X, Li J, Tan X, Wang P, Wang Y, ,Fang D, Cui Q, Yang P, He C, Jiang H, Luo C, Xu Y. Structural insight into substrate preference for TET-mediated oxidation. Nature. Nov 5 2015;527(7576):118-122.

  • Sun Y, Feng W, Yang P, Huang C, Li F. The biosafety of lanthanide upconversion nanomaterials. Chemical Society reviews. Mar 21 2015;44(6):1509-1525.

  • Zhang Y, Zhang C, Jiang H, Yang P, Lu H. Fishing the PTM proteome with chemical approaches using functional solid phases. Chemical Society reviews. Nov 21 2015;44(22):8260-8287.

  • Qiu Z, Guo W, Wang Q, Chen Z ,Huang S, Zhao F, Yao M, Zhao Y, He X. Yuan HX, Guan KL. The SIN1-PH Domain Connects mTORC2 to PI3K. Cancer discovery. Nov 2015;5(11):1127-1129.

  • Chen M ,Guo Q ,Wang Y ,Zou Y, Wang G ,Zhang X ,Xu X ,Zhao M ,Hu F ,Qu D, Chen M, Wang M. Shifts in the Antibiotic Susceptibility, Serogroups, and Clonal Complexes of Neisseria meningitidis in Shanghai, China: A Time Trend Analysis of the Pre-Quinolone and Quinolone Eras. PLoS medicine. Jun 2015;12(6):e1001838; discussion e1001838.

  • Wang Y, Xiao M, Chen X, Chen L, Xu Y, Lv L, Wang P, Yang H, Ma S, Lin H, Jiao B, Ren R, Ye D, Guan KL, Xiong Y . WT1 recruits TET2 to regulate its target gene expression and suppress leukemia cell proliferation. Molecular cell. Feb 19 2015;57(4):662-673.

  • Yang Y1, Yin X1, Yang H1, Xu Y. Histone demethylase LSD2 acts as an E3 ubiquitin ligase and inhibits cancer cell growth through promoting proteasomal degradation of OGT. Molecular cell. Apr 2 2015;58(1):47-59.

  • Zha Z, Han X, Smith MD, Liu Y, Giguère PM, Kopanja D, Raychaudhuri P, Siderovski DP, Guan KL, Lei QY, Xiong Y. A Non-Canonical Function of Gbeta as a Subunit of E3 Ligase in Targeting GRK2 Ubiquitylation. Molecular cell. Jun 4 2015;58(5):794-803.

  • Li F, He X, Ye D, Lin Y, Yu H, Yao C, Huang L, Zhang J, Wang F, Xu S, Wu X, Liu L, Yang C, Shi J, He X, Liu J, Qu Y, Guo F, Zhao J, Xu W, Zhao S. NADP+-IDH Mutations Promote Hypersuccinylation that Impairs Mitochondria Respiration and Induces Apoptosis Resistance. Molecular cell.Nov 19 2015; 60(4):661-75.

  • Zhou X, Wang S, Wang Z, Feng X, Liu P, Lv XB, Li F, Yu FX, Sun Y, Yuan H, Zhu H, Xiong Y, Lei QY, Guan KL. Estrogen regulates Hippo signaling via GPER in breast cancer. The Journal of clinical investigation. May 2015;125(5):2123-2135.

  • Li Y, Zheng Q, Bao C, Li S, Guo W, Zhao J, Chen D, Gu J, He X, Huang S. Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis.Cell research. Aug 2015;25(8):981-984.

  • Gong R, Hong AW, Plouffe SW, Zhao B, Liu G, Yu FX, Xu Y, Guan KL .Opposing roles of conventional and novel PKC isoforms in Hippo-YAP pathway regulation. Cell research. Aug 2015;25(8):985-988.

  • Wang Z, Wan Y, Qiu C, Quiñones-Parra S, Zhu Z, Loh L, Tian D, Ren Y, Hu Y, Zhang X, Thomas PG, Inouye M5 Doherty PC, Kedzierska K ,Xu J. Recovery from severe H7N9 disease is associated with diverse response mechanisms dominated by CD8(+) T cells. Nature communications. 2015;6:6833.

  • Cheng J ,Yang H ,Fang J ,Ma L ,Gong R, Wang P, Li Z, Xu Y. Molecular mechanism for USP7-mediated DNMT1 stabilization by acetylation. Nature communications. 2015;6:7023.

  • Jia M, Shan Z, Yang Y, Liu C, Li J, Luo ZG, Zhang M, Cai Y, Wen W, Wang W. The structural basis of Miranda-mediated Staufen localization duringDrosophila neuroblast asymmetric division. Nature communications. 2015;6:8381.

  • Yang HB, Xu YY, Zhao XN, Zou SW, Zhang Y, Zhang M, Li JT, Ren F, Wang LY, Lei QY. Acetylation of MAT IIalpha represses tumour cell growth and is decreased in human hepatocellular cancer. Nature communications. 2015;6:6973.

  • Cai JB ,Shi GM ,Dong ZR ,Ke AW ,Ma HH ,Gao Q ,Shen ZZ ,Huang XY ,Chen H ,Yu DD ,Liu LX,Zhang PF ,Zhang C ,Hu MY ,Yang LX ,Shi YH ,Wang XY ,Ding ZB ,Qiu SJ ,Sun HC ,Zhou J ,Shi YG ,Fan J Ubiquitin-specific protease 7 accelerates p14(ARF) degradation by deubiquitinating thyroid hormone receptor-interacting protein 12 and promotes hepatocellular carcinoma progression. Hepatology.May 2015;61(5):1603-1614.

  • Wang ZC, Gao Q, Shi JY, Guo WJ, Yang LX, Liu XY, Liu LZ, Ma LJ, Duan M, Zhao YJ, Wu YN, Gao DM, Wang XY, Shi GM, Ding ZB, Ke AW, Tang QQ, Cao Y, Zhou J, Fan J. Protein tyrosine phosphatase receptor S acts as a metastatic suppressor in hepatocellular carcinoma by control of epithermal growth factor receptor-induced epithelial-mesenchymal transition. Hepatology. 2015 Oct;62(4):1201-1214.

  • Guo W, Qiu Z, Wang Z, Wang Q, Tan N, Chen T, Chen Z, Huang S, Gu J, Li J, Yao M, Zhao Y, He X. MiR-199a-5p is negatively associated with malignancies and regulates glycolysis and lactate production by targeting hexokinase 2 in liver cancer. Hepatology. Oct 2015;62(4):1132-1144.

  • Yuan HX, Wang Z, Yu FX, Li F, Russell RC, Jewell JL, Guan KL .NLK phosphorylates Raptor to mediate stress-induced mTORC1 inhibition. Genes Dev. Nov 15 2015;29(22):2362-2376.

  • Zhang B, Wang L, Zeng L, Zhang C, Ma H. Arabidopsis TOE proteins convey a photoperiodic signal to antagonize CONSTANS and regulate flowering time. Genes Dev. May 1 2015;29(9):975-987.

  • Hui Yang, Lisha Zhou, Qian Shi, Yuzheng Zhao, Huaipeng Lin, Mengli Zhang, Shimin Zhao, Yi Yang, Zhi‐Qiang Ling, Kun‐Liang Guan, Yue Xiong, Dan Ye. SIRT3-dependent GOT2 acetylation status affects the malate-aspartate NADH shuttle activity and pancreatic tumor growth. The EMBO journal. Apr 15 2015;34(8):1110-1125.

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