课题组长
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  • 马端

    医学博士,教授,博士生导师
    复旦大学基础医学院教授,复旦大学儿科医院兼职教授
    地址:上海市东安路130号13号楼519
    电话:021-54237441(办公室),021-54237414(实验室)
    邮箱:duanma@fudan.edu.cn
    实验室主页:http://mdlab.fudna.edu.cn

工作经历
副主任,复旦大学出生缺陷研究中心(2008-至今)
教授/副主任,复旦大学代谢分子医学教育部重点实验室(2002.3-至今)
博士后,美国新墨西哥大学医学院病理系(2000-2002)
博士后,中国医学科学院/北京协和医科大学/北京协和医院(1998-2000)
主任/副主任医师,山东省血栓病研究中心(1989-2000)
住院医师,河南安阳钢铁公司李珍铁矿职工医院(1983-1985)
教育经历
博士,上海医科大学分子遗传(生物化学分子生物学系)(1995-1998)
硕士,山东医科大学内科血液学(1985-1988)
大学,武汉科技大学医学院医疗系(1979-1982)
所获人才项目
上海市领军人才(2013)
上海市优秀学术带头人(2012)
上海市曙光学者(2002)
所获奖项
中国妇幼健康科技奖一等奖(2015)
华东地区科技出版社优秀科技图书一等奖,临床遗传学(2014)
上海图书奖一等奖,临床遗传学(2014)
上海市优秀图书一等奖,生物学前沿技术在医学研究中的应用(2008)
上海市第四届徐光启科技银奖(2006)
上海市生物工程学会荣誉奖(2004)
上海市科技进步三等奖(2003)
上海市优秀发明选拔赛一等奖(2002)
社会学术机构任职
中华医学会医学遗传学分会,副主任委员
中国医师协会医学遗传分会临床遗传学专委会,副主任委员
中国中西医结合学会耳鼻咽喉科专业委员会耳聋基因专家委员会,副主任委员
中国遗传学会,理事
中国遗传学会遗传咨询分会,顾问
中华预防医学会出生缺陷预防与控制专业委员会,委员
上海市遗传学会,理事
上海市医学会医学遗传学专业委员会,主任委员
上海市健康科技协会基因健康专委会,主任委员
上海市医学会罕见病专业委员会,副主任委员
上海市人口与发展专家咨询委员会,成员
上海市出生缺陷一级预防工作专家组,成员
上海市浦东新区科技发展基金,成员
专业杂志任职情况
副主编:中国产前诊断杂志(电子版)
常委:微循环杂志
编委:(1)BioScience Trends;(2)Journal of Otorhinolaryngology, Hearing and Balance Medicine;(3)中华医学遗传学杂志;(4)医学分子生物学;(5)中国临床神经科学;(6)转化医学杂志;(7)中华生殖与避孕杂志
研究方向
出生缺陷与遗传相关疾病的病因、发病机制、早期防治与临床转化。
代表论文
  1. Yang F, Chen C, Zhou Q, Gong Y, Li R, Li C, Klämpfl F, Freund S, Wu X, Sun Y, Li X, Schmidt M, Ma D*, Yu Y*. (2017) Laser beam melting 3D printing of Ti6Al4V based porous structured dental implants: fabrication, biocompatibility analysis and photoelastic study. Sci Rep 7:45360

  2. Ma J, Yang J, Jian W, Wang X, Xiao D, Xia W, Xiong L, Ma D*. (2017) A novel loss-of-function heterozygous BRCA2 c.8946_8947delAG mutation found in a Chinese woman with family history of breast cancer. J Cancer Res Clin Oncol 143(4):631-637

  3. Xiao JJ, Jin KY, Wang JP, Ma J, Zhang J, Jiang N, Wang HJ, Luo XP, Fei J, Wang ZG, Yang X, Ma D*. (2017) Conditional knockout of TFPI-1 in VSMCs of mice accelerates atherosclerosis by enhancing AMOT/YAP pathway. Int J Cardio 228:605-614

  4. Ma Z, Xia W, Liu F, Ma J, Sun S, Zhang J, Jiang N, Wang X, Hu J, Ma D*. (2016) SLC44A4 mutation causes autosomal dominant hereditary postlingual non-syndromic mid-frequency hearing loss. Hum Mol Genet Dec 2

  5. Wang J, Xiao J, Wen D, Wu X, Mao Z, Zhang J, Ma D*. (2016) Endothelial cell-anchored tissue factor pathway inhibitor regulates tumor metastasis to the lung in mice. Mol Carcinog  55(5):882-896

  6. Liang F, Diao L, Jiang N, Zhang J, Wang HJ, Zhou WH, Huang GY, Ma D*. (2015) Chronic exposure to ethanol in male mice may be associated with hearing loss in offspring. Asian J Androl 17(6):985-990

  7. Liu F, Yang F, Wen D, Xia W, Hao L, Hu J, Zong J, Shen X, Ma J, Jiang N, Sun S, Zhang J, Wang H, Wang X, Ma Z, Ma D*. (2015) Grhl1 deficiency affects inner ear development in zebrafish. Int J Dev Biol 59(10-12):417-423

  8. Wang Y, Wen Z, Shen J, Cheng W, Li J, Qin X, Ma D*, Shi Y*. (2014) Comparison of the performance of Ion Torrent chips in noninvasive prenatal trisomy detection. J Hum Genet 59(7):393-396

  9. Liang F, Diao L, Liu J, Jiang N, Zhang J, Wang H, Zhou W, Huang G, Ma D*. (2014) Paternal ethanol exposure and behavioral abnormities in offspring: Associated alterations in imprinted gene methylation. Neuropharmacology 81:126-133

  10. Xu F, Wang YL, Chang JJ, Du SC, Diao L, Jiang N, Wang H, Ma D*, Zhang J*. (2014) Mammalian sterile 20-like kinase 1/2 inhibits the Wnt/β-catenin signalling pathway by directly binding casein kinase 1ε. Biochem J 458(1):159-169

  11. Zhang J, Luo X, Ma XJ, Wu Y, Li WC, Wang HJ, Huang GY*, Ma D*. (2013) MicroRNA deregulation in right ventricular outflow tract myocardium in nonsyndromic tetralogy of fallot. Canadian Journal of Cardiology 29(12):1695-1703

  12. Zhang YL, Wang LN, Zhou WH, Zhang J, Wang HJ, Jiang Q, Deng SS, Li WH, Wang L, Li HW, Mao ZH, Ma D*. (2013) Tissue factor pathway inhibitor-2: A novel gene involved in zebrafish central nervous system development. Developemntal Biology 381(1):38-49

  13. Li J, Cao Y, Ma XJ, Wang HJ, Zhang J, Luo X, Chen W, Wu Y, Meng Y, Zhang J, Yuan Y, Ma D*, Huang GY*. (2013) Roles of miR-1-1 and miR-181c in ventricular septal defects. Int J Cardiol 168(2):1441-1446  

  14. Sheng W, Wang HJ, Zhang P, Qian YY, Wu Y, Ma XJ, Zheng FY, Chen L, Huang GY*, Ma D*. (2012) LINE-1Methylation Status and Its Association with Tetralogy of Fallot in Chinese Infants. BMC Medical Genomic 5:20

  15. Chen YT, Zhang J, Wang HJ, Xu C, Du YY, Luo X, Zheng FY, Zhao JY, Zhang HW, Ma D*. (2012) miRNA-135a promotes migration and invasion of breast cancer by targeting HOXA10. BMC Cancer 12(1):111

  16. Xu C, Deng F, Mao Z^, Zhang J, Wang H, Wang J, Mu J, Deng S, Ma D*. (2012) The interaction of the second Kunitz-type domain (KD2) of TFPI-2 with a novel interaction partner, prosaposin, mediates the inhibition of the invasion and migration of human fibrosarcoma cells. Biochemical Journal 441(2):665-674

  17. Zhang J, Du YY, Lin YF, Chen YT, Yang L, Wang HJ, Ma D*. (2008) The cell growth suppressor, mir-126, targets IRS-1. Biochem Biophys Res Commun 377(1):136-140

  18. Guo HS, Kong DS, Lin YF, Zhang HW, Liu J, Zhang N, Song HY, Tang QQ, Ma D*. (2007) Tissue factor pathway inhibitor-2 could be repressed by CpG hypermethylation through inhibition of KLF6 binding in high metastatic breast cancer cell MDA-MB-435. BMC Molecular Biology 8:110

  19. Lin YF, Zhang N*, Guo HS, Kong DS, Jiang T, Liang W, Zhao ZH, Liu J, Tang QQ, Ma D*. (2007) Recombinant tissue factor pathway inhibitor induces apoptosis in cultured rat mesangial cells via its Kunitz-3 domain and C-terminal through inhibiting PI3-kinase/Akt pathway. Apoptosis 12(12):2163-2173

  20. Bai H, Ma D*, Zhang YG, Zhang N, Kong DS, Guo HS, Mo W, Tang QQ, Song HY. (2005) Molecular Design and Characterization of Recombinant Long Half-life Human Tissue Factor Pathway Inhibitor Mutants. Thrombosis and Haemostasis 93:1055-1060

  21. Xia W, Hu J, Liu F, Ma J, Sun S, Zhang J, Jin K, Huang J, Jiang N, Wang X, Li W, Ma Z, Ma D*. New role of LRP5, associated with non-syndromic autosomal recessive hereditary hearing loss. Hum Mutat. 2017 Jul 4. doi: 10.1002/humu.23285. [Epub ahead of print]

  22. Qian Y, Xiao D, Guo X, Chen H, Hao L, Ma X, Huang G, Ma D*, Wang H. Hypomethylation and decreased expression of BRG1 in the myocardium of patients with congenital heart disease. Birth Defects Res. Birth Defects Res. 2017 Jun 24.

  23. Shi Q, Xiong B, Zhong J, Wang H, Ma D*, Miao C. MFHAS1 suppresses TLR4 signaling pathway via induction of PP2A C subunit cytoplasm translocation and inhibition of c-Jun dephosphorylation at Thr239. Mol Immunol. 2017;88:79-88

  24. Yang J, Jin K, Xiao J, Ma J, Ma D. Endogenous tissue factor pathway inhibitor in vascular smooth muscle cells inhibits arterial thrombosis. Front Med. 2017 May 27. doi: 10.1007/s11684-017-0522-y.

  25. Zhong J, Wang H, Chen W, Sun Z, Chen J, Xu Y, Weng M, Shi Q, Ma D, Miao C. Ubiquitylation of MFHAS1 by the ubiquitin ligase praja2 promotes M1 macrophage polarization by activating JNK and p38 pathways. Cell Death Dis. 2017;8(5):e2763.

  26. Qian Y, Xiao D, Guo X, Chen H, Hao L, Ma X, Huang G, Ma D, Wang H. Multiple gene variations contributed to congenital heart disease via GATA family transcriptional regulation. J Transl Med. 2017;15(1):69.

  27. Yang F#, Chen C#, Zhou Q, Gong Y, Li R, Li C, Klämpfl F, Freund S, Wu X, Sun Y, Li X, Schmidt M, Ma D, Yu Y. Laser beam melting 3D printing of Ti6Al4V based porous structured dental implants: fabrication, biocompatibility analysis and photoelastic study. Sci Rep. 2017;7:45360.

  28. Ma J, Yang J, Jian W, Wang X, Xiao D, Xia W, Xiong L, Ma D. A novel loss-of-function heterozygous BRCA2 c.8946_8947delAG mutation found in a Chinese woman with family history of breast cancer. J Cancer Res Clin Oncol. 2017;143(4):631-637.

  29. Ma Z, Xia W, Liu F, Ma J, Sun S, Zhang J, Jiang N, Wang X, Hu J, Ma D. SLC44A4 mutation causes autosomal dominant hereditary postlingual non-syndromic mid-frequency hearing loss. Hum Mol Genet. 2017;26(2):383-394.

  30. Xiao JJ, Jin KY, Wang JP, Ma J, Zhang J, Jiang N, Wang HJ, Luo XP, Fei J, Wang ZG, Yang X, Ma D*. Conditional knockout of TFPI-1 in VSMCs of mice accelerates atherosclerosis by enhancing AMOT/YAP pathway. Int J Cardio. 2017;228:605-614

授权发明专利

  1. Duan Ma, Jingui Mu, Jiping Wang, Huijun Wang, Wang Liang. Genetically Modified TFPI And Method Of Treating Coagulation using the same. USA Patent No. 8912143

  2. Duan Ma, Jingui Mu, Jiping Wang, Huijun Wang, Wang Liang. Genetically Modified TFPI And Method Of Making The Same. USA Patent No. US 20120065135

  3. 马端,张进,王慧君,杨璐。一种检测DNA主动去甲基化的方法。专利号:ZX201110077002.7

  4. 马端,木金贵,王际平,王慧君,梁旺。一种酵母高效表达长效重组人组织因子途径抑制物的方法。专利号:ZL200910046024x

  5. 马端,程训佳,刘静,木金贵,梁旺,王际平。一种人源抗组织因子Fab及其制备方法。专利号:ZL200810034154.7

  6. 马端,宋后燕。重组人组织因子途径抑制物活性肽及其制备。专利号:ZL011 26949.9

  7. 马端,宋后燕,白浩,张农。长效重组组织因子途径抑制物及其制备方法。专利号:ZL03151203.8

著作

  1. 遗传病相关个体化医学检测技术指南(试行)。共同起草人。国家卫计委个体化医学检测技术专家委员会。2014

  2. 常见出生缺陷产前诊断的行业规范与指南,副主编。人民卫生出版社。2013

  3. 临床遗传学,共同主编。上海科技出版社。2013

  4. 免疫生物学/Immunobiology,共同主译。人民卫生出版社。2008

  5. 生物学前沿技术在医学研究中的应用,主编。复旦大学出版社。2007

  6. 分子医学导论,副主编。复旦大学出版社,2006

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