重点重大专项首席
首页 > 人才队伍 > 重点重大专项首席
  • 雷群英

    博士,教授,博士生导师
    地址:东安路131号,明道楼701室,上海 200032
    电话:021-54237935(办公室),021-54237902(实验室)
    邮箱:qlei@fudan.edu.cn,fudanlqy2014@163.com
    实验室主页:http://www.cancermetabolism.fudan.edu.cn
    代谢应激和肿瘤发生发展中蛋白质修饰动态调控及生理病理效应(2015.01-2019,08,获批经费:1500万)

工作经历
教授,复旦大学,肿瘤医院/生物医学研究院,(2017.01~至今)
教授,复旦大学,基础医学院/生物医学研究院,(2009.11~2016.12)
副教授,复旦大学,基础医学院/生物医学研究院,(2006.03~2009.10)
博士后,加州大学洛杉矶分校,分子药理学系,(2002.09~2006.01)
预防医师,江西进贤疾控中心,(1993.07-1996.08)
教育经历
博士,复旦大学上海医学院,生物化学与分子生物学系,(1999.09~2002.07)
硕士,苏州大学苏州医学院,生物化学与分子生物学系,(1996.09~1999.07)
学士,南昌大学江西医学院,预防医学,(1988.09-1993.07)
所获人才项目
万人计划,科技部,2016
长江学者特聘教授,教育部,2015
中青年科技创新领军人才,科技部,2014
上海市优秀学术带头人,上海市科委,2013
国家杰出青年科学基金,国家自然科学基金,2012
曙光学者,上海市教委,2011
上海市卫生系统优秀学术带头人,上海市卫计委,2011
新世纪优秀人才,教育部,2009
浦江人才计划,上海市科委,2007
所获奖项
上海市三八红旗手标兵,上海市妇联,2016
上海市自然科学牡丹奖,上海市科协,2015
五洲女子科技奖,中国女医师协会,2015
自然科学二等奖,教育部,2014
中国青年女科学家奖,联合教科文组织,2013
自然科学一等奖,教育部,2012
上海市三八红旗手,上海市妇联,2012
明治生命科学奖(杰出奖),国家人类基因组南方研究中心,2011
研究方向
代谢异常和肿瘤发生,尤其关注肿瘤细胞对内外代谢物的感受利用,期望为肿瘤代谢修正治疗提供理论支持和潜在靶点。
代表论文
  1. Xia S, Lin R, Jin L, Zhao L, Kang HB, Pan Y, Liu S, Qian G, Qian Z, Konstantakou E, Zhang B, Dong JT, Chung YR, Abdel-Wahab O, Merghoub T, Zhou L, Kudchadkar RR, Lawson DH, Khoury HJ, Khuri FR, Boise LH, Lonial S, Lee BH, Pollack BP, Arbiser JL, Fan J* Lei QY*, Chen J*. Prevention of Dietary-Fat-Fueled Ketogenesis Attenuates BRAF V600E Tumor Growth. Cell Metabolism. 2017, 25(2):358-373
    Highlights: Nature

  2. Zhang Y#, Xu YY#, Zhao XN, Li JT, Yang HB, Zhang M, Li, Yao CB, Yin M*, Chen J*, Lei QY*. (2016). Acetylation targets HSD17B4 for degradation via CMA pathway in response to E1. Autophagy. 2017, 13(3):538-553.

  3. Wang YP*,Wang J,Gao X, Xu YY, Cheng JK*, Lei QY*. Arginine Methylation of MDH1 by CARM1 Inhibits Non-canonical Glutamine Metabolism and Suppresses Pancreatic Cancer. Molecular Cell. 2016;64, 673–687
    Highlights: Cancer discovery

  4. Gao X#, Lin SH#, Ren F, Li JT, Chen JJ, Yao CB, Yang HB, Jiang SX, Yan GQ, Wang D, Wang Y, Liu Y, Cai Z, Xu YY, Chen J, Yu W, Yang YP*, Lei QY*. Acetate Functions as an Epigenetic Metabolite to Promote Lipid Synthesis under Hypoxia. Nature Commun. 2016 Jun 30;7:11960.

  5. Yang, HB#., Xu, YY#*., Zhao, XN, Zou SW*., Zhang Y., Zhang M., Li JT, Ren F., Wang LY., Lei QY*. Acetylation of MAT IIα represses tumour cell growth and is decreased in human hepatocellularcancer. Nature Commun. 2015 Apr 30;6:6973.

  6. Zha, ZY., Han, XR., Matthew D. Smith, Liu, Y., Patrick M. Giguère, DraganaKopanja, PradipRaychaudhuri, David P. Siderovski, Guan, KL*., Lei, QY.*, and Xiong, Y*. A non- canonical function of Gβ as a subunit of E3 ligase in targeting GRK2 ubiquitylation. Molecular Cell. 2015;58(5):794-803

  7. Zhou, X#., Wang, SY#., Wang, Z., Feng, X., Liu, P., Lv, X-B., Li, F-L., Yu, F-x., Sun,YP., Yuan, HX., Zhu, HG., Xiong,Y*., Lei, QY*., Guan, KL*. Estrogen Activates TAZ via GPER in Invasive Ductal Breast Carcinoma. J Clin Invest. 2015;125(5):2123-35

  8. Zhao, D., Mo, Y., Li, MT., Zou,SW., Cheng, ZL., Sun, Y-P., Xiong, Y*., Guan, KL*., Lei, QY*.NOTCH-induced aldehyde dehydrogenase 1A1 deacetylation promotes breast cancer stem cells. J Clin Invest. 2014;124(12):5453-65

  9. Li T, Liu F, Feng X, Wang Z, Das I, Xu Y, Zhou X, Sun Y, Guan KL , Xiong Y, Lei QY*. Glyceraldehyde-3-phosphate Dehydrogenase Is Activated by Lysine 254 Acetylation in Response to Glucose Signal. J. Biol. Chem. 2014;289(6):3775-85

  10. Lv L#, Xu Y#, Zhao D, Li F, Wang W, Sasaki N, Jiang Y, Zhou X, Li T, Guan KL*, Lei QY* and Xiong Y*. Mitogenic and oncogenic stimulation of K433 acetylation promote PKM2 protein kinase activity and nuclear localization. Molecular Cell. 2013;52, 340–352
    Highlights:Cover story in Molecular cell, Highlight by Nature Review in Cancer and Cancer discovery

  11. Lin R#, Ren T#, Gao X, Zhou X, Li T, Xiong Y, Guan KL, Lei QY*. Acetylation Stabilizes ATP- citrate Lyase to Promote Lipid Biosynthesis and Tumor Growth. Molecular Cell. 2013;51, 506–518

  12. Zhao D#, Zou S#, Liu Y, Zhou X, Mo Y, Wang P, Xu Y, Dong B, Xiong Y*, Lei QY* and Guan KL*., Lysine-5 Acetylation Negatively Regulates Lactate Dehydrogenase A and Is Decreased in Pancreatic Cancer. Cancer Cell. 2013;23, 464-476

  13. Zhou X, Li T, Feng X, Hsiang E, Xiong Y, Guan KL , Lei QY*. Targeted polyubiquitylation of RASSF1C by the Mule and SCFβ-TrCP ligases in response to DNA damage. Biochem J. 2012441(1): 227-36.

  14. Lv L, Li D, Zhao D, Lin R, Chu Y,Zhang H, Zha Z, Ying Liu, Li Z, Xu Y, Huang Y, Gang W, Xiong Y, Guan KL, and Lei QY*. Acetylation Targets the M2 Isoform of Pyruvate Kinase for Degradation through Chaperone-Mediated Autophagy and Promotes Tumor Growth. Molecular Cell. 2011;42, 719-730
    Feature article Highlights: Preview in Molecular Cell, Science Signaling, Faculty of 1000

Top