课题组长
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  • 刘银坤

    博士,教授,博士生导师
    地址:东安路131号 明道楼615室,上海200032
    电话:021-54237959(办公室),021-54237963,021-54237962(实验室)
    传真:021-54237959
    邮箱:liu,yinkun@zs-hospital.sh.cn; ykliu201110@aliyun.com

工作经历
1982-1985 生物化学助教
1986- 1989.04 生物化学讲师
1989.05-1995.12 生物化学副教授,教授,基础医学院副院长兼生化系副主任
1995.12- 2014 复旦大学肝癌研究所教授,副所长兼实验室主任,IBS双聘PI
2014-现在 复旦大学肝癌研究所教授,IBS双聘PI
教育经历
1962-1968 上海医科大学医学系
1979-1982 上海医科大学生物化学研究生
1982.10 获医学硕士学位
1985-1986 美国密执安州立大学生化系访问学者
1988.05 获医学博士学位
1994.4-12 挪威Radium医院癌症研究所生化系访问学者
1995.01-05 日本生物科学和人体工学研究所生物大分子研究组客座研究员
1996.11-12, 1997-1998, 1999.05-07
日本工业技术研究院产业融合研究所仿生学研究组客座研究员
2000.01-05 美国耶鲁大学儿科系客座研究员
所获奖项
1990 “作出突出贡献的中国博士学位获得者”称号(国家教委,国务院学位办)
1991 “黄曲霉素酶联免疫媳妇测定与肝癌关系的研究”获国家教委科技进步奖三等
1995 “国产RU486或炔诺酮合并前列腺素抗早孕机理及临床研究” 获上海市科技进步奖
三等奖
2002 “高转移人肝癌裸鼠模型和细胞株的建立、研究和应用” 获中华科技奖一等奖 2003 “高转移人肝癌裸鼠模型和细胞株的建立、研究和应用” 上海市科学技术进步奖一
等奖
2003 “胚泡着床过程相关因子的表达、功能调节及其在生育调节中的意义” 获上海科学
技术进步奖二等奖
2006 “高转移人肝癌裸鼠模型和细胞株的建立、研究和应用”获国家科技进步奖一等奖(No.3)
2008 “肝癌门静脉癌栓形成机制及多模式综合治疗技术”获国家科技进步二等奖(No.9)

2009 国家自然科学二等奖
研究方向
1. 肝癌复发转移的分子机理及基于组织、血清的分子标志物和预测体系的建立; 2.肝癌的发生、发展及转移复发的蛋白质组学(表达谱;糖基化修饰谱及生物信息学分析和系统生物学); 3.肿瘤干细胞的分离纯化及作用的研究; 4.新型抗肝癌转移复发的抗黏附药物的基因工程生产及药效学研究。
代表论文

参与“医学大百科全书”、“人类疾病的动物模型”、“糖尿病学”、“糖复合物与疾病”、“小儿肝胆系统疾病”和“原发性肝癌复发转移的基础和临床”(副主编)等专业书籍的编写。发表论文共250篇,其中SCI、EI收录96篇。

  1. Shu Zhang, Hong Shu, Kaixuan Luo, Xiaonan Kang, Ying Zhang, Haojie Lu and Yinkun Liu. N-linked glycan changes of serum haptoglobin β chain in liver disease patients. Mol. BioSyst (2011) 7,1621-1628

  2. Hong Shu, Shu Zhang, Xiao-Nan Kang, Shan Li, Xue Qin, Chun Sun, HaoJie Lu, YinKun Liu. Protein expression and fucosylated glycan of serum haptoglobin β subunit in HBV based liver diseases. ACTA BIOCH BIOPH SIN (2011) 43(7):528-534

  3. Jin GZ, Li Y, Cong WM, Yu H, Dong H, Shu H, Liu X, Yan GQ, Zhang L, Zhang Y, Kang X, Guo K, Wang ZD, Yang PY, Liu YK. iTRAQ-2DLC-ESI-MS/MS Based Identification of a New Set of Immunohistochemical Biomarkers for Classification of Dysplastic Nodules and small Hepatocellular Carcinoma. J Proteome Res (2011) 10(8):3418-28

  4. Cun Wang, Kun Guo, Dongmei Gao, Xiaonan Kang, Kai Jiang, Yan Li, Lu Sun, Shu Zhang, Chun Sun, Xiaohui Liu, Weizhong Wu, Pengyuan Yang, Yinkun Liu. Identification of Transaldolase as a Novel Serum Biomarker for Hepatocellular Carcinoma Metastasis Using Xenografted Mouse Model and Clinic Samples. Cancer Letter (2011) 313:154-166

  5. Shu Zhang, Xiaohui Liu, Xiaonan Kang, Chun Sun, Haojie Lu, Pengyuan Yang, Yinkun Liu. iTRAQ plus 18O: a new technique for target glycoprotein analysis. Talanta (2012) 91:122-127

  6. Kun Guo, Lin Gan, Shu Zhang, Jiefeng Cui, Wang Cun, Yan Li, Xiaonan Kang, Meidong Gao, Yinkun Liu. Translocation of HSP27 into liver cancer cell nucleus may be associated with phosphorylation and O-GlcNAc glycosylation. Oncol Rep (2012) 12(5):1-7

  7. Xiaonan Kang, Nian Wang, Chen Pei, Lu Sun, Ruixia Sun, Jie Chen, Yinkun Liu. Glycan-related gene expression signatures in human metastatic hepatocellular carcinoma cells. Experimental and Therapeutic Medicine (2012) 3:415-422

  8. Cun Wang, Kun Guo, Kai Jiang, Dongmei Gao, Xiaonan Kang, Yan Li, Lu Sun, Shu Zhang, Chun Sun, Haiyan Sun, Xiaohui Liu, Weizhong Wu, Pengyuan Yang, Yinkun Liu. Tumor-derived secretory clusterin induces epithelial–mesenchymal transition and facilitates hepatocellular carcinoma metastasis. International J Biochenistry and cell biology (2012) 44: 2308-2320

  9. Cun Wang, Dongmei Gao, Kun Guo, Xiaonan Kang, Kai Jiang, Chun Sun, Yan Li, Lu Sun, Hong Shu, Guangzhi Jin, Haiyan Sun, Weizhong Wu and Yinkun Liu. Novel synergistic antitumor effects of rapamycin with bortezomib on hepatocellular carcinoma cells and orthotopic tumor model. BMC Cancer (2012) 12(1):166-178

  10. Chun Sun, Pei Chen, Qiaopei Chen, Lu Sun, Xiaonan Kang, Xue Qin, Yinkun Liu. Serum Paraoxonase 1 (PON1) heteroplasmon, a fucosylated and sialylated glycoprotein in distinguishing early hepatocellular carcinoma from liver cirrhosis patients. Acta Biochem Bioph Sin (2012) 44(9):765-773

  11. Sun Chun, Sun Lu, Jiang Kai, Gao Dongmei, Kang Xiaonan, Wang Cun, Zhang, Shu, Huang Shan, Qin Xue, Li, Yan, Liu YinKun. NANOG promotes liver cancer cell invasion by inducing epithelial-mesenchymal transition through NODAL/SMAD3 signaling pathway. International J Biochem Cell Biol (2013) 45(6):1099-1108

  12. Cun Wang, Kai Jiang, Dongmei Gao, Xiaonan Kang Chun Sun, Qinle Zhang, Yan Li, Lu Sun, Shu Zhang, Kun Guo, Yinkun Liu. Clusterin Protects Hepatocellular Carcinoma Cells from Endoplasmic Reticulum Stress induced Apoptosis through GRP78. PLoS ONE (2013) 8(2): e55981

  13. Xue Qin, Qiaopei Chen, Chun Sun, Cun Wang, Qiliu Peng, Li Xie, Yinkun Liu, Shan Li. High-throughput screening of tumor metastatic-related differential glycoprotein in hepatocellular carcinoma by iTRAQ combines lectin-related techniques. Med Oncol (2013) 30:420

  14. Cun Wang, Kai Jiang, Dongmei Gao, Xiaonan Kang Chun Sun, Qinle Zhang, Yan Li, Lu Sun, Shu Zhang , Kun Guo, Yinkun Liu. Clusterin Protects Hepatocellular Carcinoma Cells from Endoplasmic Reticulum Stress induced Apoptosis through GRP78 . PLoS ONE (2013) 8(2): e55981

  15. Chun Sun, Lu Sun, Yan Li, Xiaonan Kang, Shu Zhang, Yinkun Liu. Sox2 expression predicts poor survival of hepatocellular carcinoma patients and it promotes liver cancer cell invasion by activating Slug. Med Oncol. (2013) 30(2):503

  16. Chun Sun, Lu Sun, Kai Jiang, Dong-mei Gao, Xiao-nan Kang, Cun Wang, Shu Zhang, Shan Huang, Xue Qin, Yan Li, Yin-kun Liu. Nanog promotes liver cancer invasion by inducing epithelial-mesenchymal transition through NODEL/SMAD3 signaling pathway. The Inter J of Biochem Cell Biol (2013) 45(6):1099-1108

  17. Shu Zhang, Kai Jiang, Chun Sun, Haojie Lu, Yinkun Liu. Quantitative analysis of site-specific N-glycans on sera haptoglobin β chain in liver diseases. Acta Biochim Biophys Sin (2013) 45(12):1021-1029

  18. Tianhua Liu, Shu Zhang, Jie Chen, Kai Jiang Qinle Zhang, Kun Guo, Yinkun Liu. The Transcriptional Profiling of Glycogenes associated with Hepatocellular Carcinoma Metastasis. PLoS ONE (2014) 9(9): e107941

  19. Shu Zhang, Kai Jiang, Qinle Zhang, Kun Guo, Yinkun Liu. Serum fucosylated paraoxonase 1 as a potential glycobiomarker for clinical diagnosis of early hepatocellular carcinoma using ELISA Index. Glycoconj J (2015) 32(9):119-125

  20. Zhang Qinle, Jiang Kai, Li Yan, Gao Dongmei, Sun L, Zhang Shu, Liu Tianhua, Guo Kun, Liu Yinkun. Histidine-rich glycoprotein function in hepatocellular carcinoma depends on its N-glycosylation status, and it regulates cell proliferation by inhibiting Erk1/2 phosphorylation. Oncotarget (2015) 6(30):30222-30231

  21. Kai Jiang, Shuxin Shang, Wei Li, Kun Guo, Xue Qin, Shu Zhang, Yinkun Liu. Multiple lectin assays for detecting glyco-alteration of serum GP73 in liver diseases. Glycoconj J (2015) 32(9):1-8

  22. Kai Jiang, Wei Li, Qinle Zhang, Guoquan Yan, Kun Gu, Shu Zhang, Yinkun Liu. GP73 N-glycosylation at Asn144 reduces hepatocellular carcinoma cell motility and invasiveness. Oncotarget (2016) 7(17):23530-41

  23. Lu Sun, Tianhua Liu, Shu Zhang, Kun Guo, Yinkun Liu. Oct4 induces EMT through LEF1/β-catenin dependent WNT signaling pathway in hepatocellular carcinoma. ONCOLOGY LETTERS (2017) 13: 2599-2606

  24. Cui Mo, Tianhua Liu, Shu Zhang, Kun Guo, Meng Li, Xue Qin, Yinkun Liu. Reduced N-Acetylglucosaminyltransferase III Expression via Smad3 and Erk Signaling in TGF-β1 induced HCC EMT Model. Discovery Medicine (2017) 23(124):7-17

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