课题组长
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  • 邓春晖

    博士,教授,博士生导师
    地址:邯郸路220号,复旦大学化学西楼320室,上海 200433
    电话:021-65643983(办公室)
    传真:021-65641740
    邮箱:chdeng@fudan.edu.cn
    实验室主页:http://www.hplc.fudan.edu.cn

工作经历
教授,复旦大学化学系(2010.2-至今)
副研究员,复旦大学化学系(2006.2-2010.2)
讲师,复旦大学化学系(2004.9-2006.2)
辅导员、助教,南昌大学共青学院(1992.9-1998.9)
教育经历
博士,复旦大学化学系(2001-2004)
硕士,复旦大学测试中心(1998-2001)
学士,兰州大学化学系(1988-1992)
所获人才项目
国家杰出青年科学基金,国家基金委,2014
所获奖项
科技进步二等奖(第二完成人),上海市科委,2015
自然科学二等奖(第一完成人),教育部,2012
明治生命科学奖(科学奖),国家人类基因组南方研究中心,2011
研究方向
本课题组主要开展基于功能化磁性纳米材料的蛋白质组学新技术新方法研究。针对蛋白质组学研究中面临的蛋白质酶解、丰度蛋白质和内源性肽富集、修饰蛋白质选择性分离富集方面的热点难点问题,开展了功能化磁性纳米材料的蛋白质快速酶解、低丰度蛋白质和内源性肽分离富集、修饰蛋白质选择性分离富集等研究工作。在国际重要杂志如Chem. Soc. Rev, Angew. Chem. Int. Ed., Adv. Mater., Anal. Chem.等,共发表研究论文200多篇。文章他引6000多次,单篇文章他引900多次,H因子为50。入选elsevier中国高被引学者,排名60位。
课题组长邓春晖主持和参与多项国家和省部级项目,包括主持了上海市重点项目、国家自然面上基金、国家杰出青年基金以及973课题等。
代表论文

1.        Li Y, Zhang XM, Deng CH*,2013Functionalized magnetic nanoparticles for sample preparation in proteomics and peptidomics analysis. Chem. Soc. Rev. 42, 8517-8539.

2.        Zhang XY, Zhu SC, Xiong Y, Deng CH*, Zhang XM* (2013)Development of a MALDI-TOF MS Strategy for the High-Throughput Analysis of Biomarkers: On-Target Aptamer Immobilization and Laser-Accelerated Proteolysis. Angew. Chem. Int. Ed. 52, 6055-6058.

3.        Yao GP, Deng CH*, Yang PY, Zhang XM (2010) Efficient Tryptic Proteolysis Accelerated by Laser Radiation for Peptide Mapping. Angew. Chem. Int. Ed. 49, 8185-8189 (VIP Paper).

4.        Liu SS, Chen HM,Lu XH, Deng CH*, Yang PY, Zhang XM (2010) Facile Synthesis of Cu2+-immobilized Magnetic Mesoporous Silica Microspheres for Selective Enrichment of Peptides for Mass Spectrometry Analysis. Angew. Chem. Int. Ed. 49, 7557-7561.

5.        Chen HM, Deng CH*, Zhang XM (2010)Synthesis of Fe3O4@SiO2@PMMA Core-Shell-Shell Magnetic Microspheres for Highly Efficient Enrichment of Peptides and Proteins for MALDI-ToF MS Analysis. Angew. Chem. Int. Ed., 49, 607 -611.

6.        Chen HM, Deng CH*, Li Y, Dai Y, Yang PY, and Zhang XM* (2009) A Facile Synthesis Approach to C8-Functionalized Magnetic Carbonaceous Polysaccharide Microspheres for the Highly Efficient and Rapid Enrichment of Peptides and Direct MALDI-TOF-MS Analysis. Adv. Mater. 21, 2200-2205.

7.        Deng YH, Qi DW, Deng CH*, Zhang XM, Zhao DY* (2008) Superparamagnetic High-Magnetization Microspheres with an Fe3O4@SiO2 Core and Perpendicularly Aligned Mesoporous SiO2 Shell for Removal of Microcystins. J. Am. Chem. Soc. 130 (1), 28-29.

8.        Yan YH, Sun XN, Deng CH*, Li Y*, Zhang XM (2014) Metal Oxide Affinity Chromatography Platform-Polydopamine Coupled Functional Two-Dimensional Titania Graphene Nanohybrid for Phosphoproteome Research. Anal. Chem. 86,4327-4332.

9.        Sun NR, Deng CH*, Li Y*, Zhang XM (2014) Highly Selective Enrichment of N-Linked Glycan by Carbon-Functionalized Ordered Graphene/Mesoporous Silica Composites. Anal. Chem. 86, 2246–2250.

10.     Yan YH, Zheng ZF, Deng CH*, Li Y*, Zhang XM, Yang PY (2013) Hydrophilic Polydopamine-Coated Graphene for Metal Ion Immobilization as a Novel Immobilized Metal Ion Affinity Chromatography Platform for Phosphoproteome Analysis. Anal. Chem. 85 (18), 8483–8487.

11.     Sun NR, Wang, Jiawen; Yao, Jizong; Deng, Chunhui*. (2017) Hydrophilic Mesoporous Silica Materials for Highly Specific Enrichment of N-Linked Glycopeptide. Anal. Chem. 89 (3), 1764-1771.

12.     Li YL, Wang JW, Sun NR*, Deng CH* (2017) Glucose-6-Phosphate-Functionalized Magnetic Microsphere as Novel Hydrophilic Probe for Specific Capture of N-Linked Glycopeptides. Anal. Chem. 89(20), 11151-11158.

13.     Yao JZ, Wang JW, Sun NR*, Deng CH* (2017) One-step functionalization of magnetic nanoparticles with 4-mercaptophenylboronic acid for a highly efficient analysis of N-glycopeptides. Nanoscale, 9 (41), 16024-16029.


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