重点重大专项首席
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  • 陆豪杰
    博士,研究员,博士生导师
    地址:东安路131号,明道楼311室,上海 200032 
    电话:021-54237618
    传真:021-54237961
    邮箱:luhaojie@fudan.edu.cn
    蛋白质组精准鉴定搜索引擎及技术体系获批“蛋白质机器与生命过程调控”专项首席;获批经费:2337万
工作经历
教授,复旦大学,化学系,生物医学研究院(2008.9-至今)
副教授,复旦大学,化学系(2004.9-2008.7)
讲师,复旦大学,化学系(2003.9-2004.7)
访问学者,美国加州大学洛杉矶分校(UCLA)医学院(2006.9-2007.9)
博士后,中科院上海有机化学研究所(2001.9-2003.7)
教育经历
博士,中科院兰州化物所(1996-2001)
学士,厦门大学,化学系(1992-1996)
所获人才项目
万人计划——领军人才,中组部,2016
创新人才推进计划,科技部,2014
东方学者——跟踪计划,上海市教委,2013
上海市优秀学术带头人,上海市科委,2011
国家杰出青年科学基金,国家自然科学基金,2010
东方学者,上海市教委,2009
曙光学者,上海市教委,2008
新世纪优秀人才,教育部,2006
所获奖项
自然科学二等奖(第二),教育部,2014
上海市科学技术三等奖(第二),上海市科协,2014
青年化学奖,中国化学会,2009
自然科学提名一等奖(第四),教育部,2005
研究方向
课题组研究兴趣是基于生物质谱的蛋白质组学新技术新方法建立与应用研究。与疾病相关的蛋白质往往是丰度较低的蛋白质并和蛋白质翻译后修饰有关,这些重要的蛋白质由于本身存在的量极少或修饰的量极少而很难得以有效鉴定。低丰度蛋白质和蛋白质翻译后修饰的精准质谱定性和定量分析作为一个艰巨的前沿研究任务,适合质谱鉴定的样品处理方法和相应的质谱分析方法对实现该任务起着首要和关键作用。课题组建立了一系列复杂背景干扰下低丰度蛋白质和翻译后修饰蛋白质的高灵敏鉴定和高准确定量新方法,在重大疾病蛋白质标志物高灵敏鉴定和高准确验证关键环节获系列重要成果。
课题组长陆豪杰主持包括国家重点研发计划、国家自然基金重点项目和S973课题等在内的国家及省部级项目十余项,在包括Nat Immun, Nature Commun,Angew Chem Int Ed,Mol Cell Proteomics,Anal Chem,J Proteome Res等在内的学术期刊上发表SCI论文168篇,被引2900余次,在以第一和通讯作者发表的104篇SCI论文中,有29篇的同年同领域引用率排名前20%,其中有2篇排名前1%,14篇排名前10%。在质谱分析和蛋白质组学研究领域应邀撰写多篇综述,包括发表在Anal Bioanal Chem(2010), Anal Meth(2012), Glycoconjugate J(2012), Clin Proteomics(2014),以及Chem Soc Rev (2015)等。授权中国发明专利9项。
代表论文
  1. Yuan, W., Zhang, Y., Xiong, Y., Tao, T., Wang, Y., Yao, J., Zhang, L., Yan, G., Bao, H., Lu, H.* (2017) Highly Selective and Large Scale Mass Spectrometric Analysis of 4-Hydroxynonenal Modification via Fluorous Derivatization and Fluorous Solid-Phase Extraction. Analytical chemistry 89, 3093-3100.

  2. Xiong, Y., Zhang, Y., Yao, J., Yan, G., Lu, H.* (2017) Direct digestion of living cells via a gel-based strategy for mass spectrometric analysis. Chemical communications (Cambridge, England) 53, 1421-1424.

  3. Li, L., Jiao, J., Cai, Y., Zhang, Y.*, Lu, H.* (2015) Fluorinated carbon tag derivatization combined with fluorous solid-phase extraction: a new method for the highly sensitive and selective mass spectrometric analysis of glycans. Analytical chemistry 87, 5125-5131.

  4. Liu, M., Fang, C., Pan, X., Jiang, H., Zhang, L., Zhang, L., Zhang, Y., Yang, P., Lu, H.* (2015) Positive enrichment of C-terminal peptides using oxazolone chemistry and biotinylation. Analytical chemistry 87, 9916-9922.

  5. Zhang, Y., Zhang, C., Jiang, H., Yang, P., Lu, H.* (2015b) Fishing the PTM proteome with chemical approaches using functional solid phases. Chemical Society reviews 44, 8260-8287.

  6. Zhang, L., Jiang, H., Yao, J., Wang, Y., Fang, C., Yang, P., Lu, H.* (2014a) Highly specific enrichment of N-linked glycopeptides based on hydrazide functionalized soluble nanopolymers. Chemical communications (Cambridge, England) 50, 1027-1029.

  7. Zhang, Y., Kuang, M., Zhang, L., Yang, P., Lu, H.* (2013a) An accessible protocol for solid-phase extraction of N-linked glycopeptides through reductive amination by amine-functionalized magnetic nanoparticles. Analytical chemistry 85, 5535-5541.

  8. Liu, M., Zhang, L., Zhang, L., Yao, J., Yang, P., Lu, H.* (2013) Approach for identification and quantification of C-terminal peptides: incorporation of isotopic arginine labeling based on oxazolone chemistry. Analytical chemistry 85, 10745-10753.

  9. Wang, D., Fang, C., Zong, N., Liem, D., Cadeiras, M., Scruggs, S., Yu, H., Kim, A., Yang, P., Deng, M., Lu, H.*, Ping, P.* (2013) Regulation of acetylation restores proteolytic function of diseased myocardium in mouse and human. Molecular & cellular proteomics 12, 1-8.

  10. Ma, W., Zhang, Y., Li, L., You, L., Zhang, P., Zhang, Y., Li, J., Yu, M., Guo, J., Lu, H.*, Wang, C.* (2012) Tailor-Made Magnetic Fe3O4@mTiO2 Microspheres with a Tunable Mesoporous Anatase Shell for Highly Selective and Effective Enrichment of Phosphopeptides. ACS nano 6, 3179.

  11. Xiong, H., Guan, X., Jin, L., Shen, W., Lu, H.*, Xia, Y.* (2008) Surfactant-free synthesis of SnO2@PMMA and TiO2@PMMA core-shell nanobeads designed for peptide/protein enrichment and MALDI-TOF MS analysis. Angewandte Chemie (International ed in English) 47, 4204-4207.

  12. Lu, H., Zong, C., Wang, Y., Young, G., Deng, N., Souda, P., Li, X., Whitelegge, J., Drews, O., Yang, P., Ping, P*. (2008) Revealing the dynamics of the 20 S proteasome phosphoproteome: a combined CID and electron transfer dissociation approach. Molecular & cellular proteomics : MCP 7, 2073-2089.

  13. Xu, Y., Zhang, L., Lu, H.*, Yang, P. (2008) Mass spectrometry analysis of phosphopeptides after peptide carboxy group derivatization. Analytical chemistry 80, 8324-8328.

  14. Shen, W., Xiong, H., Xu, Y., Cai, S., Lu, H.*, Yang, P. (2008) ZnO-poly(methyl methacrylate) nanobeads for enriching and desalting low-abundant proteins followed by directly MALDI-TOF MS analysis. Analytical chemistry 80, 6758-6763.

  15. Jia, W., Chen, X., Lu, H.*, Yang, P.* (2006) CaCO3-poly(methyl methacrylate) nanoparticles for fast enrichment of low-abundance peptides followed by CaCO3-core removal for MALDI-TOF MS analysis. Angewandte Chemie (International ed in English) 45, 3345-3349.

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