长江学者
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  • 邹云增

    上海市心血管病研究所副所长,复旦大学附属中山医院临床研究院副院长、心实验室主任、心内科教授,博士生导师
    地址:东安路131号,明道楼603室,上海 200032
    电话:021-54237969(办公室)
    传真:021-54237969
    邮箱:zou.yunzeng@zs-hospital.sh.cn

工作经历
教授,复旦大学,附属中山医院心内科(2004.9-今)
教授,复旦大学, 生物医学研究院(2005,6-至今)
研究员,东京大学医学部心内科和千叶大学医学部心内科(2000.4-2004.8)
博士后,东京大学医学部心内科(1993.4-1997.3)
主治医师,青岛医学院附属医院心内科(1984.9-1993.3)
教育经历
博士,日本东京大学医学部心内科(1993.4-1997.3)
学士,北京医学院医学系(1979.9-1984.8)
所获人才项目
长江学者特聘教授,教育部,2005
国家杰出青年科学基金,国家自然科学基金,2006
上海市优秀学术带头人,上海市科委,2005
上海市领军人才,上海市,2014
所获奖项
上海市侨界十大杰出人物,上海市政府,2015
华夏医学三等奖,健康促进会,2014
中华医学会科技三等奖,中华医学会,2014
上海市科技进步一等奖,上海科协,2014
教育部科技进步二等奖,教育部,2014
上海市十大科技精英,上海市政府,2013
上海市医学科技二等奖,上海医学会,2012
研究方向
研究方向是心血管内科学,主要是高血压性心肌肥厚、心力衰竭、心肌再生的研究,主持和参与多项国家项目,包括国家自然科学基金重点项目、重大国际合作项目、创新研究群体项目、“973”项目和上海市科委项目等。在国外杂志包括Nat Cell Biol, Nature, Nat Med, Circulation, Circ Res, J Biol Chem, Hypertension等杂志上发表了200余篇SCI收录学术论文。 兼任中国医师协会心力衰竭专业委员会副主任委员、中华医学会心血管病学专业委员会基础研究学组副组长等。
代表论文
  1. Gao W, Yuan J, Liu H, Wu C, Huang D, Zhu J, Guo J, Ma L, Shi H, Zou Y, Ge J. Dendritic cells derived exosomes migration to spleen and induction of inflammation are regulated by CCR7. Sci Rep. 2017 Feb 22;7:42996.

  2. Wo D, Peng J, Ren DN, Qiu L, Chen J, Zhu Y, Yan Y, Yan H, Wu J, Ma E, Zhong TP, Chen Y, Liu Z, Liu S, Ao L, Liu Z, Jiang C, Peng J, Zou Y, Qian Q, Zhu W.Opposing Roles of Wnt Inhibitors IGFBP-4 and Dkk1 in Cardiac Ischemia by Differential Targeting of LRP5/6 and β-catenin. Circulation. 2016 Dec 13;134(24):1991-2007.

  3. Gao W, Liu H, Yuan J, Wu C, Huang D, Ma Y, Zhu J, Ma L, Guo J, Shi H, Zou Y, Ge J. Exosomes derived from mature dendritic cells increase endothelial inflammation and atherosclerosis via membrane TNF-α mediated NF-κB pathway. J Cell Mol Med. 2016 Dec;20(12):2318-2327.

  4. Sun Y, Kang L, Li J, Liu H, Wang Y, Wang C, Zou Y. Advanced glycation end products impair the functions of saphenous vein but not thoracic artery smooth muscle cells through RAGE/MAPK signalling pathway in diabetes. J Cell Mol Med. 2016 Oct;20(10):1945-55.

  5. Wang X, Ye Y, Gong H, Wu J, Yuan J, Wang S, Yin P, Ding Z, Kang L, Jiang Q,Zhang W, Li Y, Ge J, Zou Y. The effects of different angiotensin II type 1 receptor blockers on the regulation of the ACE-AngII-AT1 and ACE2-Ang(1-7)-Masaxes in pressure overload-induced cardiac remodeling in male mice. J Mol Cell Cardiol. 2016 Aug;97:180-90.

  6. Liu H, Gao W, Yuan J, Wu C, Huang D, Ma Y, Zhu J, Ma L, Guo J, Shi H, Zou Y, Ge J. Exosomes derived from mature dendritic cells increase endothelial inflammation and atherosclerosis via membrane TNF-α mediated NF-κB pathway. J Cell Mol Med. 2016;20(12):2318-2327.

  7. Liu H, Gao W, Yuan J, Wu C, Yao K, Zhang L, Ma L, Zhu J, Zou Y, Ge J. Exosomes derived from dendritic cells improve cardiac function via activation of CD4(+) T  lymphocytes after myocardial infarction. J Mol Cell Cardiol. 2016 Feb;91:123-33.

  8. Lin L, Liu X, Xu J, Weng L, Ren J, Ge J, Zou Y. Mas receptor mediatescardioprotection of angiotensin-(1-7) against Angiotensin II-induced cardiomyocyte autophagy and cardiac remodelling through inhibition of oxidative stress. J Cell Mol Med. 2016 Jan;20(1):48-57.

  9. Lin L, Liu X, Xu J, Weng L, Ren J, Ge J, Zou Y. High-density lipoprotein inhibits mechanical stress-induced cardiomyocyte autophagy and cardiac hypertrophy through angiotensin II type 1 receptor-mediated PI3K/Akt pathway. J Cell Mol Med. 2015 Aug;19(8):1929-38.

  10. Wu J, You J, Wang S, Ye Y, Wang X, Jia J, Zou Y. Letter to the editor: When what you see might not be what you get: prudent considerations of anesthetics for murine echocardiography. Am J Physiol Heart Circ Physiol. 2015 Jun 15;308(12):H1612-3.

  11. Ye Y, Gong H, Wang X, Wu J, Wang S, Yuan J, Yin P, Jiang G, Li Y, Ding Z,Zhang W, Zhou J, Ge J, Zou Y. Combination Treatment With Antihypertensive Agents Enhances the Effect of Qiliqiangxin on Chronic Pressure Overload-induced Cardiac Hypertrophy and Remodeling in Male Mice. J Cardiovasc Pharmacol. 2015 Jun;65(6):628-39.

  12. Jiang G, Gong H, Niu Y, Yang C, Wang S, Chen Z, Ye Y, Zhou N, Zhang G, Ge J, Zou Y. Identification of Amino Acid Residues in Angiotensin II Type 1 Receptor Sensing Mechanical Stretch and Function in Cardiomyocyte Hypertrophy. Cell Physiol Biochem. 2015;37(1):105-16.

  13. Sun A, Zou Y, Wang P, Xu D, Gong H, Wang S, Qin Y, Zhang P, Chen Y, Harada M, Isse T, Kawamoto T, Fan H, Yang P, Akazawa H, Nagai T, Takano H, Ping P, Komuro I, Ge J. Mitochondrial aldehyde dehydrogenase 2 plays protective roles in heart failure after myocardial infarction via suppression of the cytosolic JNK/p53 pathway in mice. J Am Heart Assoc. 2014.Oct;3(5):e000779-e000779

  14. Gong H, Yan Y, Fang B, Xue Y, Yin P, Li L, Zhang G, Sun X, Chen Z, Ma H, Yang C, Ding Y, Yong Y, Zhu Y, Yang H, Komuro I, Ge J, Zou Y. Knockdown of nucleosome assembly protein 1-like 1 induces mesoderm formation and cardiomyogenesis via notch signaling in murine-induced pluripotent stem cells. Stem Cells. 2014 Jul;32(7):1759-73.

  15. Chen Z, Xu J, Ye Y, Li Y, Gong H, Zhang G, Wu J, Jia J, Liu M, Chen Y, Yang C, Tang Y, Zhu Y, Ge J, Zou Y. Urotensin II inhibited the proliferation of cardiac side population cells in mice during pressure overload by JNK-LRP6 signalling. J Cell Mol Med. 2014 May;18(5):852-62.

  16. Wang S, Gong H, Jiang G, Ye Y, Wu J, You J, Zhang G, Sun A, Komuro I, Ge J,Zou Y. Src is required for mechanical stretch-induced cardiomyocyte hypertrophy through angiotensin II type 1 receptor-dependent β-arrestin2 pathways. PLoS One. 2014 Apr 3;9(4):e92926.

  17. Lin L, Tang C, Xu J, Ye Y, Weng L, Wei W, Ge J, Liu X, Zou Y. Mechanical stress triggers cardiomyocyte autophagy through angiotensin II type 1 receptor-mediated p38MAP kinase independently of angiotensin II. PLoS One. 2014 Feb 21;9(2):e89629.

  18. Guan A, Gong H, Ye Y, Jia J, Zhang G, Li B, Yang C, Qian S, Sun A, Chen R, Ge J, Zou Y. Regulation of p53 by jagged1 contributes to angiotensin II-induced impairment of myocardial angiogenesis. PLoS One. 2013 Oct 3;8(10):e76529.

  19. Wu C, Zhang Y, Gong Y, Hou Y, Li S, Zou Y, Ge J. Two cases of bacterial suppurative thyroiditis caused by Streptococcus anginosus. Endocr Pathol. 2013 Mar;24(1):49-53.

  20. Wu C, Gong Y, Sun A, Zhang Y, Zhang C, Zhang W, Zhao G, Zou Y, Ge J. The human MTHFR rs4846049 polymorphism increases coronary heart disease risk through  modifying miRNA binding. Nutr Metab Cardiovasc Dis. 2013 Jul;23(7):693-8.

  21. You J, Wu J, Ge J, Zou Y. Comparison between adenosine and isoflurane for assessing the coronary flow reserve in mouse models of left ventricular pressure and volume overload. Am J Physiol Heart Circ Physiol. 2012 Nov 15;303(10):H1199-207.

  22. Wang S, Sun A, Li L, Zhao G, Jia J, Wang K, Ge J, Zou Y. Up-regulation of BMP-2 antagonizes TGF-β1/ROCK-enhanced cardiac fibrotic signalling through activation of Smurf1/Smad6 complex. J Cell Mol Med. 2012 Oct;16(10):2301-10.

  23. Zhang W, Du Q, Li H, Sun A, Qiu Z, Wu C, Zhao G, Gong H, Hu K, Zou Y, Ge J. The therapeutic effect of Rosuvastatin on cardiac remodeling from hypertrophy to fibrosis during the end-stage hypertension in rats,J Cell Mol Med. 2012 Sep;16(9):2227-2237

  24. Ma H, Gong H, Chen Z, Liang Y, Yuan J, Zhang G, Wu J, Ye Y, Yang C, Nakai A, Komuro I, Ge J, Zou Y. Association of Stat3 with HSF1 plays a critical role in G-CSF-induced cardio-protection against ischemia/reperfusion injury. J Mol Cell Cardiol. 2012 Jun;52(6):1282-90.

  25. Zou Y, Liang Y, Gong H, Zhou N, Ma H, Guan A, Sun A, Wang P, Niu Y, Jiang H, Takano H, Toko H, Yao A, Takeshima H, Akazawa H, Shiojima I, Wang Y, Komuro I, Ge J. Ryanodine receptor type 2 is required for the development of pressure overload-induced cardiac hypertrophy. Hypertension. 2011 Dec;58(6):1099-110.

  26. Zou Y, Li J, Ma H, Jiang H, Yuan J, Gong H, Liang Y, Guan A, Wu J, Li L, Zhou N, Niu Y, Sun A, Nakai A, Wang P, Takano H, Komuro I, Ge J. Heat shock transcription factor 1 protects heart after pressure overload through promoting myocardial angiogenesis in male mice. J Mol Cell Cardiol. 2011 Nov;51(5):821-9.

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