课题组长
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  • 管坤良

    博士,教授,博士生导师
    地址:东安路131号,明道楼801室,上海 200032
    电话:021-5423853(办公室),021-54237832(实验室)
    传真:021-54237450
    邮箱:kuguan@ucsd.edu
    实验室主页:http://www.mcb.fudan.edu.cn

工作经历
教授,美国加州大学圣地亚哥分校(UCSD),药理系(2007-今)
杰出教授,美国加州大学圣地亚哥分校(UCSD),药理系(2013-今)
兼职教授,浙江大学,生命科学研究院(2009-今)
兼职教授,美国密歇根大学(University of Michigan),生物化学系(2007-2012)
兼职教授,复旦大学,生物医学研究院(2005-今)
研究教授,美国密歇根大学(University of Michigan),生命科学院(2003-2007)
Halvor N. Christensen Collegiate 教授,美国密歇根大学(University of Michigan),生命科学院(2003-2007)
教授,美国密歇根大学(University of Michigan),生物化学系(2000-2007)
客座教授,美国科罗拉多大学博尔德分校,化学与生物化学系(2002)
副教授,美国密歇根大学(University of Michigan),生物化学系(1996-2000)
助理教授,美国密歇根大学(University of Michigan),生物化学系(1992-1996)
博士后,美国普渡大学(Purdue University),生物化学(1989-1991)
教育经历
博士,美国普渡大学(Purdue University),生物化学(1983-1989)
学士,杭州大学,生物学(1978-1982)
所获人才项目
国家杰出青年科学基金B类,国家自然科学基金,1996
长江学者奖励计划讲座教授,教育部,2007
所获奖项
马克兄弟奖,印第安那大学医学院,2015
分子生物学与遗传学领域高被引科学家(2002-2012),汤森路透,2014
吴瑞奖,华人生物学家协会,2011
美国科学促进会会士(AAAS fellow),美国科学促进会,2011
杰出校友奖,普渡大学农学院,2006
教师认可奖Faculty Recognition Award,密歇根大学,2004
青年研究者奖,华人生物科学学会,1999
青年研究者奖,美国生物化学与分子生物学学会,1999
麦克阿瑟奖,麦克阿瑟基金会,1998-2003
The Arnold Kent Balls奖,普渡大学,1989
研究方向
乙酰化对代谢的调控
主要集中在探讨乙酰化对代谢酶调控的分子机制,及乙酰化对代谢酶调控异常与人类代谢疾病发生发展的相关性。
代谢基因突变与肿瘤发生
集中于探讨IDH通道的功能,代谢物如何调控基因表达和表观遗传修饰,及基于IDH通道的抗肿瘤药物开发。
迄今为止,已在国内外学术刊物上发表论文300多篇,引用次数高达40000多次, H-index>100。
代表论文
  1. Yuan,H-X., Wang, Z., Yu, F-X., Li, F-L., Russell, RC., Jewell, JL., and Guan, K-L.,(2015)NLK phosphorylates Raptor to mediate stress-induced mTORC1 inhibition. Genes Dev.29: 2362-2376.

  2. Yu, F.X., Zhao, B., and Guan, K-L. (2015) Hippo pathway in organ size control, tissue homeostasis, and cancer. Cell 163, 811-828.

  3. Zhou, X., Wang, S-Y., Wang, Z., Feng, X., Liu, P., Lv, X-B., Li, F-L., Yu, F-x., Sun,Y-P., Yuan, H-X., Zhu,H-G., Xiong,Y., Lei, Q-Y., Guan, K-L.(2015). Estrogen Activates TAZ via GPER in Invasive Ductal Breast Carcinoma. J Clin Invest. 125(5):2123-35.

  4. Zha, Z-Y., Han, X-R., Matthew D. Smith, Liu, Y., Patrick M. Giguère, Dragana Kopanja, Pradip Raychaudhuri, David P. Siderovski, Guan, K-L., Lei, Q-Y., and Xiong, Y., (2015) A non-canonical function of Gβ as a subunit of E3 ligase in targeting GRK2 ubiquitylation. Mol Cell.58(5):794-803.

  5. Wang, Y-P., Xiao M-T., Chen, X-F., Chen, L-L., Xu, Y-P., Lv,L., Wang, P., Yang, H., Ma, S-H., Lin, H-P., Jiao, B., Ren, R-B., Ye, D*., Guan, K-L* ., and Xiong, Y*., (2015) WT1 recruits TET2 to regulate its target gene expression and suppress leukemia cell proliferation. Mol Cell.57, 1–12.

  6. Zhao, D., Mo, Y., Li, M-T., Zou ,S-W., Cheng, Z-L., Sun, Y-P., Xiong, Y*., Guan, K-L*., Lei, Q-Y*., (2014 )NOTCH-induced aldehyde dehydrogenase 1A1 deacetylation promotes breast cancer stem cells.J Clin Invest. 124(12):5453-65.

  7. Lv, L., Xu, Y-P., Zhao, D., Li, F-L., Wang, W., Sasaki N., Jiang, Y., Zhou, X., Li, T-T., Guan, K-L.,Lei, Q-Y.,and Xiong, Y.,(2013) Mitogenic and oncogenic stimulation of K433 acetylation promote PKM2 protein kinase activity and nuclear localization. Molecular Cell, 2013,52, 340–352

  8. Lin,R., Ren, T., Gao, X., Zhou, X., Li, T., Xiong, Y., Guan, K-L., Lei, Q-Y..(2013) Acetylation Stabilizes ATP-citrate Lyase to Promote Lipid Biosynthesis and Tumor Growth. Molecular Cell, 51, 506–518

  9. Zhao, D., Zou, S., Liu, Y., Zhou, X., Mo, Y., Wang, P., Xu, Y., Dong, B., Xiong, Y., Lei, Q-Y., and Guan K-L., (2013) Lysine-5 Acetylation Negatively Regulates Lactate Dehydrogenase A and Is Decreased in Pancreatic Cancer. Cancer Cell, 23, 464-476

  10. Xiao, H., Yang, H., Xu, W., Lin, H-P., Liu, Y., Zhu, H-G., Yang, C., Zhao, S., Ye, D., Xiong, X., and Guan, K-L. (2012) Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that accumulated in mutations of FH and SDH tumor suppressors. Genes & Development26(12): 1326-1338

  11. Zhang, TF., Wang, SW., Lin, Y., Xu, W., Xiong, Y., Zhao SM., and Guan, KL. (2012) Acetylation negatively regulates glycogen phosphorylase by recruiting protein phosphatase 1. Cell Metabolism, 15(1):75-87

  12. Jiang, WQ., Wang, SW., Xiao, MT., Lin,Y., Lei, QY., Xiong, Y., Guan, KL., and Zhao,SM. (2011) Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase. Molecular Cell, 43:33-44.

  13. Lv, L., Li, D., Zhao, D., Lin, RT. Zhang, H., Zha, ZY., Xu, YP., Li, Z., Huang, YR., Zhao, SM., Xiong, Y., Guan, K-L., Lei, Q-Y., (2011) Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth. Molecular Cell, 42:719-730.

  14. Xu,W., Yang,H., Liu,Y., Yang,Y., Wang,P., Kim,S-H., Ito S., Yang,C., Wang,P., Xiao,M-T., Liu,L-X., Jiang,W-Q., Liu,J.,Zhang, J-Y., Wang, B., Frye,S., Zhang,Y., Xu,Y-H., Lei, Q-Y., Guan,K-L., Zhao,S-M., and Xiong,Y., (2011) Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell, 19:17-30.

  15. Zhao,S-M., Xu,W., Jiang,W-Q., Yu,W., Lin,Y., Zhang,T-F., Yao,J.,Yang,P-Y., Li,H., Li,Y-X.,Shi,J., Qin,L-X., Lei,Q-Y., Xiong,Y., Guan,K-L., (2010) Protein acetylation plays an extensive role in regulating cellular metabolism. Science, 327:1000-1004

  16. Zhao, S-M., Xu, W., Jiang, W-Q., Zha, Z-Y., Wang, P., Li, Z-Q., Gong, L-L., Peng, Y-J., Ding, J-P., Lei, Q-Y., Guan, K-L., Xiong, Y., (2009) Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1a. Science, 324:261-265

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