课题组长
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  • 叶定伟

    副院长,泌尿男生殖系统肿瘤多学科协作诊治中心首席专家,主任医师、博导、现任复旦大学附属肿瘤医院试验研究中心和复旦大学生物科学院(IBS)双聘PI
    地址:东安路 270 号,上海 200032
    电话:021-64175590*81807 (办公室)
    传真:021-64438640
    邮箱:dwyeli@163.com

工作经历
1986.7―2002.5,第二军医大学附属长海医院泌尿外科(历任住院医师、主治医师、副主任医师、副教授、硕士研究生导师)
1996.9―1998.12,美国MD Anderson Cancer Center (访问学者、博士后)
2002.5―至今,复旦大学附属肿瘤医院(历任泌尿外科科主任、主任医师、教授、博士生导师)
2007.10―至今,复旦大学附属肿瘤医院副院长
教育经历
1981-09至1986-07,第二军医大学军医系,大学生
1990-09至1993-07,第二军医大学外科学系泌尿外科专业,硕士生
1997-09至2000-07,第二军医大学外科学系泌尿外科专业,博士生
所获人才项目
国家卫计委有突出贡献中青年专家,国家卫计委,2015
国务院特殊津贴,国务院,2013
上海领军人才,中共上海市委组织部,2011
上海医学领军人才,上海市卫生局,2011
恩德思医学科学技术奖杰出成就奖,恩德思医学科学技术奖评奖委员会,2011
复旦大学优秀人才院长奖金奖,复旦大学上海医学院,2010
上海市优秀学科带头人A类计划,上海市科委,2009
吴阶平泌尿外科医学奖,吴阶平泌尿外科医学基金会,1996
所获奖项
中国抗癌协会科技奖二等奖(第一完成人),中国抗癌协会,2016
上海市优秀发明选拔赛优秀发明金奖,上海市总工会,2016
国家科技进步一等奖(第三完成人),国务院,2012
上海市科技进步奖一等奖(第一完成人),上海市,2012
教育部科技进步奖二等奖(第一完成人),教育部,2012
上海市医学会科技奖一等奖(第一完成人),上海市医学会,2012
上海市科技进步一等奖(第一完成人),上海市,2010
中国抗癌协会科技奖二等奖(第一完成人),中国抗癌协会,2010
中华医学科技进步奖二等奖(第一完成人),中华医学会,2010
高等学校科技进步奖一等奖(第一完成人),教育部,2010
上海医学科技奖二等奖(第一完成人),上海市医学会,2010
研究方向
课题组利用分子生物学、免疫学及生物信息学等方法研究包括前列腺癌、肾癌、膀胱癌和阴茎癌在内的泌尿男生殖系统肿瘤信号转导、肿瘤微环境、肿瘤代谢及表观遗传学调控机制,构建相关分子预后及预测模型,并探索其转化医学意义。我们过去研究了前列腺癌AR相关信号通路,DNA甲基化在CRPC中的改变,以及miRNA在前列腺癌骨转移中的作用机制,并构建了一系列可用于临床的分子模型。我们目前正在进行肿瘤微环境,肿瘤代谢和表观遗传学等机制研究。希望揭示这些复杂的调控网络与肿瘤之间的关系,为寻找新的治疗靶点提供依据。
课题组组长叶定伟教授牵头国家、上海市、吴阶平医学基金会前列腺癌重点基础研究项目多项,临床试验20余项。以通讯作者或第一作者发表SCI论文180余篇,包括Nature genetics,Molecular Cell,Clinical Cancer research,Oncogene等。
代表论文
  1. Ye, D., Mendelsohn, J., and Fan, Z. (1999) Androgen and epidermal growth factor down-regulate cyclin-dependent kinase inhibitor p27Kip1 and costimulate proliferation of MDA PCa 2a and MDA PCa 2b prostate cancer cells. Clinical cancer research : an official journal of the American Association for Cancer Research 5, 2171-2177

  2. Ye, D., Mendelsohn, J., and Fan, Z. (1999) Augmentation of a humanized anti-HER2 mAb 4D5 induced growth inhibition by a human-mouse chimeric anti-EGF receptor mAb C225. Oncogene 18, 731-738

  3. Dai, B., Ye, D. W., Kong, Y. Y., Yao, X. D., Zhang, H. L., and Shen, Y. J. (2006) Predicting regional lymph node metastasis in Chinese patients with penile squamous cell carcinoma: the role of histopathological classification, tumor stage and depth of invasion. The Journal of urology 176, 1431-1435; discussion 1435

  4. Zhu, Y., Zhou, X. Y., Yao, X. D., Dai, B., and Ye, D. W. (2007) The prognostic significance of p53, Ki-67, epithelial cadherin and matrix metalloproteinase-9 in penile squamous cell carcinoma treated with surgery. BJU international 100, 204-208

  5. Cao, D. L., Ye, D. W., Zhang, H. L., Zhu, Y., Wang, Y. X., and Yao, X. D. (2011) A multiplex model of combining gene-based, protein-based, and metabolite-based with positive and negative markers in urine for the early diagnosis of prostate cancer. The Prostate 71, 700-710

  6. Xu, J., Mo, Z., Ye, D., Wang, M., Liu, F., Jin, G., Xu, C., Wang, X., Shao, Q., Chen, Z., Tao, Z., Qi, J., Zhou, F., Wang, Z., Fu, Y., He, D., Wei, Q., Guo, J., Wu, D., Gao, X., Yuan, J., Wang, G., Xu, Y., Wang, G., Yao, H., Dong, P., Jiao, Y., Shen, M., Yang, J., Ou-Yang, J., Jiang, H., Zhu, Y., Ren, S., Zhang, Z., Yin, C., Gao, X., Dai, B., Hu, Z., Yang, Y., Wu, Q., Chen, H., Peng, P., Zheng, Y., Zheng, X., Xiang, Y., Long, J., Gong, J., Na, R., Lin, X., Yu, H., Wang, Z., Tao, S., Feng, J., Sun, J., Liu, W., Hsing, A., Rao, J., Ding, Q., Wiklund, F., Gronberg, H., Shu, X. O., Zheng, W., Shen, H., Jin, L., Shi, R., Lu, D., Zhang, X., Sun, J., Zheng, S. L., and Sun, Y. (2012) Genome-wide association study in Chinese men identifies two new prostate cancer risk loci at 9q31.2 and 19q13.4. Nature genetics 44, 1231-1235

  7. Ye, L., Li, S., Ye, D., Yang, D., Yue, F., Guo, Y., Chen, X., Chen, F., Zhang, J., and Song, X. (2013) Livin expression may be regulated by miR-198 in human prostate cancer cell lines. European journal of cancer (Oxford, England : 1990) 49, 734-740

  8. Zhu, Y., Zhou, X. Y., Yao, X. D., Zhang, S. L., Dai, B., Zhang, H. L., Shen, Y. J., and Ye, D. W. (2013) Prognostic value of carbonic anhydrase IX expression in penile squamous cell carcinoma: a pilot study. Urologic oncology 31, 706-711

  9. Zhu, Y., and Ye, D. W. (2014) Prostate cancer: alkaline phosphatase velocity in nonmetastatic CRPC. Nature reviews. Urology 11, 666-667

  10. Gu, W., Zhang, G., Sun, L., Ma, Q., Cheng, Y., Zhang, H., Shi, G., Zhu, Y., and Ye, D. (2015) Nutritional screening is strongly associated with overall survival in patients treated with targeted agents for metastatic renal cell carcinoma. Journal of cachexia, sarcopenia and muscle 6, 222-230

  11. Li, F., He, X., Ye, D., Lin, Y., Yu, H., Yao, C., Huang, L., Zhang, J., Wang, F., Xu, S., Wu, X., Liu, L., Yang, C., Shi, J., He, X., Liu, J., Qu, Y., Guo, F., Zhao, J., Xu, W., and Zhao, S. (2015) NADP(+)-IDH Mutations Promote Hypersuccinylation that Impairs Mitochondria Respiration and Induces Apoptosis Resistance. Molecular cell 60, 661-675

  12. Li, Q., Gu, C., Zhu, Y., Wang, M., Yang, Y., Wang, J., Jin, L., Zhu, M. L., Shi, T. Y., He, J., Ye, D., and Wei, Q. (2015) Two novel PRKCI polymorphisms and prostate cancer risk in an Eastern Chinese Han population. Molecular carcinogenesis 54, 632-641

  13. Zhu, Y., Dai, B., Zhang, H., Shi, G., Shen, Y., and Ye, D. (2016) Long non-coding RNA LOC572558 inhibits bladder cancer cell proliferation and tumor growth by regulating the AKT-MDM2-p53 signaling axis. Cancer letters 380, 369-374

  14. Wan, F., Zhu, Y., Han, C., Xu, Q., Wu, J., Dai, B., Zhang, H., Shi, G., Gu, W., and Ye, D. (2017) Identification and validation of an eight-gene expression signature for predicting high Fuhrman grade renal cell carcinoma. International journal of cancer 140, 1199-1208

  15. Fu, H., Zhu, Y., Wang, Y., Liu, Z., Zhang, J., Wang, Z., Xie, H., Dai, B., Xu, J., and Ye, D. (2017) Tumor Infiltrating Mast Cells (TIMs) Confers a Marked Survival Advantage in Nonmetastatic Clear-Cell Renal Cell Carcinoma. Annals of surgical oncology 24, 1435-1442

  16. Tang, B., Han, C. T., Zhang, G. M., Zhang, C. Z., Yang, W. Y., Shen, Y., Vidal, A. C., Freedland, S. J., Zhu, Y., and Ye, D. W. (2017) Waist-hip Ratio (WHR), a Better Predictor for Prostate Cancer than Body Mass Index (BMI): Results from a Chinese Hospital-based Biopsy Cohort. Scientific reports 7, 43551

  17. Wang, Y., Dai, B., and Ye, D. W. (2017) Serum testosterone level predicts the effective time of androgen deprivation therapy in metastatic prostate cancer patients. Asian journal of andrology 19, 178-183

  18. Qu, Y., Gu, C., Wang, H., Chang, K., Yang, X., Zhou, X., Dai, B., Zhu, Y., Shi, G., Zhang, H., and Ye, D. (2016) Diagnosis of adults Xp11.2 translocation renal cell carcinoma by immunohistochemistry and FISH assays: clinicopathological data from ethnic Chinese population. Scientific reports 6, 21677

  19. Zhu, Y. P., Wan, F. N., Shen, Y. J., Wang, H. K., Zhang, G. M., and Ye, D. W. (2015) Reactive stroma component COL6A1 is upregulated in castration-resistant prostate cancer and promotes tumor growth. Oncotarget 6, 14488-14496

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