课题组长
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  • 孙爱军

    博士,研究员,博士生导师
    地址:斜土路1609号,19号楼203室,上海 200032
    电话:021-64041990
    传真:021-64223006
    邮箱:sun.aijun@zs-hospital.sh.cn

工作经历
兼职教授,美国德克萨斯A&M大学,健康科学中心,(2015.05-今)
访问学者,美国德克萨斯医学中心,医学院,(2014.08-2015.07)
博士生导师,复旦大学附属中山医院,上海市心血管病研究所,(2012.12-今)
研究员,复旦大学附属中山医院,上海市心血管病研究所,(2011.10-今)
双聘PI,复旦大学,生物医学研究院,(2009.05-今)
副研究员,复旦大学附属中山医院,上海市心血管病研究所(2005.05-2011.10)
访问学者,德国埃森大学,医学院,(2003.03-2004.05)
助理研究员,复旦大学附属中山医院,上海市心血管病研究所,(2002.08-2005.04)
教育经历
博士,上海交通大学,心内科,(1999-2002)
硕士,苏州大学,心内科,(1996-1999)
所获人才项目
新世纪优秀人才,教育部,2012
曙光学者,上海市教委,2009
启明星跟踪计划,上海市科委,2009
启明星项目,上海市科委,2006
所获奖项
科学技术进步奖推广类二等奖(第三完成人),教育部,2011
科学技术奖一等奖(第二完成人),上海市人民政府,2009
科学技术进步奖一等奖(第二完成人),教育部,2009
科学技术进步奖二等奖(第三完成人),教育部,2008
科技奖二等奖(第二完成人),中华医学会,2006
五洲女子科技奖(基础医学科研创新奖),中国女医师协会,2015
全国优秀科技工作者,中国科学技术协会,2014
上海市卫生系统银蛇奖,上海市卫生和计划生育委员会,2011
上海市十大青年科技英才(第五届),上海市科学技术协会,2010
研究方向
孙爱军教授长期致力于心力衰竭发病机制及转化研究,发现心脏钠通道基因突变通过线粒体功能失调直接损伤心肌;继之以乙醛脱氢酶2及线粒体代谢为切入点开展临床及基础研究,阐明了其通过维护代谢稳态发挥心肌保护、促进血运重建从而延缓心衰进展的新机制,提出了改善能量代谢储备及代谢微环境提高干细胞移植疗效的新思路,揭示了cheatocin通过干预线粒体代谢有望作为心衰治疗的新药物。研究成果获国家发明专利授权并完成临床转化。目前,课题组以心肌损伤与修复为主要研究方向,围绕各种病因导致的心力衰竭,拟通过基础、 临床、流行病学相结合的研究途径,探讨调控心衰发生发展的分子调控网络及作用机制,并从代谢角度遴选或修饰干细胞,探寻影响其移植疗效的关键因素,为心衰防治提供新靶点。
孙爱军教授以通讯或第一作者在Nat Commun、ATVB等发表SCI论文50余篇。总发表SCI论文被他引1541次。主持包括国家自然科学基金、国家“973”子课题等10余项基金,是国家基金委创新群体的主要成员。
代表论文
  1. Yang, G., X. Weng, Y. Zhao, X. Zhang, Y. Hu, X. Dai, P. Liang, P. Wang, L. Ma, X. Sun, L. Hou, H. Xu, M. Fang, Y. Li, T. Jenuwein, Y. Xu*, and A. Sun*. 2017. The histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction. Nat Commun. 8:14941.

  2. Wang, Y., X. Yan, S. Mi, Z. Li, Y. Wang, H. Zhu, X. Sun, B. Zhao, C. Zhao, Y. Zou, K. Hu, X. Ding*, A. Sun*, and J. Ge*. 2017. Naoxintong attenuates Ischaemia/reperfusion Injury through inhibiting NLRP3 inflammasome activation. J Cell Mol Med. 21:4-12.

  3. Shen, C., C. Wang, S. Han, Z. Wang, Z. Dong, X. Zhao, P. Wang, H. Zhu, X. Sun, X. Ma, H. Zhu*, Y. Zou, K. Hu, J. Ge*, and A. Sun*. 2016. Aldehyde dehydrogenase 2 deficiency negates chronic low-to-moderate alcohol consumption-induced cardioprotecion possibly via ROS-dependent apoptosis and RIP1/RIP3/MLKL-mediated necroptosis. Biochim Biophys Acta. pii: S0925-4439(16)30298-8.

  4. Liu, X., and A. Sun*. 2016. Aldehyde Dehydrogenase-2 Roles in Ischemic Cardiovascular Disease. Curr Drug Targets. [Epub ahead of print]

  5. Wang, C., F. Fan, Q. Cao, C. Shen, H. Zhu, P. Wang, X. Zhao, X. Sun, Z. Dong, X. Ma, X. Liu, S. Han, C. Wu, Y. Zou, K. Hu, J. Ge*, and A. Sun*. 2016. Mitochondrial aldehyde dehydrogenase 2 deficiency aggravates energy metabolism disturbance and diastolic dysfunction in diabetic mice. J Mol Med (Berl). 94:1229-1240.

  6. Xia, G., F. Fan, M. Liu, S. Wang, J. Wu, C. Shen, S. Han, C. Wang, J. Jia, Y. Zou, K. Hu, J. Ge*, and A. Sun*. 2016. Aldehyde dehydrogenase 2 deficiency blunts compensatory cardiac hypertrophy through modulating Akt phosphorylation early after transverse aorta constriction in mice. Biochim Biophys Acta. 1862:1587-93.

  7. Wang, P., L. Xu, and A. Sun*. 2016. Energy Remodeling, Mitochondrial Disorder and Heart Failure. Curr Pharm Des. 22:4823-4829.

  8. Wang, C., X. Li, C. Shen, L.L. Ma, Z. Dong, H. Zhu, P. Wang, J.B. Ge, and A. Sun*. 2016. SPECT imaging of cytochrome c in pressure overload mice hearts. RSC Advances. 6:88896-88896.

  9. Zhao, X., C. Shen, H. Zhu, C. Wang, X. Liu, X. Sun, S. Han, P. Wang, Z. Dong, X. Ma, K. Hu, A. Sun*, and J. Ge*. 2016. Trans-Fatty Acids Aggravate Obesity, Insulin Resistance and Hepatic Steatosis in C57BL/6 Mice, Possibly by Suppressing the IRS1 Dependent Pathway. Molecules. 21(6). pii: E705.

  10. Liu, X., X. Sun, H. Liao, Z. Dong, J. Zhao, H. Zhu, P. Wang, L. Shen, L. Xu, X. Ma, C. Shen, F. Fan, C. Wang, K. Hu, Y. Zou, J. Ge, J. Ren, and A. Sun*. 2015. Mitochondrial Aldehyde Dehydrogenase 2 Regulates Revascularization in Chronic Ischemia: Potential Impact on the Development of Coronary Collateral Circulation. Arterioscler Thromb Vasc Biol. 35:2196-206.

  11. Shen, C., C. Wang, F. Fan, Z. Yang, Q. Cao, X. Liu, X. Sun, X. Zhao, P. Wang, X. Ma, H. Zhu, Z. Dong, Y. Zou, K. Hu, A. Sun*, and J. Ge. 2015. Acetaldehyde dehydrogenase 2 (ALDH2) deficiency exacerbates pressure overload-induced cardiac dysfunction by inhibiting Beclin-1 dependent autophagy pathway. Biochim Biophys Acta. 1852:310-8.

  12. Wang, P., C. Shen, L. Diao, Z. Yang, F. Fan, C. Wang, X. Liu, X. Sun, Z. Dong, H. Zhu, X. Ma, Q. Cao, X. Zhao, D. Ma, Y. Zou, K. Hu, A. Sun*, and J. Ge*. 2015. Aberrant hypermethylation of aldehyde dehydrogenase 2 promoter upstream sequence in rats with experimental myocardial infarction. Biomed Res Int. 2015:503692.

  13. Zhu, H., A. Sun*, H. Zhu, Z. Li, Z. Huang, S. Zhang, X. Ma, Y. Zou, K. Hu, and J. Ge*. 2014. Aldehyde dehydrogenase-2 is a host factor required for effective bone marrow mesenchymal stem cell therapy. Arterioscler Thromb Vasc Biol. 34:894-901.

  14. Sun, A.*, Y. Cheng, Y. Zhang, Q. Zhang, S. Wang, S. Tian, Y. Zou, K. Hu, J. Ren, and J. Ge. 2014. Aldehyde dehydrogenase 2 ameliorates doxorubicin-induced myocardial dysfunction through detoxification of 4-HNE and suppression of autophagy. J Mol Cell Cardiol. 71:92-104.

  15. Sun, A.*, Y. Zou*, P. Wang, D. Xu, H. Gong, S. Wang, Y. Qin, P. Zhang, Y. Chen, M. Harada, T. Isse, T. Kawamoto, H. Fan, P. Yang, H. Akazawa, T. Nagai, H. Takano, P. Ping, I. Komuro*, and J. Ge*. 2014. Mitochondrial aldehyde dehydrogenase 2 plays protective roles in heart failure after myocardial infarction via suppression of the cytosolic JNK/p53 pathway in mice. J Am Heart Assoc. 3:e000779.

  16. Fan, F., Q. Cao, C. Wang, X. Ma, C. Shen, X. Liu, L. Bu, Y. Zou, K. Hu, A. Sun*, and J. Ge*. 2014. Impact of chronic low to moderate alcohol consumption on blood lipid and heart energy profile in acetaldehyde dehydrogenase 2-deficient mice. Acta Pharmacol Sin. 35:1015-22.

  17. Zhang, S., X. Ma, K. Yao, H. Zhu, Z. Huang, L. Shen, J. Qian, Y. Zou, A. Sun*, and J. Ge*. 2014. Combination of CD34-positive cell subsets with infarcted myocardium-like matrix stiffness: a potential solution to cell-based cardiac repair. J Cell Mol Med. 18:1236-8.

  18. Shen, C., L. Xu, Z. Yang, Y. Zou, K. Hu, Z. Fan, J. Ge, and A. Sun*. 2013. A1180V of cardiac sodium channel gene (SCN5A): is it a risk factor for dilated cardiomyopathy or just a common variant in Han Chinese? Dis Markers. 35:531-5.

  19. Zhao, J., H. Zhu, S. Wang, X. Ma, X. Liu, C. Wang, H. Zhao, S. Fan, X. Jin, B. Zhao, T. Zhao, L. Jia, K. Wang, Y. Zou, K. Hu, A. Sun*, and J. Ge*. 2013. Naoxintong protects against atherosclerosis through lipid-lowering and inhibiting maturation of dendritic cells in LDL receptor knockout mice fed a high-fat diet. Curr Pharm Des. 19:5891-6.

  20. Fan, F., A. Sun*, H. Zhao, X. Liu, W. Zhang, X. Jin, C. Wang, X. Ma, C. Shen, Y. Zou, K. Hu, and J. Ge*. 2013. MicroRNA-34a promotes cardiomyocyte apoptosis post myocardial infarction through down-regulating aldehyde dehydrogenase 2. Curr Pharm Des. 19:4865-73.

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