课题组长
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工作经历
研究员,复旦大学,化学系、生物医学研究院(2015.09-今)
博士后,瑞士洛桑联邦理工EPFL(2013.07-2015.08)
教育经历
博士,瑞士洛桑联邦理工EPFL,化学科学与工程(2009-2013)
硕士,复旦大学,化学生物学(2006-2009)
学士,复旦大学,化学系(2002-2006)
所获人才项目
青年千人,中组部,2015
所获奖项
瑞士质谱学会奖(学生),瑞士质谱学会,2013
优秀自费留学生奖,国家留学基金管理委员会,2012
研究方向
课题组主要集中在基于质谱的生命分析新方法、新技术研究,包括新型大气压原位离子化技术—静电喷雾离子化(ESTASI)、质谱数据解析新算法、微流控芯片-质谱联用技术。并将上述技术主要用于微生物鉴定、分型、耐药性研究;微生物与人源细胞相互作用研究;微生物代谢组研究;以及微生物基因蛋白质组研究。在微生物鉴定方面,我们开发了基于计算机模拟假设验证的谱图比对新算法,能够实现细菌株一级的精准鉴定、对混合细菌进行质谱鉴定,并收录了166个属、799种、2522株微生物的标准谱图库(bacteriams.fudan.edu.cn)。
课题组长乔亮主持和参与多项国家和省部级项目,包括国家重点研发计划、国家自然科学基金面上项目、上海市科委项目等。迄今为止,已在国内外学术刊物上发表论文54篇,包括JACS, Angewandte Chemie, Chemical Science, Analytical Chemistry等。
代表论文
  1. X. Bian, Y. Lan, B. Wang, Y.S. Zhang, B. Liu, P. Yang, W. Zhang*, L. Qiao*, Microfluidic air sampler for highly-efficient bacterial aerosol collection and identification, Analytical Chemistry, 88 (2016), 11504–11512

  2. X. Fang, J. Zhao, K. Zhang, P. Yang, L. Qiao*, and B. Liu*, Polydopamine Grafted Porous Graphene as Biocompatible Nanoreactor for Efficient Identification of Membrane Proteins, ACS applied materials & interfaces, 8 (2016), 6363–6370

  3. R. Du, L. Zhu, J. Gan, Y. Wang, L. Qiao*, and B. Liu*, Ultrasensitive Detection of Low-Abundant Protein by Mass Spectrometry Signal Amplification, Analytical Chemistry, 88 (2016), 6767–6772

  4. L. Qiao, E. Tobolkina, A. Lesch, A. Bondarenko, X. Zhong, B. Liu, H. Pick, H. Vogel, H. H. Girault, Electrostatic Spray Ionization Mass Spectrometry Imaging, Analytical Chemistry, 86 (2014), 2033-2041

  5. L. Qiao, E. Tobolkina, B. Liu, H. H. Girault, Coupling Isoelectric Focusing Gel Electrophoresis to Mass Spectrometry by Electrostatic Spray Ionization, Analytical Chemistry, 85 (2013), 4745-4752

  6. L. Qiao, R. Sartor, N. Gasilova, Y. Lu, E. Tobolkina, B. Liu, H. H. Girault, Electrostatic-Spray Ionization Mass Spectrometry, Analytical Chemistry, 84 (2012), 7422-7430

  7. M. Odijk, W. Olthuis, A. van den Berg, L. Qiao,* H. Girault, Improved Conversion Rates in Drug Screening Applications Using Miniaturized Electrochemical Cells with Frit Channels, Analytical Chemistry, 84 (2012), 9176-9183

  8. L. Qiao, Y. Lu, B. Liu, H. H. Girault, Copper-Catalyzed Tyrosine Nitration, Journal of the American Chemical Society, 133 (2011), 19823-19831

  9. L. Qiao, H. Bi, J. M. Busnel, M. Hojeij, M. Mendez, B. Liu, H. H. Girault, Controlling the specific enrichment of multi-phosphorylated peptides on oxide materials: Aluminium foil as a target plate for laser desorption ionization mass spectrometry, Chemical Science, 1 (2010), 374-382

  10. L. Qiao, C. Roussel, J. Wan, J. Kong, P. Yang, H. H. Girault, B. Liu, MALDI In‐Source Photooxidation Reactions for Online Peptide Tagging, Angewandte Chemie International Edition, 47 (2008), 2646-2648 (IF = 11.709) 10/21

 


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