课题组长
首页 > 人才队伍 > 课题组长
  • 李华伟

    教授,主任医师,博士生导师
    地址:汾阳路83号,上海 200031
    电话:021-64377134
    邮箱:hwli@shmu.edu.cn

工作经历
双聘PI,复旦大学,生物医学研究院(2008.01-今)
教授,主任医师,复旦大学附属眼耳鼻喉科医院(2004.05-今)
高级访问学者、研究员,哈佛大学医学院附属麻省眼耳医院(2002.01-2004.04)
副教授,复旦大学附属眼耳鼻喉科医院(1999.07-2001.12)
博士后,上海医科大学附属眼耳鼻喉科医院(1997.09-1999.06)
讲师,湖北医学院附属第一医院(1991.07-1994.08)
教育经历
博士,武汉同济医科大学,耳鼻喉科学(1994-1997)
硕士,湖北医学院,耳鼻喉科学(1988-1991)
所获人才项目
长江学者特聘教授,教育部,2007
973首席科学家,科技部,2011
国家杰出青年科学基金,国家自然科学基金,2005
教育部创新团队带头人,教育部,2011
国务院特殊津贴,国务院,2009
上海市优秀学术带头人,上海市科委,2011
上海市领军人才,上海市,2011
浦江人才计划,上海市科委,2005
所获奖项
国家科技进步二等奖(第二完成人),国务院,2005
自然科学一等奖(第一完成人),教育部,2008
上海科技进步一等奖(第三完成人),上海市政府,2010
中华医学科技三等奖(第一完成人),中华医学会,2011
研究方向
课题组围绕感音神经性耳聋发病机制和生物学干预策略展开系列的研究工作,主要的研究方向包括:1、感音神经性耳聋发病机制:遗传性耳聋致病基因的筛查和功能研究;噪音和药物等环境性致聋因素的致聋机制和易感基因的研究;各种因素导致毛细胞和螺旋神经节神经元损伤的分子机制研究;2、感音神经性耳聋的预防:利用斑马鱼和转基因小鼠模型,研究表观修饰和信号通路调控对受损毛细胞的保护作用,筛选具有临床药用价值的小分子化合物;3、感音神经性耳聋的生物学干预:研究内耳干细胞的生物学行为,通过多信号通路的细胞重编程技术激活内耳干细胞增殖促进毛细胞再生;建立高效安全的内耳病毒转染技术,探索基于重组腺相关病毒和CRISPR/Cas9系统的感音神经性耳聋基因治疗策略;探索有效的内耳给药途径,为相关临床研究奠定基础。4、基础研究成果向临床的转化研究:开发符合中国人群的耳聋基因诊断芯片,探索人工耳蜗植入的精准诊疗技术。
李华伟教授主持多项国家和省部级项目,包括国家重点基础研究发展计划(973项目,首席科学家)、国家杰出青年科学基金、国家自然科学基金重点项目、国家自然科学基金重大国际合作项目、面上项目、上海市科委项目等。迄今为止,在Nature Medicine、PNAS、J Neurosci、Trends in Molecular Medicine等国际著名期刊发表SCI收录论文60余篇(其中7篇论文获得封面照片和重点介绍的第一导读)。
代表论文
  1. Li W, Wu J, Yang J, Sun S, Chai R, Chen Z Y, and Li H* (2015). Notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathway. Proceedings of the National Academy of Sciences of the United States of America.112, 166-171.

  2. Ni W, Lin C, Guo L, Wu J, Chen Y, Chai R, Li W, and Li H* (2016). Extensive Supporting Cell Proliferation and Mitotic Hair Cell Generation by In Vivo Genetic Reprogramming in the Neonatal Mouse Cochlea. The Journal of neuroscience.36, 8734-8745.

  3. Li Y, Li A, Wu J, He Y, Yu H, Chai R, and Li H* (2016). MiR-182-5p protects inner ear hair cells from cisplatin-induced apoptosis by inhibiting FOXO3a. Cell death & disease.7, e2362.

  4. Ni W, Zeng S, Li W, Chen Y, Zhang S, Tang M, Sun S, Chai R, and Li H* (2016b). Wnt activation followed by Notch inhibition promotes mitotic hair cell regeneration in the postnatal mouse cochlea. Oncotarget.7, 66754-66768.

  5. He Y, Cai C, Sun S, Wang X, Li W, and Li H* (2016). Effect of JNK inhibitor SP600125 on hair cell regeneration in zebrafish (Danio rerio) larvae. Oncotarget.7, 51640-51650.

  6. Lu X, Sun S, Qi J, Li W, Liu L, Zhang Y, Chen Y, Zhang S, Wang L, Miao D, Chai R, and Li H* (2017). Bmi1 Regulates the Proliferation of Cochlear Supporting Cells Via the Canonical Wnt Signaling Pathway. Molecular neurobiology.54, 1326-1339.

  7. He Y, Tang D, Li W, Chai R, and Li H* (2016). Histone deacetylase 1 is required for the development of the zebrafish inner ear. Scientific reports.6, 16535.

  8. Tang D, Lin Q, He Y, Chai R, and Li H* (2016). Inhibition of H3K9me2 Reduces Hair Cell Regeneration after Hair Cell Loss in the Zebrafish Lateral Line by Down-Regulating the Wnt and Fgf Signaling Pathways. Frontiers in molecular neuroscience.9, 39.

  9. Liu L, Chen Y, Qi J, Zhang Y, He Y, Ni W, Li W, Zhang S, Sun S, Taketo M M, Wang L, Chai R, and Li H* (2016). Wnt activation protects against neomycin-induced hair cell damage in the mouse cochlea. Cell death & disease.7, e2136.

  10. He Y, Tang D, Cai C, Chai R, and Li H* (2016). LSD1 is Required for Hair Cell Regeneration in Zebrafish. Molecular neurobiology.53, 2421-2434.

  11. He Y, Wang Z, Sun S, Tang D, Li W, Chai R, and Li H* (2016). HDAC3 Is Required for Posterior Lateral Line Development in Zebrafish. Molecular neurobiology.53, 5103-5117.

  12. Sun S, Yu H, Yu H, Mei H, Ni W, Zhang Y, Guo L, He Y, Xue Z, Ni Y, Li J, Feng Y, Chen Y, Shao R, Chai R, and Li H* (2015). Inhibition of the Activation and Recruitment of Microglia-Like Cells Protects Against Neomycin-Induced Ototoxicity. Molecular neurobiology.51, 252-267.

  13. Chang Q, Wang J, Li Q, Kim Y, Zhou B, Wang Y, Li H*, and Lin X* (2015). Virally mediated Kcnq1 gene replacement therapy in the immature scala media restores hearing in a mouse model of human Jervell and Lange-Nielsen deafness syndrome. EMBO Molecular Medicine.7, 1077-1086.

  14. Gu X, Guo L, Ji H, Sun S, Chai R, Wang L, and Li H* (2015). Genetic testing for sporadic hearing loss using targeted massively parallel sequencing identifies 10 novel mutations. Clinical Genetics.87, 588-593.

  15. He Y, Yu H, Cai C, Sun S, Chai R, and Li H* (2015). Inhibition of H3K4me2 Demethylation Protects Auditory Hair Cells from Neomycin-Induced Apoptosis. Molecular neurobiology.52, 196-205.

  16. Mei H, Sun S, Bai Y, Chen Y, Chai R, and Li H* (2015). Reduced mtDNA copy number increases the sensitivity of tumor cells to chemotherapeutic drugs. Cell death & disease. 6, e1710.

  17. Chen Y, Li L, Ni W, Zhang Y, Sun S, Miao D, Chai R, and Li H* (2015). Bmi1 regulates auditory hair cell survival by maintaining redox balance. Cell death & disease.6.

  18. He Y, Mei H, Yu H, Sun S, Ni W, and Li H* (2014). Role of histone deacetylase activity in the developing lateral line neuromast of zebrafish larvae. Experimental and Molecular Medicine.46, e94.

  19. Yu H, Lin Q, Wang Y, He Y, Fu S, Jiang H, Yu Y, Sun S, Chen Y, Shou J, and Li H* (2013). Inhibition of H3K9 methyltransferases G9a/GLP prevents ototoxicity and ongoing hair cell death. Cell death & disease.4, e506

  20. Yan X, Wang X, Wang Z, Sun S, Chen G, He Y, Mo J Q, Li R, Jiang P, Lin Q, Sun M, Li W, Bai Y, Zhang J, Zhu Y, Lu J, Yan Q, Li H*, and Guan M-X* (2011). Maternally transmitted late-onset non-syndromic deafness is associated with the novel heteroplasmic T12201C mutation in the mitochondrial tRNA(His) gene. Journal of Medical Genetics.48, 682-690.

Top