课题组长
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  • 谭相石

    博士,教授,博士生导师
    地址:邯郸路220号,化学西楼330室,上海 2000433
    电话:021-55664475(办公室),021-65643973(实验室)
    传真:021-55664475
    邮箱:xstan@fudan.edu.cn

工作经历
教授、博士生导师,复旦大学,生物医学研究院/化学系(2007.9-至今)
Research Scientist,美国 Texas A &M University,化学系(2000.4-2007.8)
JSPS 研究员,日本 Ibaraki University, 理学部(1998.3-2000.3)
RCS 研究员,英国 Edinburgh University, 化学系(1997.10-1998.3)
博士后,法国 原子能委员会,CEA/Grenoble(1996.11-1997.10)
教育经历
博士,南京大学,配位化学研究所(1993-1996)
硕士,华东师范大学,化学系(1989-1992)
所获人才项目
浦江人才计划,上海市科委,2008
研究方向
研究领域属于化学生物学、生物化学、生物无机化学,课题组研究兴趣集中在生理与病理过程中的金属蛋白、金属酶的结构、功能、结构与功能的关系,金属中心结构对蛋白结构和功能的调控分子机制。研究基于金属蛋白、金属酶为靶点的药物设计和药理分子机制。具体研究方向包括:(1)基于天然免疫通路cGAS-cGAMP-STING-IRF3抗肿瘤药物的筛选以及免疫抗肿瘤药理分子机制研究;(2)基于免疫调节和金属内稳态调控的阿尔茨海默病药物及其药理分子机制研究;(3)以可溶性鸟苷酸环化酶(sGC)为中心的一氧化氮信号转导的结构基础和调控分子机制研究;(4)抗生素耐药病原体艰难梭菌(Clostridium difficile)代谢通路中金属蛋白、金属酶的结构、功能及其抑制剂药效、药理机制研究。
课题组获得多项国家自然科学基金委重大研究计划项目、面上项目和上海市科委人才计划项目等基金支持,发表国际SCI 学术论文近100篇,包括Nature,J Am Chem Soc., ChemComm, Scientific Reports, ChemBioChem等。
代表论文
  1. Pan J, Yuan H, Zhang X, Zhang H, Xu Q, Zhou Y, Tan L, Nagawa S, Huang ZX, Tan X*(2017)Probing the Molecular Mechanism of Human Soluble Guanylate Cyclase Activation by NO in vitro and in vivo. Scientific Reports, 7:43112.

  2. Li T, Cheng H, Yuan H, Xu Q, Shu C, Zhang Y, Xu P, Tan J, Rui Y, Li P, Tan X*(2016)Antitumor Activity of cGAMP via Stimulation of cGAS-cGAMP-STING-IRF3 Mediated Innate Immune Response. Scientific Reports, 6:19049.

  3. Pan J, Xu Q, Lin YW, Zhong F, Tan X.*(2013)Human soluble guanylate cyclase as a nitric oxide sensor for NO-signalling reveals a novel function of nitrite reductase. ChemComm, 49(67):7454-6.

  4. Luo Y, Wang D, Zhu C, Huang ZX, Tan X.*(2013)Exploring the differences between mouse mAβ (1-42) and human hAβ (1-42) for Alzheimer's disease related properties and neuronal cytotoxicity. ChemComm. 49(52):5865.

  5. Liu Y, Wang Q, Wei Y, Lin YW, Li W, Su JH, Wang Z, Tian Y, Huang ZX, Tan X.* (2013) Functional conversion of nickel-containing metalloproteins via molecular design: from a truncated acetyl-coenzyme A synthase to a nickel superoxide dismutase. ChemComm. 49(14):1452-4.

  6. Tan X. Martinho M, Stubna A, Lindahl PA, Münck E. (2008) Mossbauer evidence for an exchange-coupled {[Fe4S4]1+ Nip1+} A-cluster in isolated alpha subunits of acetyl-coenzyme A synthase/carbon monoxide dehydrogenase. J Am Chem Soc. 130(21):6712-3.

  7. Tan X. Surovtsev IV, Lindahl PA. (2006) Kinetics of CO insertion and acetyl group transfer steps, and a model of the acetyl-CoA synthase catalytic mechanism. J Am Chem Soc. 128(37):12331-8.

  8. Tan X. Loke HK, Fitch S, Lindahl PA. (2005) The tunnel of acetyl-coenzyme a synthase/carbon monoxide dehydrogenase regulates delivery of CO to the active site. J Am Chem Soc. 127(16):5833-9.

  9. Tan X. Bramlett MR, Lindahl PA. (2004) Effect of Zn on acetyl coenzyme a synthase: evidence for a conformational change in the alpha subunit during catalysis. J Am Chem Soc. 126(19):5954-5.

  10. Tan X. Sewell C, Yang Q, Lindahl PA. (2003) Reduction and methyl transfer kinetics of the alpha subunit from acetyl coenzyme a synthase. J Am Chem Soc. 125(2):318-9.

  11. Pan J, Zhang X, Yuan H, Xu Q, Zhang H, Zhou Y, Huang ZX, Tan X.* (2016) The molecular mechanism of heme loss from oxidized soluble guanylate cyclase induced by conformational change. Biochim Biophys Acta. 1864(5): 488-500.

  12. Zhao Y, Xu Q, Xu W, Wang D, Tan J, Zhu C, Tan X.* (2016) Probing the molecular mechanism of cerium oxide nanoparticles in protecting against the neuronal cytotoxicity of Aβ1-42 with copper ions. Metallomics. 8(7):644-7.

  13. Li W, Wang H, Chen Z, Ye Q, Tian Y, Xu X, Huang Z, Li P, Tan X* (2014) Probing the metal specificity mechanism of superoxide dismutase from human pathogen Clostridium difficile. ChemComm. 50(5):584-6.

  14. Xiaoping L, Zhong F, Tan X*. (2013) Cytochrome P450 2C8 and drug metabolism. Curr Top Med Chem. 13(18):2241-53.

  15. Zhu X, Li T, Gu X, Zhang S, Liu Y, Wang Y, Tan X*. (2013) Structural and functional investigation into acetyl-coenzyme A synthase and methyltransferase from human pathogen Clostridium difficile. Metallomics. 5(5): 551-8.

  16. Luo Y, Xu Y, Bao Q, Ding Z, Zhu C, Huang ZX, Tan X*. (2013) The molecular mechanism for human metallothionein-3 to protect against the neuronal cytotoxicity of Aβ (1-42) with Cu ions. J Biol Inorg Chem. 18(1):39-47.

  17. Wang H, Zhong F, Pan J, Li W, Su J, Huang ZX, Tan X*. (2012) Structural and functional insights into the heme-binding domain of the human soluble guanylate cyclase α2 subunit and heterodimeric α2β1. J Biol Inorg Chem. 17(5):719-30.

  18. Liu Y, Wang F, Li P, Tan X*. (2011) Insights into the mechanistic role of the [Fe4S4] cubane in the A-cluster {[Fe4S4]-(SR)-[NipNid]} of acetyl-coenzyme A synthase. ChemBioChem. 12(9):1417-21.

  19. Liu Y, Zhu X, Wang F, Ying T, Li P, Huang ZX, Tan X*. (2011) Probing the role of the bridging C509 between the [Fe4S4] cubane and the [Ni(p)Ni(d)] centre in the A-cluster of acetyl-coenzyme A synthase. ChemComm. 47(4):1291-3.

  20. Lei C, Rider SD Jr, Wang C, Zhang H, Tan X*, Zhu G* (2010) The apicomplexan Cryptosporidium parvum possesses a single mitochondrial-type ferredoxin and ferredoxin:NADP+ reductase system. Protein Sci. 19(11):2073-84.

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