课题组长
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  • 贺林

    博士,教授,博士生导师,中国科学院院士,发展中国家世界科学院院士
    地址:东安路131号,明道楼303室,上海 200032
    电话:021-54237615(办公室),021-54237620(实验室)
    传真:021-54237615
    邮箱:helinhelin3@163.com

工作经历
教授,复旦大学,生物医学研究院(2007.9-今)
教授,上海交通大学,Bio-X研究院(2000.1-今)
研究员,中国科学院上海生命科学研究院营养科学研究所(2003.1-今)
研究员,中科院上海生理研究所(1998.10-2003.1)
研究员,中科院上海生命科学中心脑研究所(1996.3-1998.9)
高年资研究员,英国MRC爱丁堡人类遗传学研究所(1992.12-1996.2)
博士后,英国爱丁堡大学(1991.1-1992.12)
教育经历
博士,英国西苏格兰大学,生物化学(1987-1991)
硕士,东南大学医学院,医学遗传学(1983-1986)
学士,东南大学医学院,基础医学(1978-1981)
所获人才项目
长江学者特聘教授,教育部,2002
国务院政府特殊津贴,国务院,1998
上海市政府津贴,上海市政府,1998
香港“求是”杰出青年,求是科技基金会,1998
国家杰出青年科学基金,国家自然科学基金,1997
所获奖项
上海市科学技术奖一等奖,上海市政府,2013
上海市科技功臣,上海市政府,2011
谈家桢生命科学成就奖,谈家桢生命科学奖评审委员会,2010
第三世界科学院生物奖,发展中国家世界科学院,2009
教育部对口支援工作先进个人,教育部,2009
国家自然科学奖二等奖,国务院,2003
上海市科学技术进步一等奖,上海市政府,2002
教育部科学技术(自然科学)一等奖,教育部,2002
“何梁何利” 奖,何梁何利基金评选委员会,2002
美国国家精神分裂症与抑郁症研究联盟(NARSAD)“杰出研究者”奖,美国国家精神分裂症与抑郁症研究联盟,2001
上海市科学技术进步三等奖,上海市科学技术奖励委员会,2001
上海市科技精英,上海市科学技术协会,2001
研究方向
单基因、多基因疾病(精神疾病),营养基因组学,药物基因组学,DNA计算等。
贺林院士担任首届世界转化医学学会主席,东亚人类遗传学联盟主席。两任国家973计划首席科学家,十五、十一五国家863计划主题和领域专家,数届国家自然科学基金委员会评委,国务院学位评定委员会成员, 中国遗传学会遗传咨询分会主任委员。多所大学、研究机构、重点实验室或重大项目的名誉教授、学术委员会主任或委员等职。目前被聘为Experimental Biology and Medicine副主编,Human Molecular Genetics,Cell Research, Psychiatric Genetics, Human Genetics等十多种科学杂志的编委。发表SCI论文400余篇,主编和参编专著17部,申请和已获授权专利20多项。
代表论文
  1. Yongyong Shi, Zhiqiang Li, Qi Xu, Ti Wang, Tao Li, Jiawei Shen, Fengyu Zhang, Jianhua Chen, Guoquan Zhou, Weidong Ji, Baojie Li, Yifeng Xu, Dengtang Liu, Peng Wang, Ping Yang, Benxiu Liu, Wensheng Sun, Chunling Wan, Shengying Qin, Guang He, Stacy Steinberg, Sven Cichon, Thomas Werge, Engilbert Sigurdsson, Sarah Tosato, Aarno Palotie, Markus M Nöthen, Marcella Rietschel, Roel A Ophoff, David A Collier, Dan Rujescu, David St Clair, Hreinn Stefansson, Kari Stefansson, Jue Ji, Qingzhong Wang, Wenjin Li, Linqing Zheng, Hairong Zhang, Guoyin Feng, Lin He*. Common variants on 8p12 and 1q24.2 confer risk of schizophrenia. Nature Genetics. 2011. 43(12):1224-7. (IF: 40.361, Nature Publishing Group Journal)

  2. Bo Gao, Jianxin Hu, Sigmar Stricker, Martin Cheung, Gang Ma, Kit Fong Law, Florian Witte, James Briscoe, Stefan Mundlos, Lin He*, Kathryn S.E. Cheah and Danny Chan*. A mutation in IHH that causes digit abnormalities alters its signalling capacity and range. Nature. 2009 Apr 30;458(7242):1196-200. (IF: 36.101, Nature Publishing Group Journal)

  3. Michael C O'Donovan, Nicholas Craddock, Nadine Norton, Hywel Williams, Timothy Peirce, Valentina Moskvina, Ivan Nikolov, Marian Hamshere, Liam Carroll, Lyudmila Georgieva, Sarah Dwyer, Peter Holmans, Jonathan L Marchini, Chris C A Spencer, Bryan Howie, Hin-Tak Leung, Annette M Hartmann, Hans-Jürgen Möller, Derek W Morris, YongYong Shi, GuoYin Feng, Per Hoffmann, Peter Propping, Catalina Vasilescu, Wolfgang Maier, Marcella Rietschel, Stanley Zammit, Johannes Schumacher, Emma M Quinn, Thomas G Schulze, Nigel M Williams, Ina Giegling, Nakao Iwata, Masashi Ikeda, Ariel Darvasi, Sagiv Shifman, Lin He, Jubao Duan, Alan R Sanders, Douglas F Levinson, Pablo V Gejman, Molecular Genetics of Schizophrenia Collaboration, Sven Cichon, Markus M Nöthen, Michael Gill, Aiden Corvin, Dan Rujescu, George Kirov & Michael J Owen. Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nature Genetics. 2008. 40 (9): 1053 -55 (IF: 40.361, Nature Publishing Group Journal)

  4. Li R, Fan W, Tian G, Zhu H, He L, Cai J, Huang Q, Cai Q, Li B, Bai Y, Zhang Z, Zhang Y, Wang W, Li J, Wei F, Li H, Jian M, Li J, Zhang Z, Nielsen R, Li D, Gu W, Yang Z, Xuan Z, Ryder OA, Leung FC, Zhou Y, Cao J, Sun X, Fu Y, Fang X, Guo X, Wang B, Hou R, Shen F, Mu B, Ni P, Lin R, Qian W, Wang G, Yu C, Nie W, Wang J, Wu Z, Liang H, Min J, Wu Q, Cheng S, Ruan J, Wang M, Shi Z, Wen M, Liu B, Ren X, Zheng H, Dong D, Cook K, Shan G, Zhang H, Kosiol C, Xie X, Lu Z, Zheng H, Li Y, Steiner CC, Lam TT, Lin S, Zhang Q, Li G, Tian J, Gong T, Liu H, Zhang D, Fang L, Ye C, Zhang J, Hu W, Xu A, Ren Y, Zhang G, Bruford MW, Li Q, Ma L, Guo Y, An N, Hu Y, Zheng Y, Shi Y, Li Z, Liu Q, Chen Y, Zhao J, Qu N, Zhao S, Tian F, Wang X, Wang H, Xu L, Liu X, Vinar T, Wang Y, Lam TW, Yiu SM, Liu S, Zhang H, Li D, Huang Y, Wang X, Yang G, Jiang Z, Wang J, Qin N, Li L, Li J, Bolund L, Kristiansen K, Wong GK, Olson M, Zhang X, Li S, Yang H, Wang J, Wang J. The sequence and de novo assembly of the giant panda genome. Nature. 2010. 463(7279):311-317. (IF: 36.101, Nature Publishing Group Journal) ( with equal contributions)

  5. David St Clair, Mingqing Xu, Peng Wang, Yaqin Yu, Yourong Fang, Feng Zhang, Xiaoying Zheng, Niufan Gu, Guoyin Feng, Pak Sham, Lin He*. Rates of adult schizophrenia following prenatal exposure to the Chinese famine of 1959-1961. JAMA. 2005. 294(5):557-62. (IF: 31.718)

  6. Peng Chen, Dun Pan, Chunhai Fan, Jianhua Chen, Ke Huang, Dongfang Wang, Honglu Zhang, You Li, Guoyin Feng, Peiji Liang, Lin He, Yongyong Shi. Gold nanoparticles for high-throughput genotyping of long-range haplotypes. Nature Nanotechnology. 2011. 6(10):639-44. (IF: 30.306)

  7. Junyan Li, Guoquan Zhou, Weidong Ji, Guoyin Feng, Qian Zhao, Jie Liu, Tao Li, You Li, Peng Chen, Zhen Zeng, Ti Wang, Zhiwei Hu, Linqing Zheng, Yang Wang, Yifeng Shen, Lin He, Yongyong Shi. Common Variants in the BCL9 Gene Conferring Risk of Schizophrenia. Archives of General Psychiatry. 2011. 68(3):232-40. (IF: 15.976)

  8. Zhen Zeng, Ti Wang, Tao Li, Y Li, Peng Chen, Qian Zhao, Jie Liu, J Li, Guoyin Feng, Lin He, Yongyong Shi. Common SNPs and haplotypes in DGKH are associated with bipolar disorder and schizophrenia in the Chinese Han population. Molecular Psychiatry. 2011. 16(5):473-5. (IF: 15.470, Nature Publishing Group Journal)

  9. M C O'Donovan, N Norton, H Williams, T Peirce, V Moskvina, I Nikolov, M Hamshere, L Carroll, L Georgieva, S Dwyer, P Holmans, J L Marchini, C C A Spencer, B Howie, H-T Leung, I Giegling, A M Hartmann, H-J Möller, D W Morris, Y Shi, G Feng, P Hoffmann, P Propping, C Vasilescu, W Maier, M Rietschel, S Zammit, J Schumacher, E M Quinn, T G Schulze, N Iwata, M Ikeda, A Darvasi, S Shifman, L He, J Duan, A R Sanders, D F Levinson, R Adolfsson, U Ösby, L Terenius, E G Jönsson, S Cichon, M M Nöthen, M Gill, A P Corvin, D Rujescu, P V Gejman, G Kirov, N Craddock, N M Williams and M J Owen Molecular Genetics of Schizophrenia Collaboration. Analysis of 10 independent samples provides evidence for association between schizophrenia and a SNP flanking fibroblast growth factor receptor 2. Molecular Psychiatry. 2009. 4(1):30-6. (IF: 15.470, Nature Publishing Group Journal)

  10. Bo Gao, Jingzhi Guo, Chaowen She, Anli Shu, Maosheng Yang, Zheng Tan, Xinping Yang, Shengzhen Guo, Guoying Feng, Lin He*. Mutations in IHH, encoding Indian hedgehog, cause brachydactyly type A-1. Nature Genetics, 2001; 8(4):386-8.(IF: 40.361, Nature Publishing Group Journal)

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