课题组长
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  • 杨芃原

    博士,教授,博士生导师
    地址:东安路 131号,明道楼 201室,上海 200032
    电话:021-65642009(办公室),021-54237961(实验室)
    传真:021-65642009
    邮箱:pyyang@fudan.edu.cn
    实验室主页:http://pyyangteam.fudan.edu.cn

工作经历
教授,常务副院长,复旦大学生物医学研究院(2005-今)
教授,期间任化学系副主任/主任,复旦大学化学系(2001-2006)
副教授,教授,厦门大学化学系(1991-1998)
教育经历
博士后,厦门大学化学系(1989-1991)
博士后,印第安纳大学化学系(1987-1989)
博士,美国麻州州立大学 化学系(1982-1987)
硕士,中国科学技术大学北京研究生院(1978-1981)
所获奖项
教育部自然科学奖(二等奖),教育部,2014
上海市自然科学奖(三等奖),上海市,2014
教育部自然科学奖(一等奖),教育部,2005
福建省科技进步奖(一等奖),福建省,2001
福建省科技进步奖(一等奖),福建省,2000
教育部科技进步奖(二等奖),教育部,1998
研究方向
疾病蛋白质组学、糖蛋白质组学、质谱仪器技术
代表论文
  1. Wang F, Wang K, Xu W, Zhao S, Ye D, Wang Y, Xu Y, Zhou L, Chu Y, Zhang C, Qin X, Yang PY*, and Yu H*. (2017) SIRT5 desuccinylates and activates pyruvate kinase M2 to block macrophage IL-1β production and to prevent DSS-induced colitis in mice. Cell Reports, 19: 2331–2344.

  2. Lin L, Ding Y, Wang Y, Wang Z, Yin X, Yan G, Zhang L, Yang P*, Shen H*. (2017) Functional lipidomics: palmitic acid impairs hepatocellular carcinoma development by modulating membrane fluidity and glucose metabolism. Hepatology, Accepted for publish

  3. Liu S, Xia Y, Liu X, Wang Y, Chen Z, Xie J, Qian J, Shen H*, Yang P*. (2017) In-depth proteomic profiling of left ventricular tissues in human end-stage dilated cardiomyopathy. Oncotarget

  4. Zeng WF, Liu MQ, Zhang Y, Wu JQ, Fang P, Peng C, Nie AY, Yan GQ, Cao WQ, Liu C, Chi H, Sun RX, Wong CC*, He SM*, Yang PY*. (2016) pGlyco: a pipeline for the identification of intact N-glycopeptides by using HCD-and CID-MS/MS and MS3. Scientific Reports, 6:25102.

  5. Gao X, Lin SH, Ren F, Li JT, Chen JJ, Yao CB, Yang HB, Jiang SX, Yan GQ, Wang D, Wang Y, Liu Y, Cai ZW, Xu YY, Chen J, Yu WQ, Yang PY*, Lei QY*. (2016) Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia. Nature Communications, 7:11960.

  6. Fang P, Wang XJ, Xue Y, Liu MQ, Zeng WF, Zhang Y, Zhang L, Gao X, Yan GQ, Yao J, Shen HL*, Yang PY*. (2016) In-depth mapping of the mouse brain N-glycoproteome reveals widespread N-glycosylation of diverse brain proteins. Oncotarget, 7, 38796-38809.

  7. Cao WQ, Huang JM, Jiang BY, Gao X, Yang PY. (2016) Highly Selective Enrichment of Glycopeptides Based on Zwitterionically Functionalized Soluble Nanopolymers. Scientific Reports, 6:29776.

  8. Liu MQ, Zhang Y, Chen YH, Yan GQ, Shen CP, Cao J, Zhou XW, Liu XH, Zhang L, Shen HL, Lu HJ, He FC, Yang PY*. (2014) Efficient and Accurate Glycopeptide Identification Pipeline for High-Throughput Site-Specific N-Glycosylation Analysis. J Proteome Research, 13, 3121-3129.

  9. Zhang W, Wang H, Tang H, Yang P*. (2011) Endoglycosidase-mediated incorporation of 18O into glycans for relative glycan quantitation. Anal Chem, 83, 4975-4981.

  10. Xu F, Wang YJ, Wang XD, Zhang YH, Tang Y*, Yang PY*. (2013) A Novel Hierarchical Nanozeolite Composite as Sorbent for Protein Separation in Immobilized Metal-Ion Affinity Chromatography. Adv Mater, 20(15):1751-1753.

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