课题组长
首页 > 人才队伍 > 课题组长
  • 李大强

    博士,研究员,博士生导师
    地址:东安路131号,上海 200032
    电话:021-34777589
    邮箱:daqiangli1974@fudan.edu.cn

工作经历
1998年7月及2003年7月在重庆医科大学分别获得医学学士学位及医学博士学位。2003年8月至2009年10月先后在复旦大学附属肿瘤医院、美国凯斯西储大学(Case Western Reserve University)、德州大学安德森肿瘤中心(University of Texas M.D. Anderson Cancer Center)及乔治华盛顿大学(George Washington University)从事博士后研究工作。
教育经历
2009年11月起任乔治华盛顿大学生物化学及分子生物学系Faculty 及Assistant Research Professor,并于2013年7月升职为Associate Research Professor。2013年8月底回国任复旦大学生物医学研究院及肿瘤研究所PI,入选2013年上海高校特聘教授 (东方学者) 。
研究方向
多年来一直致力于肿瘤侵袭转移及肿瘤治疗耐药分子机制的研究,在Cancer Cell, Mol Cell, Cell Rep, Nat Commun, PNAS, J Cell Biol及Hepatology等杂志上发表SCI论文30余篇,被Nature、Nat Rev Mol Cell Biol期刊及多家新闻媒体进行了新闻报道。现任Cancer Res, Transcriptomics: Open Access, JSM Biochem Mol Biol及AIMS Mol Sci杂志的编委(Editorial Board member)及十余种英文专业期刊的审稿人。
代表论文
  1. Li DQ*, Pakala SB*, Reddy SD, Peng S, Balasenthil1 S, Lee CC, Rea MA, Kumar R. Metastasis-associated protein 1 is an integral component of the circadian molecular machinery. Nat Commun, 2013; 4: 2545 (*Contributed equally)

  2. Li DQ*, Nair SS, Ohshiro K, Kumar A, Nair VS, Pakala SB, Reddy SD, Gajula RP, Eswaran J, Aravind L, Kumar R*. MORC2 signaling integrates phosphorylation-dependent, ATPase-coupled chromatin remodeling during the DNA damage response. Cell Rep, 2012; 2: 1657–1669 (*Co-corresponding authors)

  3. Li DQ, Pakala SB, Reddy SD, Ohshiro K, Zhang JX, Wang L, Zhang Y, de Alborán IM, Pillai MR, Eswaran J, Kumar R. Bidirectional autoregulatory mechanism of metastasis associated protein 1-alternative reading frame pathway in oncogenesis. Proc Natl Acad Sci U S A, 2011; 108: 8791-8796

  4. Li DQ, Ohshiro K, Reddy SD, Pakala SB, Lee MH, Zhang Y, Rayala SK, Kumar R. E3 ubiquitin ligase COP1 regulates the stability and functions of MTA1. Proc Natl Acad Sci U S A, 2009; 106: 17493-17498

  5. Zhang JX*, Li DQ*, He AR, Motwani M, Vasiliou V, Eswaran J, Mishra L, Kumar R. Synergistic inhibition of hepatocellular carcinoma growth by cotargeting chromatin modifying enzymes and poly (ADP-ribose) polymerases. Hepatology, 2012; 55: 1840-1851 (*Contributed equally)

  6. Molli PR*, Li DQ*, Bagheri-Yarmand R, Pakala SB, Katayama H, Sen S, Iyer J, Chernoff J, Tsai MY, Nair SS, Kumar R. Arpc1b, a centrosomal protein, is both an activator and substrate of Aurora A. J Cell Biol, 2010; 190: 101-114 (Comment in Nat Rev Mol Cell Biol, 2010; 11: 542) (*Contributed equally)

  7. Miao H, Li DQ, Mukherjee A, Guo H, Petty A, Cutter J, Basilion JP, Sedor J, Wu J, Danielpour D, Sloan AE, Cohen ML, Wang B. EphA2 mediates ligand-dependent inhibition and ligand-independent promotion of cell migration and invasion via a reciprocal regulatory loop with Akt. Cancer Cell, 2009; 16: 9-20 (Featured in Nature, 2009; 461:149 under Research Highlights)

  8. Nair SS, Li DQ, Kumar R. A core chromatin remodeling factor instructs global chromatin signaling through multivalent reading of nucleosome codes. Mol Cell, 2013; 49: 704–718

Top