课题组长
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  • 邢清和

    博士,研究员,博士生导师
    地址:东安路 131号,明道楼 303室,上海 200032
    电话:021-54237615(办公室),021-54237620(实验室)
    传真:021-54237615
    邮箱:xingqinghe@hotmail.com;qhxing@fudan.edu.cn

工作经历
研究员,复旦大学,生物医学研究院(2008.8-今)
副教授,上海交通大学,Bio-X研究院(2003.5-2008.7)
教育经历
博士,复旦大学,药学院(1997-2000)
硕士,河南医科大学,基础医学院(1991-1994)
研究方向
小儿脑瘫发生机制及分子诊断技术:小儿脑瘫位于儿童致残性疾病之首,拟通过基因组学、代谢组学和蛋白质组学等多组学研究其发病机制,寻找小儿脑瘫的致病基因,识别小儿脑瘫早期诊断或产前诊断分子标记,建立小儿脑瘫的新生儿筛查技术和产前诊断技术。
药物皮肤不良反应发生机制及个体化治疗技术:基于已经建立的严重皮肤不良反应的遗传资源库,通过药物基因组学研究识别相关基因,逐步建立相对完善的常见皮肤不良反应相关风险等位基因-致敏药物关联数据库,为临床实施个体化治疗、选择相对安全的药物提供分子标记和检测方法。
课题组长邢清和主持了多项国家和省部级项目,包括国家973计划、国家863计划、国家自然科学基金面上项目、国家自然科学基金国际合作项目、上海市科委项目等。迄今为止,以通讯或第一作者发表SCI论文65篇,包括Am J Hum Genet,Neuropsychopharmacology,Hepatology等。
代表论文
  1. Zhou D*, Kuang Z, Zeng X, Wang K, Ma J, Luo H, Chen M, Li Y, Zeng J, Li S, Luan F, He Y, Dai H, Liu B, Li H, He L, Xing Q* (2017) p53 regulates ERK1/2/CREB cascade via a novel SASH1/MAP2K2 crosstalk to induce hyperpigmentation. J Cell Mol Med. doi: 10.1111/jcmm.13168.

  2. Qiu YL, Gong JY, Feng JY, Wang RX, Han J, Liu T, Lu Y, Li LT, Zhang MH, Sheps JA, Wang NL, Yan YY, Li JQ, Chen L, Borchers CH, Sipos B, Knisely AS, Ling V*, Xing QH*, Wang JS* (2016) Defects in MYO5B are associated with a spectrum of previously undiagnosed low γ-glutamyltransferase cholestasis. Hepatology. doi: 10.1002/hep.29020.

  3. Yang Y, Chen S, Yang F, Zhang L, Alterovitz G, Zhu H, Xuan J, Yang X, Luo H, Mu J, He L, Luo X*, Xing Q* (2016) HLA-B*51:01 is strongly associated with clindamycin-related cutaneous adverse drug reactions. Pharmacogenomics J. 2016 Aug 16. doi: 10.1038/tpj.2016.61

  4. Yang F, Xuan J, Chen J, Zhong H, Luo H, Zhou P, Sun X, He L, Chen S, Cao Z, Luo X*, Xing Q* (2016) HLA-B*59:01: a marker for Stevens-Johnson syndrome/toxic epidermal necrolysis caused by methazolamide in Han Chinese. Pharmacogenomics J 16, 83-7

  5. Bi D, Chen M, Zhang X, Wang H, Xia L, Shang Q, Li T, Zhu D, Blomgren K, He L, Wang X, Xing Q*, Zhu C* (2014) The association between sex-related interleukin-6 gene polymorphisms and the risk for cerebral palsy. J Neuroinflammation 11, 100

  6. Wei Z, Jiang S, Zhang Y, Wang X, Peng X, Meng C, Liu Y, Wang H, Guo L, Qin S, He L, Shao F*, Zhang L*, Xing Q* (2014) The effect of microRNAs in the regulation of human CYP3A4: a systematic study using a mathematical model. Sci Rep 4, 4283

  7. Zhang JY, Chen XD, Zhang Z, Wang HL, Guo L, Liu Y, Zhao XZ, Cao W*, Xing QH*, Shao FM (2013) The adenosine deaminase acting on RNA 1 p150 isoform is involved in the pathogenesis of dyschromatosis symmetrica hereditaria. Br J Dermatol 169, 637-44

  8. Cao ZH, Wei ZY, Zhu QY, Zhang JY, Yang L, Qin SY, Shao LY, Zhang YT, Xuan JK, Li QL, Xu JH, Xu F, Ma L, Huang HY, Xing QH*, Luo XQ* (2012) HLA-B*58:01 allele is associated with augmented risk for both mild and severe cutaneous adverse reactions induced by allopurinol in Han Chinese. Pharmacogenomics 13(10), 1193-201

  9. Xuan J, Pan G, Qiu Y, Yang L, Su M, Liu Y, Chen J, Feng G, Fang Y, Jia W, Xing Q*, He L* (2011) Metabolomic profiling to identify potential serum biomarkers for schizophrenia and risperidone action. J Proteome Res 10, 5433-43

  10. Xuan J, Zhao X, He G, Yu L, Wang L, Tang W, Li X, Gu N, Feng G, Xing Q*, He L*(2008) Effects of the dopamine D3 receptor (DRD3) gene polymorphisms on risperidone response: a pharmacogenetic study. Neuropsychopharmacology 33, 305-11

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