课题组长
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  • 刘锋

    博士,研究员
    地址:东安路131号,明道楼415室,上海200032
    电话:021-54237451
    邮箱:jdiao@fudan.edu.cn

工作经历
2010/02-至今,复旦大学生物医学研究院,先后任副研/研究员
2015/02-至今,复旦大学附属闵行中心医院兼聘副教授、教授
1999/11-2010/01,国家人类基因组南方研究中心,先后任助研/副研/研究员
1999/08-1999/11,上海永业农科生物技术有限公司
1995/08-1996/08,安徽淮南抗生素药厂科研所
教育经历
2003/09-2006/07,复旦大学化学系,理学博士
1996/09-1999/07,浙江大学生物化学研究所,理学硕士
1991/09-1995/07,安徽大学生物系,理学学士
所获人才项目
2013,国家自然科学奖二等奖
2013,上海市自然科学奖一等奖
2011,上海市“青年科技启明星”跟踪人才计划
2010,第十一届中国青年科学奖
2009,明治乳业科学奖吃(杰出奖)
2008,上海市科教党委系统第二届青年科技创新人才奖
2007,上海市“青年科技启明星”人才计划
研究方向
前期从事功能基因组分泌蛋白基因、造血干细胞蛋白质组学研究,参与日本血吸虫大规模转录组(Nature Genetics 2003)、蛋白质组(PLoS Pathogens 2006)和基因组研究(Nature 2009),全面系统地绘制了血吸虫不同性别和生活周期基因表达谱,建成了世界最大的血吸虫功能基因组数据集,建立转录组和蛋白质整合数据库SjTPdb(BMC Genomics 2008),进行血吸虫与宿主相互作用蛋白质组学研究(Mol Cell Proteomics 2009、Proteomics 2007),为研究血吸虫生物学行为、致病机制、基因组结构和应用研究奠定基础。自2010年2月进入复旦大学生物医学研究院开始,研究方向转向肿瘤蛋白质组学与标志物、肿瘤微环境、肿瘤增殖/转移机制等研究。获得国家自然科学奖、上海市自然科学奖、中国青年科技奖等学术奖项。曾参与或承担863面上项目、973子课题、国家自然科学基金、十一五重大疾病专项、上海启明星项目及跟踪项目等科研项目。
代表论文
  1. Wang XQ#, Tang ZX#, Yu D#, Cui SJ, Jiang YH, Zhang Q, Wang J, Yang PY*, Liu F*. Epithelial but not stromal expression of collagen alpha-1(III) is a diagnostic and prognostic indicator of colorectal carcinoma. Oncotarget. 2016;7(8):8823-8838.

  2. Zhang Q#, Yan HB#, Wang J, Cui SJ, Wang XQ, Jiang YH, Feng L, Yang PY*, Liu F*. Chromatin remodeling gene AT-rich interactive domain-containing protein 1A suppresses gastric cancer cell proliferation by targeting PIK3CA and PDK1. Oncotarget. 2016;7(29):46127-46141.

  3. Qiao J#, Cui SJ#, Xu LL, Chen SJ, Yao J, Jiang YH, Peng G, Fang CY, Yang PY*, Liu F*. Filamin C, a dysregulated protein in cancer revealed by label-free quantitative proteomic analyses of human gastric cancer cells. Oncotarget. 2015;6(2):1171-1189.

  4. Zhang Q#, Wang XQ#, Wang J, Cui SJ, Lou XM, Yan B, Qiao J, Jiang YH, Zhang LJ, Yang PY, Liu F*. Upregulation of spondin-2 predicts poor survival of colorectal carcinoma patients. Oncotarget. 2015;6(17):15095-15110.

  5. Qiao J#, Fang CY#, Chen SX, Wang XQ, Cui SJ, Liu XH, Jiang YH, Wang J, Zhang Y, Yang PY, Liu F*. Stroma derived COL6A3 is a potential prognosis marker of colorectal carcinoma revealed by quantitative proteomics. Oncotarget. 2015;6(30):29929-29946.

  6. Qiao J#, Cui SJ#, Xu LL, Chen SJ, Yao J, Jiang YH, Peng G, Fang CY, Yang PY* and Liu F*. Filamin C, a dysregulated protein in cancer revealed by label-free quantitative proteomic analyses of human gastric cancer cells. Oncotarget. 2015, 6(2):1171-1189.

  7. Yan HB#, Wang XF#, Zhang Q#, Tang ZQ, Jiang YH, Fan HZ, Sun YH*, Yang PY and Liu F*. Reduced expression of the chromatin remodeling gene ARID1A enhances gastric cancer cell migration and invasion via downregulation of E-cadherin transcription. Carcinogenesis. 2014, 35(4):867-876.

  8. Chen SX#, Xu XE#, Wang XQ, Cui SJ, Xu LL, Jiang YH, Zhang Y, Yan HB, Zhang Q, Qiao J, Yang P-Y* and Liu F*. Identification of colonic fibroblast secretomes reveals secretory factors regulating colon cancer cell proliferation. J Proteomics. 2014, 110:155-171.

  9. Chen SX, Xu XE, Wang XQ, Cui SJ, Xu LL, Jiang YH, Zhang Y, Yan HB, Zhang Q, Qiao J, Yang PY and Liu F*. Data from a proteomic analysis of colonic fibroblasts secretomes. Data in Brief. 2014, 1:19-24.

  10. Cui SJ#, Xu LL#, Zhang T#, Xu M, Yao J, Fang CY, Feng Z, Yang PY*, Hu W* and Liu F*. Proteomic characterization of larval and adult developmental stages in Echinococcus granulosus reveals novel insight into host-parasite interactions. J Proteomics. 2013, 84:158-175.

  11. Schistosoma japonicum Genome S and Functional Analysis C. The Schistosoma japonicum genome reveals features of host-parasite interplay. Nature. 2009, 460(7253):345-351.
    Authorship:
    Genome annotation and evolution analysis: Yan Zhou#, Huajun Zheng#, Xiangyi Chen, Lei Zhang, Kai Wang, Jing Guo, Zhen Huang, Bo Zhang, Wei Huang, Ke Jin, Dou Tonghai, Masami Hasegawa, Li Wang, Yuan Zhang, Jie Zhou, Lin Tao, Zhiwei Cao, Yixue Li, Tomas Vinar, Brona Brejova, Dan Brown, Ming Li, David J. Miller, David Blair, Yang Zhong (Principal Investigator), Zhu Chen (Principal Investigator)
    Functional genomics analysis: Feng Liu#, Wei Hu#, Zhi-Qin Wang#, Qin-Hua Zhang, Huai-Dong Song, Saijuan Chen, Xuenian Xu, Bing Xu, Zhuan Ju, Yu Cheng, Paul J. Brindley, Donald P. McManus, Zheng Feng (Principal Investigator), Ze-Guang Han (Principal Investigator)
    Sequencing and assembly: Gang Lu#, Shuangxi Ren#, Yuezhu Wang, Wenyi Gu, Hui Kang, Jie Chen, Xiaoyun Chen, Shuting Chen, Lijun Wang, Jie Yan, Biyun Wang, Xinyan Lv, Lei Jin, Bofei Wang, Shiyin Pu, Xianglin Zhang, Wei Zhang, Qiuping Hu, Genfeng Zhu, Jun Wang, Jun Yu, Jian Wang, Huanmin Yang, Zemin Ning, Matthew Beriman, Chia-Lin Wei, Yijun Ruan, Guoping Zhao (Principal Investigator), Shengyue Wang (Principal Investigator)
    Paper writing: Feng Liu, Yan Zhou, Zhi-Qin Wang, Gang Lu, Huajun Zheng, Paul J. Brindley, Donald P. McManus, David Blair, Qinhua Zhang, Yang Zhong, Shengyue Wang, Ze-Guang Han, and Zhu Chen
    Project leaders: Shengyue Wang*, Ze-Guang Han*, Zhu Chen*

  12. Hu W#, Yan Q#, Shen DK#, Liu F#, Zhu ZD#, Song HD#, Xu XR#, Wang ZJ, Rong YP, Zeng LC, Wu J, Zhang X, Wang JJ, Xu XN, Wang SY, Fu G, Zhang XL, Wang ZQ, Brindley PJ, McManus DP, Xue CL, Feng Z#, Chen Z, Han ZG*. Evolutionary and biomedical implications of a Schistosoma japonicum complementary DNA resource. Nat Genet. 2003, 35(2):139-147.

  13. Liu F#, Cui SJ#, Hu W#, Feng Z, Wang ZQ and Han ZG*. Excretory/secretory proteome of the adult developmental stage of human blood fluke, Schistosoma japonicum. Mol Cell Proteomics. 2009, 8(6):1236-1251.

  14. Liu F*#, Chen P#, Cui SJ, Wang ZQ and Han ZG*. SjTPdb: integrated transcriptome and proteome database and analysis platform for Schistosoma japonicum. BMC Genomics. 2008, 9:304.

  15. Liu F#, Hu W#, Cui SJ, Chi M, Fang CY, Wang ZQ, Yang PY and Han ZG*. Insight into the host-parasite interplay by proteomic study of host proteins copurified with the human parasite, Schistosoma japonicum. Proteomics. 2007, 7(3):450-462.

  16. Liu F#, Lu J#, Hu W#, Wang SY, Cui SJ, Chi M, Yan Q, Wang XR, Song HD, Xu XN, Wang JJ, Zhang XL, Zhang X, Wang ZQ, Xue CL, Brindley PJ, McManus DP, Yang PY, Feng Z, Chen Z and Han ZG*. New perspectives on host-parasite interplay by comparative transcriptomic and proteomic analyses of Schistosoma japonicum. PLoS Pathog. 2006, 2(4):e29.

  17. Liu F#, Lu J#, Fan HH#, Wang ZQ#, Cui SJ, Zhang GA, Chi M, Zhang X, Yang PY, Chen Z and Han ZG*. Insights into human CD34+ hematopoietic stem/progenitor cells through a systematically proteomic survey coupled with transcriptome. Proteomics. 2006, 6(9):2673-2692.

  18. Yu J#, Liu F#, Cui SJ#, Liu Y, Song ZY, Cao H, Chen FE, Wang WJ, Sun T and Wang F*. Vitreous proteomic analysis of proliferative vitreoretinopathy. Proteomics. 2008, 8(17):3667-3678.

  19. Liu F, Rong YP, Zeng LC, Zhang X and Han ZG*. Isolation and characterization of a novel human thioredoxin-like gene hTLP19 encoding a secretory protein. Gene. 2003, 315:71-78.

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