课题组长
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  • 袁海心

    博士,青年研究员
    地址:东安路131号,明道楼803室,上海 200032
    电话:021-54237218
    传真:021-54237450
    邮箱:yuanhaixin@fudan.edu.cn
    实验室主页:http://mcb.fudan.edu.cn

工作经历
青年研究员,复旦大学,生物医学研究院(2014.11-至今)
博士后,美国加州大学圣迭戈分校(2009.09-2014.08)
教育经历
博士,中国科学院上海生化细胞所(2002-2009)
学士,中国科技大学生命科学学院(1998-2002)
研究方向
课题组主要从事细胞生长、增殖和代谢过程等基础和临床相关问题研究。运用生物化学、细胞生物学以及动物模型等实验手段,研究与肿瘤等疾病相关的信号转导通路、代谢酶的翻译后修饰(磷酸化、乙酰化和泛素化等)以及代谢酶突变等重要问题,期望揭示代谢异常与人类重大疾病尤其是肿瘤的关系,并寻找更有效的分子治疗手段。本人迄今共发表学术论文20余篇,其中第一作者和(共同)通讯作者论文发表于Nat Commun 、Gene Dev、Cancer Res、Oncogene、Autophagy和Hepatology等重要期刊,目前主持国家自然科学基金面上项目两项和国家科技重大专项一项(任务负责人)。
代表论文

1. Li FL, Liu JP, Bao RX, Yan G, Feng X, Xu YP, Sun YP, Yan W, Ling ZQ, Xiong Y, Guan KL and Yuan HX. Acetylation accumulates PFKFB3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis. Nat Commun 2018, 9:508.

2. Liu MX, Jin L, Sun SJ, Liu P, Feng X, Cheng ZL, Liu WR, Guan KL, Shi YH*, Yuan HX* and Xiong Y*. Metabolic reprogramming by PCK1 promotes TCA cataplerosis, oxidative stress and apoptosis in liver cancer cells and suppresses hepatocellular carcinoma. Oncogene 2018 DOI: 10.1038/s41388-017-0070-6. (*co-corresponding)

3. Mo Y, Lin R, Liu P, Tan M, Xiong Y, Guan KL, Yuan HX. SIRT7 deacetylates DDB1 and suppresses the activity of the CRL4 E3 ligase complexes. FEBS J. 2017 284: 3619-3636.

4. Wang Z, Liu P, Zhou X, Wang T, Feng X, Sun YP, Xiong Y*, Yuan HX*, Guan KL*. Endothelin promotes colorectal tumorigenesis by activating YAP/TAZ. Cancer Res. 2017, 77: 2413-2423. (*co-corresponding)

5. Feng X, Liu P, Zhou X, Li MT, Li FL, Wang Z, Meng ZP, Sun YP, Yu Y, Xiong Y*, Yuan HX*, and Guan KL*. Thromboxane A2 Activates YAP/TAZ to Induce Vascular Smooth Muscle Cell Proliferation and Migration. J Biol Chem. 2016, 291: 18947-18958. (*co-corresponding)

6. Yuan HX* and Guan KL*. Structural insights of mTOR complex 1. Cell Res. 2016, 26: 267-268. (*co-corresponding)

7. Yuan HX, Wang Z, Yu FX, Li F, Russell RC, Jewell JL, and Guan KL. NLK phosphorylates Raptor to mediate stress-induced mTORC1 inhibition. Gene Dev. 2015, 29: 2362-2376.

8. Yuan HX and Guan KL. The SIN1-PH Domain Connects mTORC2 to PI3K. Cancer Discov. 2015, 5: 1127-1129.

9. Yuan HX, Russell RC, and Guan KL. Regulation of PIK3C3/VPS34 complexes by MTOR in nutrient stress-induced autophagy. Autophagy 2013, 9: 1983-1995.

10. Russell RC, Yuan HX, and Guan KL. Autophagy regulation by nutrient signaling. Cell Res. 2014, 24: 42-57.

11. Yuan HX, Xiong Y, and Guan KL. Nutrient sensing, metabolism, and cell growth control. Mol Cell. 2013, 49: 379-387.

12. Yuan H#, Zhang H#, Wu X, Zhang Z, Du D, Zhou W, Zhou S, Brakebusch C, and Chen Z. Hepatocyte-specific deletion of Cdc42 results in delayed liver regeneration after partial hepatectomy in mice. Hepatology 2009, 49: 240-249. (#co-first)

 


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