课题组长
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  • 温文玉

    博士,研究员,博士生导师,复旦大学附属华山医院兼职教授

    地址:东安路131号,明道楼 915室,上海 200032

    电话:  021-54237501 (办公室),021-54237502 (实验室)

    邮件:  wywen@fudan.edu.cn

     



工作经历
研究员 复旦大学附属华山医院,神经外科,(2016.6-今)
研究员 复旦大学,生物医学研究院,(2012.12-今)
副研究员 复旦大学,生物医学研究院,(2009.1-2012.11)
博士后 香港科技大学,生物化学系(2008.2-2008.12)
教育经历
博士,香港科技大学,生物化学系(2003.9-2008.1)
学士,复旦大学,化学系(1999.9-2003.7)
所获人才项目
国家优秀青年科学基金,国家自然科学基金,2014
新世纪优秀人才,教育部,2012
青年拔尖人才,上海市委组织部,2016
曙光学者,上海市教委,2014
青年科技启明星,上海市科委,2010
研究方向
课题组综合结构生物学(核磁共振、X射线晶体衍射)、生物化学、细胞生物学及模式生物等多种手段,研究神经早期发育及神经信号转导过程中重要调控蛋白质的结构与功能,以及其与神经系统疾病(如脑肿瘤)的关联性。比较系统地研究了神经干细胞不对称分裂过程的分子机制,并修正了原有模型(Mol Cell, 2010;Mol Cell, 2011;EMBO J, 2011;JMB, 2013;Nat Commun, 2015;Structure, 2016;EMBO Rep, 2017;JBC, 2018;Nat Commun, 2018);提出了视觉支架蛋白INAD主动调节自身氧化还原电势进而介导信号传导过程的新机制(Cell, 2011, 封面文章)。
课题组长温文玉主持和参与多项国家及省部级项目,包括973课题、国家自然科学基金面上项目、上海市项目等。发表SCI论文20余篇,包括Cell, Molecular Cell, Nature Communications, EMBO J, EMBO Reports等。
代表论文

1. Shan, Z., Tu, Y., Yang, Y., Liu, Z., Zeng, M., Xu, H., Long, J., Zhang, M., Cai, Y.*, and Wen, W.* “Basal condensation of Numb and Pon complex via phase transition during Drosophila neuroblast asymmetric division” Nat. Commun. (2018) 9:737, doi: 10.1038/ s41467-018-03077-3.

2. Chen, X., Liu, Z., Shan, Z., Yao, W., Gu, A., and Wen, W.* “Structural determinants controlling 14-3-3 recruitment to the endocytic adaptor Numb and dissociation of the Numb/α-adaptin complex” J. Biol. Chem. (2018) doi:10.1074/jbc.RA117.000897.

3. Zhu, K., Shan, Z., Chen, X., Cai, Y., Cui, L., Yao, W., Wang, Z., Shi, P., Tian, C., Lou, J., Xie, Y., and Wen, W.* “Allosteric auto-inhibition and activation of the Nedd4 family E3 ligase Itch” EMBO Rep. (2017) 18, 1618-1630. 

4. Zhu, K., Shan, Z., Zhang, L., and Wen, W.* “Phospho-Pon binding mediated fine-tuning of Plk1 activity” Structure (2016) 24, 1110-1119.

5. Jia, M., Shan, Z., Yang, Y., Liu, C., Li, J., Luo, Z.-G., Zhang, M., Cai, Y.*, Wen, W.*, and Wang, W.* “The structural basis of Miranda-mediated Staufen localization during Drosophila neuroblast asymmetric division” Nat. Commun. (2015) 6:8381, doi: 10.1038/ncomms9381.

6. Pan, Z., Shang, Y., Jia, M., Zhang, L., Xia, C., Zhang, M., Wang, W.*, and Wen, W.* “Structural and biochemical characterization of the interaction between LGN and Frmpd1” J. Mol. Biol. (2013) 425, 1039-1049.

7. Zhu, J., Shang, Y., Xia, C., Wang, W., Wen, W.*, and Zhang, M.* “Guanylate Kinase Domains of the MAGUK Family Scaffold Proteins as Specific Phospho-protein-binding Modules” EMBO J. (2011) 30, 4986-4997.

8. Liu, W.#, Wen, W.#, Wei, Z., Yu, J., Ye, F., Liu, C.-H., Hardie, R.C., and Zhang, M. “The INAD scaffold is a dynamic, redox-regulated modulator of signaling in the Drosophila eye” Cell (2011) 145, 1088-1101. (#: co-first authors) (Cover article)

Highlights: F1000, http://f1000.com/prime/12082956

9. Zhu, J.#, Wen, W.#, Zheng, Z., Shang, Y., Wei, Z., Xiao, Z., Pan, Z., Du, Q., Wang, W., and Zhang, M. “LGN/mInsc and LGN/NuMA complex structures suggest distinct functions in asymmetric cell division for the Par3/mInsc/LGN and Gαi/LGN/NuMA pathways” Mol. Cell (2011) 43, 418-431. (#: co-first authors)  

10. Wen, W., Yu, J., Pan, L., Wei, Z., Weng, J., Wang, W., Ong, Y.S., Hoai, T.T.T., Hong, W., and Zhang, M. “Lipid-induced conformational switch controls fusion activity of longin domain SNARE Ykt6” Mol. Cell (2010) 37, 383-395.

Highlights: F1000, http://f1000.com/prime/2939958


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