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蛋白质组学前沿科学研讨会通知

发表时间:2010-09-09  |  阅读次数:27次  |  字体大小 [ ]

        随着人类基因组计划的实施和推进,生命科学研究进入了后基因组时代,蛋白质组学随之成为重大热点研究领域之一。在应用研究上,蛋白质组学是发现大量新型生物标志物、药靶和药物的重要途径,已成为生物医药产业及其相关产业发展的新生长点,此外,蛋白质组学对研究疾病不同阶段蛋白质的变化、诊断和防治等方面也具有广泛的应用价值。随着对蛋白质组学的深人研究,还将极大推进生物技术(基因工程、蛋白质工程、酶工程、细胞工程、发酵工程等)向更深、更广的方向发展,促进医学、药学及农业等很多领域的变革。蛋白质组学与其它大规模科学如基因组学,生物信息学等领域的交叉,所呈现出的系统生物学研究模式,也将成为未来生命科学最令人激动的新前沿。
        然而蛋白质组学尚处于发展阶段,蛋白质组学的兴起对技术有了新的需求和挑战。蛋白质组的研究实质上是在细胞水平上对蛋白质进行大规模的平行分离和分析,往往要同时处理成千上万种蛋白质。因此,发展高通量、高灵敏度、高准确性的研究技术平台对于蛋白质组学研究至关重要。
       质谱技术是目前蛋白质组研究中发展最快,也最具潜力的技术。对于蛋白质鉴定而言,高通量、高灵敏度和高精度是三个关键指标。一般的质谱技术难以将三者合一,而最近发展的质谱技术可以同时达到以上三个要求,从而实现对蛋白质准确和大规模的鉴定。
        针对上述情况,复旦大学生物医学研究院同安捷伦公司联合举办本次蛋白质组学前沿科学讨论会,并荣幸地邀请到了来自Scripps Research Institute的Catherine C.L. Wong博士,Catherine博士将从世界知名蛋白质组学实验室资深科学家的角度(Prof. John R. Yates III’s group),为我们详尽阐释蛋白质组学相关的研究前沿、应用热点、技术进展及发展趋势等广受关注的内容。其中您也可从用户的角度了解到安捷伦公司质谱系统在前沿蛋白质组学研究中的重要角色及突出贡献。
        本次研讨会将为您创造与世界知名蛋白质组学实验室资深科学家共同探讨、方便交流的机会,机会难得,诚邀您的参加与关注!

会议时间:2009年9月27日9:00

会议地点:东安路130号复旦大学明道楼二楼多功能会议厅


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Catherine C.L. Wong博士简介

SUMMARY OF QUALIFICATION
 Dr. Wong obtained her PhD degree in the University of Hong Kong with specific training in fundamental gas-phase mass spectrometry. 
 After graduate in 2003, she has been one of the project leaders in collaboration between Biopharmaceutical Development Center (BDC, HKU) and the Department of Health (HK S.A.R.) to establish a new standardization laboratory equipped with various advanced analytical instruments.
 She became a postdoctoral fellow in Prof John R Yates group at Scripps Research Institute since 2005. Now she is the current Staff Scientist in Scripps.
 Her expertise is at being able to well master various mass spectrometers and develop MS-based proteomic method, especially good at analysis of the labeled protein to determine the sites of modification and quantification.
 Dr. Wong is carrying out numerous collaborative projects and produced about 20 peer reviewed publications within 4 years, including high impact journals such as Science, Molecular Cell, PLoS Biology, etc.


PUBLICATIONS of 2010

1. A Cell Cycle Phosphoproteome of the Yeast Centrosome, J. M. Keck, M. H. Jones, C. C. Wong, J. Binkley, D. Chen, E. P. Holinger, M. Niepel, M. Rout, J. Vogel, A. Sidow, J. R. Yates III, and M. Winey, Science  2010 (under revewing).
2. An Oxidation-Induced Intramolecular Disulfide Bond Inactivates MKK6 by Inhibiting ATP Binding, Y. Diao, W. Liu, C. C. Wong, L. Pan, K. Lee, P. Cheung, J. R. III. Yates, J. Han, M. Zhang, and Z. Wu, PNAS 2010 (under revewing).
3. S-Nitrosylation of XIAP Regulates Caspase-Dependent Neuronal Cell Death, T. Nakamura, L. Wang, C. C. Wong, F. L. Scott, B. P. Eckelman, X. Han, C. Tzitzilonis, A. T. Clemente, S. Okamoto, G. S. Salvesen, R. Riek, J. R. III. Yates, and S. A. Lipton, Mol Cell  2010 (accepted, July).
4. Comparison of Different Signal Thresholds on Data Dependent Sampling in Orbitrap and LTQ mass spectrometry for the Identification of Peptides and Proteins in Complex  Mixtures, C. C. Wong, D. Cociorva, J. D. Venable, T. Xu, and J. R. Yates III, J Am Soc Mass Spectrom 2009, 20, 1405-14.
5. Identification of N-terminally arginylated proteins and peptides by mass spectrometry, T. Xu, C. C. Wong (co-first Author), A. Kashina, and J. R. Yates III, Nat Protoc 2009, 4, 325-32.
6. Global analysis of posttranslational protein arginylation, C. C. Wong, T. Xu, R. Rai, A. O. Bailey, J. R. Yates III, Y. I. Wolf, H. Zebroski, and A. Kashina, PLoS Biol 2007, 5, 2231-42.
7. Arginylation of beta-actin regulates actin cytoskeleton and cell motility, M. Karakozova, M. Kozak, C. C. Wong, A. O. Bailey, J. R. Yates III, A. Mogilner, H. Zebroski, and A. Kashina, Science 2006, 313, 192-6.

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